ALEXIS Biochemicals: Bistheonellide A

ALX-350-287

Revised 14-May-07

Bistheonellide A
SYNONYMS	Misakinolide A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cytoskeletal Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-287-C100		100 µg	470.00 USD

Product Specification

FORMULA:	C₇₄H₁₂₈O₂₀
MW:	1337.8
CAS NUMBER:	105304-96-9
SOURCE/HOST:	Isolated from the marine sponge Theonella sp.
PURITY:	≥95%
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Inhibits actin polymerization by forming a 1:2 complex with G-actin.

Product Specific Literature References

Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell. Struct. Func. 21, 199 (1996) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. (Tokyo) 123, 571 (1998) Abstract
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Meth. Enzymol. 298, 26 (1998) Abstract
A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide: F. Braet, et al.; PNAS 95, 13635 (1998) Abstract
Effects of Bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells: T. Oda, et al.; Mar. Drugs 4, 22 (2006)

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