ALEXIS Biochemicals: Boc-D(OMe)-FMK

ALX-260-071

Revised 14-Oct-05

Boc-D(OMe)-FMK
SYNONYMS	Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-071-M001		1 mg	210.00 USD
ALX-260-071-M005		5 mg	880.00 USD

Product Specification

SEQUENCE:	Boc-Asp(OMe)-fluoromethylketone
FORMULA:	C₁₁H₁₈FNO₅
MW:	263.3
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be divided into aliquots and stored at -20°C. For long term storage keep aliquots at -70°C.
HANDLING:	Keep cool and dry. After reconstitution, prepare aliquots and store at -80°C.

Product Description

Irreversible, cell permeable broad-spectrum caspase inhibitor.

Product Specific Literature References

Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996) Abstract
Caspase inhibitor BD-fmk distinguishes transforming growth factor β-induced apoptosis from growth inhibition: T.L. Brown, et al.; Cell Growth Differ. 9, 869 (1998) Abstract
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury: Y. Cheng, et al.; J. Clin. Invest. 101, 1992 (1998) Abstract; Full Text
A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation: S.R. D'Mello, et al.; J. Neurochem. 70, 1809 (1998) Abstract
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32: D. Vaudry, et. al.; PNAS 97, 13390 (2000) Abstract; Full Text

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