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ALX-101-004 Revised 03-Aug-07
L-Arginine
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SYNONYMS H-L-Arg-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-004-G025   25 g 17.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O2
MW: 174.2
CAS NUMBER: 74-79-3
MERCK INDEX: 14: 780
RTECS: CF1934200
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Specific Literature References
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation: R.M.J. Palmer, et al.; BBRC 153, 1251 (1988) Abstract
Vascular endothelial cells synthesize nitric oxide from L-arginine: R.M.J. Palmer, et al.; Nature 333, 664 (1988) Abstract
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides: H.H.H.W. Schmidt, et al.; Science 255, 721 (1992) Abstract
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis: M. Joshi; Free Radic. Biol. Med. 22, 573 (1997), (Review) Abstract
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide: C. Didier, et al.; FASEB J. 13, 1817 (1999) Abstract; Full Text
L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways: M.B. Witte, et al.; Metabolism 51, 1269 (2002) Abstract
Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis: E.L. Heinzen & G.M. Pollack; Brain Res. 989, 67 (2003) Abstract
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide: P. Tsai, et al.; Biochem. Pharmacol. 69, 971 (2005) Abstract
Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide: S. Saleh & E. El-Demerdash; Basic Clin. Pharmacol. Toxicol. 97, 91 (2005) Abstract
General Information
Physiological precursor for the formation of nitric oxide (NO) by nitric oxide synthase (NOS). Enhances the release of NO.
Further Categories Containing This Product:
Arginine & Arginases / Related ProductsNitric Oxide Donors
 
 
ALX-101-005 Revised 22-Nov-06
D-Arginine
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SYNONYMS H-D-Arg-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-005-G005   5 g 62.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O2
MW: 174.2
CAS NUMBER: 157-06-2
PURITY: ≥99.0%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

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Arginine & Arginases / Related Products
 
 
ALX-101-036 Revised 22-Nov-06
L-Ornithine . hydrochloride
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-036-G005   5 g 12.00 USD Add To Cart
ALX-101-036-G025   25 g 27.00 USD Add To Cart
Product Specification
FORMULA: C5H12N2O2 . HCl
MW: 132.1 . 36.5
CAS NUMBER: 3184-13-2
MERCK INDEX: 14: 6874
RTECS: RM2985000
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Arginine & Arginases / Related Products
 
 
ALX-101-037 Revised 10-Feb-03
D-Ornithine . hydrochloride
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-037-G001   1 g 17.00 USD Add To Cart
ALX-101-037-G005   5 g 62.00 USD Add To Cart
Product Specification
FORMULA: C5H12N2O2 . HCl
MW: 132.1 . 36.5
CAS NUMBER: 16682-12-5
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

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Arginine & Arginases / Related Products
 
 
ALX-106-004 Revised 11-Jun-08
NG-Hydroxy-L-arginine . monoacetate
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SYNONYMS L-HOArg . AcOH
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-004-M005   5 mg 70.00 USD Add To Cart
ALX-106-004-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O3 . CH3COOH
MW: 190.2 . 60.1
CAS NUMBER: 53598-01-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Intermediate in the biosynthesis of nitric oxide from L-arginine by nitric oxide synthases (NOS). Inhibitor of arginases.
Product Specific Literature References
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate: M.A. Marletta, et al.; Biochemistry 27, 8706 (1988) Abstract
P.L. Feldman; THL 32, 875 (1991), [Synthesis]
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991) Abstract; Full Text
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine: G.C. Wallace & J.M. Fukuto; J. Med. Chem. 34, 1746 (1991), [Synthesis] Abstract
Nitric oxide and another potent vasodilator are formed from NG-hydroxy- L-arginine by cultured endothelial cells: A. Zembowicz, et al.; PNAS 88, 11172 (1991) Abstract
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery: G.C. Wallace, et al.; BBRC 176, 528 (1991) Abstract
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), [Synthesis] Abstract
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase: F. Daghigh, et al.; BBRC 202, 174 (1994) Abstract
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase: J.-L. Boucher, et al.; BBRC 203, 1614 (1994) Abstract
Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity: C.A. Schott, et al.; FEBS Lett. 341, 203 (1994) Abstract
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys. 315, 213 (1994) Abstract
Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis: M. Hecker, et al.; FEBS Lett. 359, 251 (1995) Abstract
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production: G.M. Buga, et al.; Am. J. Physiol. 271, H1988 (1996) Abstract
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms: G.M. Buga, et al.; Am. J. Physiol. 275, R1256 (1998) Abstract; Full Text
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Arginine & Arginases / Related Products
 
 
ALX-270-007 Revised 07-Jun-06
(2S)-(+)-Amino-5-iodoacetamidopentanoic acid
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SYNONYMS AIAP
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-007-M005   5 mg 42.00 USD Add To Cart
ALX-270-007-M025   25 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C7H13N2O3I
MW: 300.1
CAS NUMBER: 35748-65-3
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 6N aq. HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible inhibitor of arginase.
Product Specific Literature References
Uterine arginase inhibition affect the rat embryonic development: J.D. Méndez, et al.; Contraception 33, 597 (1986) Abstract
J.G. Trujillo, et al.; Synth. Commun. 21, 683 (1991)
Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase: C.A. Robertson, et al.; BBRC 197, 523 (1993) Abstract
Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages: A. Hrabák, et al.; BBRC 198, 206 (1994) Abstract
 
 
ALX-270-008 Revised 07-May-03
(2S)-(+)-Amino-6-iodoacetamidohexanoic acid
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SYNONYMS AIAH
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-008-M005   5 mg 42.00 USD Add To Cart
ALX-270-008-M025   25 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C8H15N2O3I
MW: 314.1
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 6N aq. HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible inhibitor of arginase.
Product Specific Literature References
Uterine arginase inhibition affect the rat embryonic development: J.D. Méndez, et al.; Contraception 33, 597 (1986) Abstract
J.G. Trujillo, et al.; Synth. Commun. 21, 683 (1991)
Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase: C.A. Robertson, et al.; BBRC 197, 523 (1993) Abstract
Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages: A. Hrabak, et al.; BBRC 198, 206 (1994) Abstract
 
 
ALX-270-283 Revised 06-May-08
DL-α-Difluoromethylornithine . hydrochloride . monohydrate
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SYNONYMS DFMO . HCl . H2O
Eflornithine . HCl . H2O
RMI-71782
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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ALX-270-283-M010   10 mg 25.00 USD Add To Cart
ALX-270-283-M050   50 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C6H12F2N2O2 . HCl . H2O
MW: 182.2 . 36.5 . 18.0
CAS NUMBER: 96020-91-6
MERCK INDEX: 14: 3522
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: HARMFUL.

Product Description
Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor.
Product Specific Literature References
Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice: N.J. Prakash, et al.; Cancer Res. 38, 3059 (1978) Abstract
Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase: S. Oredsson, et al.; Acta Chem. Scand. B 34, 457 (1980) Abstract
Kinetics of alpha-difluoromethylornithine: an irreversible inhibitor of ornithine decarboxylase: K.D. Haegele, et al.; Clin. Pharmacol. Ther. 30, 210 (1981) Abstract
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine: J.G. Delcros, et al.; FEBS Lett. 171, 221 (1984) Abstract
The effect of alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on mitogen-induced interleukin 2 production: T.L. Bowlin, et al.; Immunopharmacology 13, 143 (1987) Abstract
The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-alpha-difluoromethylornithine: a chemopreventive agent: A.K. Verma; Prev. Med. 18, 646 (1989) Abstract
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase: A.K. Verma; Basic Life Sci. 52, 195 (1990), (Review) Abstract
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity: M.A. Markwell, et al.; Eur. J. Pharmacol. 182, 607 (1990) Abstract
Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages?: D.M. Morgan; Biochem. Soc. Trans. 22, 389S (1994) Abstract
Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells: M. Selamnia, et al.; Biochem. Pharmacol. 55, 1241 (1998) Abstract
Development of difluoromethylornithine (DFMO) as a chemoprevention agent: F.L. Meyskens, Jr. & E.W. Gerner; Clin. Cancer Res. 5, 945 (1999), (Review) Abstract; Full Text
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model: Y. Takahashi, et al.; Int. J. Cancer 85, 243 (2000) Abstract
 
 
ALX-270-345 Revised 22-Sep-06
BEC . ammonium salt
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SYNONYMS S-(2-Boronoethyl)-L-cysteine . NH4
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-345-M001   1 mg 40.00 USD Add To Cart
ALX-270-345-M005   5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C5H11BNO4S . NH4
MW: 192.0 . 18.0
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry. Very hygroscopic. Keep under inert gas.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS: Identical to standard reference.

Product Description
Slow-binding competitive inhibitor of  arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) [1] and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase) [3]. Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue [1]. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation [4].
Product Specific Literature References
[1] Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum: N.N. Kim, et al.; Biochemistry 40, 2678 (2001) Abstract
[2] Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase: J.D. Cox, et al.; Biochemistry 40, 2689 (2001) Abstract
[3] Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori & D.E. Ash; Biochemistry 40, 9356 (2001) Abstract
[4] Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation: L.H. Wei, et al.; PNAS 98, 9260 (2001) Abstract; Full Text
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels: D.E. Berkowitz, et al.; Circulation 108, 2000 (2003) Abstract; Full Text
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005) Abstract; Full Text
Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium: A.S. Jung, et al.; Am. J. Physiol. Heart Circ. Physiol. 290, H1756 (2006) Abstract
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism: J. Steppan, et al.; PNAS 103, 4759 (2006) Abstract; Full Text
Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin: L.A. Holowatz, et al.; Am. J. Physiol. Heart Circ. Physiol. (in print) (2006) Abstract
 
 
ALX-270-420 Revised 11-Sep-07
ABH . ammonium salt
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SYNONYMS 2(S)-Amino-6-boronohexanoic acid . NH4
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
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ALX-270-420-M001   1 mg 60.00 USD Add To Cart
ALX-270-420-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C6H13BNO4 . NH4
MW: 174.0 . 18.0