ALEXIS Biochemicals: Bisindolylmaleimide I . hydrochloride

ALX-270-019

Revised 27-Apr-06

Bisindolylmaleimide I . hydrochloride
SYNONYMS	GF-109203X . HCl Gö 6850 . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKC Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-019-M001		1 mg	45.00 USD
ALX-270-019-M005		5 mg	150.00 USD

Product Specification

FORMULA:	C₂₅H₂₄N₄O₂ . HCl
MW:	412.5 . 36.5
PURITY:	≥98%
APPEARANCE:	Orange to red powder.
SOLUBILITY:	Soluble in DMSO or methanol. Slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Water soluble form of bisindolylmaleimide I (Prod. No. ALX-270-049), a protein kinase C (PKC) inhibitor.

Product Specific Literature References

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991) Abstract; Full Text
Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3- (dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5- dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model: S. Kuchera, et al.; Agents Actions 39, C169 (1993) Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet, et al.; J. Biol. Chem. 278, 4778 (2003) Abstract; Full Text

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