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CEACAM [CD66] / Related Products
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ALX-805-077 Revised 14-Sep-07
Monoclonal Antibody to CD66e (human) (26/3/13)
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SYNONYMS anti-CEACAM5 (human) MAb (26/3/13)
anti-CEA (human) MAb (26/3/13)
anti-Carcinoembryonic Antigen (human) MAb (26/3/13)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-077-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 26/3/13
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CD66e (CEACAM5; CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CD66e. Does not cross-react with human CEACAM1, 3, 4, 6, 7, 8 or PSG.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC cells transiently transfected with a CD66e expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
Effects of human bone marrow stroma on the growth of human tumor cells: E.S. Strobel, et al.; Cancer Res. 49, 1001 (1989) Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members: J. Thompson, et al.; Int. J. Cancer 55, 311 (1993) Abstract
CD66 family workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York and London 1012 (1996)
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
General Information
CD66e (CEACAM5; CEA) belongs to the carcinoembryonic antigen (CEA) gene family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 180'000-200'000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cells of the tongue, esophagus and cervix. CD66e is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-080 Revised 14-Sep-07
Monoclonal Antibody to pan-CEACAM (1,3,4,5,6) (human) (D14HD11)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-080-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: D14HD11
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CEACAM5 partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CEACAM1, 3, 4, 5 and 6.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Production and characterization of monoclonal antibodies against carcinoembryonic antigen (CEA): P. Jantscheff, et al.; Biomed. Biochim. Acta 50, 1261 (1991) Abstract
CD66 family Workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes: S.D. Gray-Owen, et al.; EMBO J. 16, 3435 (1997) Abstract; Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding: A. Popp, et al.; Cell. Microbiol. 1, 169 (1999) Abstract; Full Text
Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells J. Guignot, et al.; Infect. Immun. 68, 3554 (2000) Abstract; Full Text
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000) Abstract; Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells [...]: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001) Abstract; Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways: O. Billker, et al.; EMBO J. 21, 560 (2002) Abstract; Full Text
Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes: I.C. Boulton & S.D. Gray-Owen; Nat. Immunol. 3, 229 (2002) Abstract
The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression: D. Baczynska, et al.; Cell. Mol. Biol. Lett. 8, 471 (2003) Abstract; Full Text
General Information
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcionembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc. New York 459 (2002)
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-081 Revised 18-Aug-06
Monoclonal Antibody to pan-CEACAM (1,5,6,8) (human) (TET2)
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SYNONYMS anti-CD66a/CD66b/CD66c/CD66e (human) MAb (TET2)
anti-BGP/CEA/NCA/CGM5 (human) MAb (TET2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-081-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TET2
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN: CEACAM5 (CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY: Recognizes human CEACAM1, 5, 6 and 8.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot.
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM5 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns: F. Grunert, et al.; Int. J. Cancer 36, 357 (1985) Abstract
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York 1012 (1996)
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
General Information
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wiley Encylopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-076 Revised 05-May-08
Monoclonal Antibody to CEACAM1 (human) (GM8G5)
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SYNONYMS anti-CD66a (human) MAb (GM8G5)
anti-Biliary Glycoprotein 1 (human) MAb (GM8G5)
anti-BGP (human) MAb (GM8G5)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-076-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: GM8G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 2mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2. Contains no preservatives.
IMMUNOGEN: Vector containing the cDNA of human CEACAM1 A2 domain.
SPECIFICITY: Recognizes human CEACAM1. Does not cross-react with human CEACAM3, 4, 5, 6 or 8.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested on BOSC cells transiently transfected with a CEACAM1 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
Please click on thumbnails to enlarge.
General Information
CEACAM1 (CD66a, BGP) belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAMs.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-083 Revised 15-Oct-08
Monoclonal Antibody to CEACAM6 (human) (9A6)
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SYNONYMS anti-CD66c (human) MAb (9A6)
anti-NCA (human) MAb (9A6)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-083-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 9A6
ISOTYPE: Mouse IgG1
CONCENTRATION:  
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2. Contains no preservatives.
IMMUNOGEN: Tumor cell lines expressing human CEACAM6.
SPECIFICITY: Recognizes human CEACAM6. Does not cross-react with human CEACAM1, 3, 4, 5, 7 or 8.
APPLICATION: Flow Cytometry
ELISA
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC cells transiently transfected with a NCA expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Biochemical characterization and tissue distribution of the Cora antigen, a cell surface glycoprotein differentially expressed on malignant and benign gastrointestinal epithelia: H.G. Gottlinger, et al.; Cancer Res. 48, 2198 (1988) Abstract
Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants: S. Daniel, et al.; Int. J. Cancer 55, 303 (1993) Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members: J. Thompson, et al.; Int. J. Cancer 55, 311 (1993) Abstract
Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin: H. Hanenberg; Leukemia 12, 2127 (1994)
CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules: F. Grunert; Leukocyte Typing VI: White cell Differentiation Antigens (1996), Garland Publishing Inc., New York and London, pp. 1012
Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers: J. Wang, et al.; Mol. Microbiol. 30, 657 (1998) Abstract; Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999) Abstract
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000) Abstract; Full Text
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear facto: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001) Abstract; Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001) Abstract; Full Text
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells: P. Muenzner, et al.; J. Biol. Chem. 277, 7438 (2002) Abstract; Full Text
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes: B.B. Singer, et al.; J. Immunol. 168, 5139 (2002) Abstract; Full Text
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (2002), John Wiley & Sons Inc., New York, USA, pp. 459
Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens: T. Schmitter, et al.; J. Exp. Med. 199, 35 (2004) Abstract; Full Text
General Information
The normal cross-reacting antigen (NCA) or CEACAM6 belongs to the carcinoembryonic antigen (CEA) gene family. CEACAM6 is a GPI-anchored membrane protein with a single N domain, which shows structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like domains.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarstrom; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-079 Revised 10-Nov-04
Monoclonal Antibody to CEACAM7 (human) (BAC2)
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SYNONYMS anti-CGM2 (human) MAb (BAC2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY CEACAM [CD66] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-079-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: BAC2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS, pH 7.2,  containing 0.01% sodium azide.
IMMUNOGEN: Recombinant human CEACAM7.
SPECIFICITY: Recognizes human CEACAM7. Does not cross-react with human CEACAM1, 3, 4, 5, 6, 8 or PSG.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
QUALITY CONTROL: Routinely tested by flow cytometry on BOSC23 cells transiently transfected with a CEACAM7 expression vector.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding: A. Popp, et al.; Cell. Microbiol. 1, 169 (1999) Abstract; Full Text
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Schölzel, et al.; Am. J. Pathol. 156, 595 (2000) Abstract; Full Text
General Information
CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells of adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant-like A domain.
MANUFACTURER Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives: J.A. Thompson, et al.; J. Clin. Lab. Anal. 5, 344 (1991), (Review) Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues: S. Hammarström; Semin. Cancer Biol. 9, 67 (1999), (Review) Abstract
Carcinoembryonic antigen: W. Zimmermann; Wliey Enyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
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