ALEXIS Biochemicals: Bestatin . hydrochloride

ALX-260-012

Revised 14-Aug-08

Bestatin . hydrochloride
SYNONYMS	[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Aminopeptidases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-012-M005		5 mg	55.00 USD
ALX-260-012-M025		25 mg	200.00 USD

Product Specification

FORMULA:	C₁₆H₂₄N₂O₄. HCl
MW:	308.4 . 36.5
CAS NUMBER:	65391-42-6
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol, acetic acid, DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions in organic solvents are stable for 1 month at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:	Protect from light.

Product Description

Inhibits aminopeptidases like aminopeptidase B, leucine aminopeptidase, tripeptide aminopeptidase, aminopeptidases on the surface of mammalian cells. Does not inhibit carboxypeptidases. May be used in in vitro translation system to inhibit the aminopeptidases found in reticulocate or wheat germ lysates. Activates macrophages and T lymphocytes. Has antitumor properties and enhances not only blastogenesis and lymphocytes in vitro, but also establishes a delayed-type hypersensitivity in vivo.

Product Specific Literature References

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes: H. Umezawa, et al.; J. Antibiot. 29, 97 (1976) Abstract
Low-molecular-weight enzyme inhibitors of microbial origin: H. Umezawa; Ann. Rev. Microbiol. 36, 75 (1982) Abstract
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem. 27, 417 (1984) Abstract

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Antitumor Agents (Enzyme Inhibitors)

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