ALEXIS Biochemicals: Bisindolylmaleimide VIII . acetate

ALX-270-056

Revised 18-Jan-08

Bisindolylmaleimide VIII . acetate
SYNONYMS	Ro 31-7549 . acetate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKC Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-056-M001		1 mg	45.00 USD
ALX-270-056-M005		5 mg	150.00 USD

Product Specification

FORMULA:	C₂₄H₂₂N₄O₂ . CH₃COOH
MW:	398.5 . 60.1
CAS NUMBER:	138516-31-1
PURITY:	≥98%
APPEARANCE:	Red powder.
SOLUBILITY:	Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Product Specific Literature References

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999) Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002) Abstract; Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004) Abstract; Full Text

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