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Bone Metabolism
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ALX-460-036 Revised 17-Jan-05
Alfacalcidol
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SYNONYMS Hydroxyvitamin D3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-036-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O2
MW: 400.6
CAS NUMBER: 41294-56-8
RTECS: VS2851000
PURITY: ≥97%
APPEARANCE: White to off white crystals.
SOLUBILITY: Soluble in ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No. ALX-460-032) in vivo. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
 
 
ALX-380-203 Revised 27-Jun-08
Ansatrienin A
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SYNONYMS Mycotrienin I
T 23I
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-203-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C36H48N2O8
MW: 636.8
CAS NUMBER: 82189-03-5
RTECS: AY4553220
SOURCE/HOST: Isolated from Streptomyces collinus.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antitumor antibiotic, closely related to the cytotrienins. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
 
 
ALX-380-204 Revised 17-Jun-08
Ansatrienin B
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SYNONYMS Mycotrienin II
T 23II
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-204-M001   1 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C36H50N2O8
MW: 638.8
CAS NUMBER: 82189-04-6
RTECS: AY4553430
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5998.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antitumor antibiotic, closely related to the cytotrienins. Displays potent anticancer activities. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
 
 
ALX-380-209 Revised 13-Nov-07
Bafilomycin C1
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SYNONYMS L-681,110A1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-209-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C39H60O12
MW: 720.4
CAS NUMBER: 88979-61-7
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5338.
PURITY: ≥95% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide oder DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Abstract
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Abstract
Further Categories Containing This Product:
H+-ATPase / Related Products • Antibiotics - Antifungal • Bone Metabolism Other Products
 
 
ALX-350-147 Revised 03-Oct-07
Bavachin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-147-MC05   0.5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 19879-32-4
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • Estrogen & Estrogen Receptors / Related Products • Flavanones • Bone Metabolism Other Products
 
 
ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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ALX-201-204/1-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~85.5kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100μg/ml after reconstitution.
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized from 0.1M K-HEPES, pH 7.0, containing 3% mannitol.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 100μl distilled water at +4°C for 30 minutes.
BIOLOGICAL ACTIVITY: Administration leads to ectopic bone formation in rats.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: The reconstituted solution can be diluted into other aqueous buffers and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor : F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-205/1 Revised 17-Jun-08 New product
Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS BMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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ALX-201-205/1-C010   10 µg 280.00 USD Add To Cart
Product Specification
MW: ~25.9kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100-500μg/ml after reconstitution. 
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 20-100μl 50mM sodium acetate solution, pH 4.3.
BIOLOGICAL ACTIVITY: Induces alkaline phosphatase expression at an EC50 = 14nM in C2C12 cells.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

The reconstituted solution can be further diluted in sodium acetate solution and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor: F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-019 Revised 16-Oct-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C16H24O4
MW: 280.4
CAS NUMBER: 20350-15-6
MERCK INDEX: 14: 1369
SOURCE/HOST: Isolated from Eupenicillium brefeldianum.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol, acetone or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specific Literature References
Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract
Further Categories Containing This Product:
ADP Ribosylation Factor [ARF] / Related Products • Golgi Apparatus • Collagen / Related Products • Na+ Channels • Antitumor Antibiotics • Antitumor Agents (Apoptosis Inducers) • Antibiotics - Antiviral / Anti-HIV • Antibiotics - Antifungal • Autophagy Other Products
 
 
ALX-153-021 Revised 26-Aug-02
Calcitonin (human)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Calcitonin & Calcitonin Receptors / Related Products
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ALX-153-021-MC05   0.5 mg 125.00 USD Add To Cart
ALX-153-021-M001   1 mg 220.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2
(Disulfide bond between Cys1-Cys7)
FORMULA: C151H226N40O45S3
MW: 3417.9
CAS NUMBER: 21215-62-3
MERCK INDEX: 14: 1643
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-001 Revised 26-Nov-04
Calcitonin (salmon)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Calcitonin & Calcitonin Receptors / Related Products
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ALX-153-001-MC05   0.5 mg 90.00 USD Add To Cart
ALX-153-001-M001   1 mg 140.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2
(Disulfide bond between Cys1-Cys7)
FORMULA: C145H240N44O48S2
MW: 3431.9
CAS NUMBER: 47931-85-1
MERCK INDEX: 14: 1643
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 0.05M acetic acid.
BIOLOGICAL ACTIVITY: ≥5000IU/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-460-032 Revised 18-Dec-07
Calcitriol
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SYNONYMS Vitamin D3, 1α,25-Dihydroxy-
1α,25-Dihydroxyvitamin D3
1,25(OH)2D3
1α,25-Dihydroxycholecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-032-C100   100 µg 150.00 USD Add To Cart
ALX-460-032-M001   1 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C27H44O3
MW: 416.7
CAS NUMBER: 32222-06-3
MERCK INDEX: 14: 1644
RTECS: FZ4645000
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Slightly soluble in methanol, 100% ethanol, ethyl acetate or tetrahydrofuran. 
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Osteotropic hormone that up-regulates RANKL level and down-regulates OPG level. Biologically active form of vitamin D3 in intestinal calcium transport and bone calcium resorption.
Product Specific Literature References
A rapidly acting metabolite of vitamin D3: Haussler, et al.; PNAS 68, 177 (1971) Abstract
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture: Raisz, et al.; Science 175, 768 (1972) Abstract
Further Categories Containing This Product:
Vitamins
 
 
ALX-201-239 Revised 12-Nov-08
Procathepsin K (human) (recombinant)
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SYNONYMS Procathepsin O (human) (recombinant)
Procathepsin O2 (human) (recombinant)
Procathepsin X (human) (recombinant