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Recombinant Proteins / Fusion Proteins
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ALX-201-288 Revised 05-Aug-08
ART2.2 (rat) (recombinant) (His)
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SYNONYMS ecto-ADP-ribosyltransferase 2 (rat) (recombinant) (His)
ART2b (rat) (recombinant) (His)
RT6.2 (rat) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
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ALX-201-288-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.31
SOURCE/HOST: Produced in E. coli. Rat ART2.2 is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of NAD, auto-ADP ribosylation
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat: H. Ritter, et al.; Biochemistry 42, 10155 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P20974: ART2b (rat)
General Literature References
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat: C. Mueller-Dieckmann, et al.; J. Mol. Biol. 322, 687 (2002) Abstract
Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2): C. Mueller-Dieckmann, et al.; Acta Crystallogr. D. Biol. Crystallogr. 58, 1211 (2002) Abstract
Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b: L.A. Stevens, et al.; J. Biol. Chem. 278, 19591 (2003) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose): A.R. Morrison, et al.; J. Biol. Chem. 281, 33363 (2006) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-522-025 Revised 25-Aug-08
BAFF, Soluble (human) (recombinant)
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SYNONYMS BlyS, Soluble (human) (recombinant)
TALL-1, Soluble (human) (recombinant)
THANK, Soluble (human) (recombinant)
zTNF4, Soluble (human) (recombinant)
TNFSF 13B/20, Soluble (human) (recombinant)
CD257, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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ALX-522-025-C010   10 µg 365.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human BAFF (aa 83-285) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human and mouse (weak) BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival. Induces monocyte survival.
APPLICATION: Detection of receptors of human soluble BAFF on target cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
BAFF mediates survival of peripheral immature B lymphocytes: M. Batten, et al.; J. Exp. Med. 192, 1453 (2000) Abstract; Full Text
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival: A.J. Novak, et al.; Blood 100, 2973 (2002) Abstract; Full Text
BAFF is a survival and maturation factor for mouse B cells: A.G. Rolink, et al.; Eur. J. Immunol. 32, 2004 (2002) Abstract
Expression of BLyS and its Receptors in B-Cell Non-Hodgkin Lymphoma: Correlation with Disease Activity and Patient Outcome: A.J. Novak, et al.; Blood 104, 2247 (2004) Abstract
TACI is mutant in common variable immunodeficiency and IgA deficiency: E. Castigli, et al.; Nat. Genet. 37, 829 (2005) Abstract
A role for BLyS in the activation of innate immune cells: S.K. Chang, et al.; Blood 108, 2687 (2006) Abstract; Full Text
Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF: W. Xu, et al.; J. Immunol. 181, 276 (2008) Abstract
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BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9Y275: BAFF (human)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production: L.G. Xu & H.B. Shu; J. Immunol. 169, 6883 (2002) Abstract; Full Text
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Recombinant Proteins / Fusion Proteins
 
 
ALX-522-052 Revised 02-May-07
BAFF, Soluble (mouse) (recombinant)
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SYNONYMS BLyS, Soluble (mouse) (recombinant)
TALL-1, Soluble (mouse) (recombinant)
THANK, Soluble (mouse) (recombinant)
zTNF4, Soluble (mouse) (recombinant)
TNFSF 13B/20, Soluble (mouse) (recombinant)
CD257, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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ALX-522-052-C010   10 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~17kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BAFF (aa 127-309) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
SPECIFICITY: Binds to human (weak) and mouse BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival: Y. Qian, et al.; Immunity 21, 575 (2004) Abstract
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway: A. Craxton, et al.; J. Exp. Med. 202, 1363 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9WU72: BAFF (mouse)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-060 Revised 31-May-05
BAFF-R (human):Fc (human) (recombinant)
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SYNONYMS BR3 (human):Fc (human) (recombinant)
BlySR3 (human):Fc (human) (recombinant)
TNFRSF 13C (human):Fc (human) (recombinant)
CD268 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF-R
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ALX-522-060-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~40kDa (SDS-PAGE)
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml (after reconstitution)
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse BAFF.
BIOLOGICAL ACTIVITY: Inhibits rhsBAFF mediated splenocyte survival.
APPLICATION: Detection of membrane-bound human and mouse BAFF in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BAFF-R:Fc is 10-fold more efficacious than BCMA:Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo. Thus BAFF-R:Fc becomes a promising therapeutic candidate as a BAFF-neutralizing compound in autoimmune disease intervention [1].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q96RJ3: BAFF-R (human)
AfCS Siganlling Gateway link A002648: BAFF-R (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF: M. Pelletier, et al.; J. Biol. Chem. 278, 33127 (2003) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-522-080 Revised 26-Aug-08
BAFF-R (mouse):Fc (human) (recombinant)
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SYNONYMS BR3 (mouse):Fc (human) (recombinant)
BlySR3 (mouse):Fc (human) (recombinant)
TNFRSF 13C (mouse):Fc (human) (recombinant)
CD268 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF-R
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ALX-522-080-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BAFF-R (aa 2-70) is fused at the C-terminus to a linker peptide (10 aa) and the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml (after reconstitution).
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse and human BAFF.
BIOLOGICAL ACTIVITY: Blocks the binding of mouse and human BAFF to their BAFF-receptors, inhibiting BAFF-mediated splenocyte survival.
APPLICATION: Flow Cytometry: Detection of membrane-bound mouse and human BAFF in combination with fluorescently labelled Ab to IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
General Information
BAFF-R:Fc is 10-fold more efficacious than BCMA:Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo. Thus BAFF-R:Fc becomes a promising therapeutic candidate as a BAFF-neutralizing compound in autoimmune disease intervention [1].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9D8D0: BAFF-R (mouse)
AfCS Siganlling Gateway link A002648: BAFF-R (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF: M. Pelletier, et al.; J. Biol. Chem. 278, 33127 (2003) Abstract
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16 467 2004 16, 467 (2004) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-026 Revised 26-Aug-08
BCMA (human):Fc (human) (recombinant)
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SYNONYMS B Cell Maturation Protein (human):Fc (human) (recombinant)
TNFRSF 17 (human):Fc (human) (recombinant)
CD269 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BCMA
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ALX-522-026-C050   50 µg 365.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~40kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl of sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse BAFF and APRIL.
BIOLOGICAL ACTIVITY: Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
APPLICATION: Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth: P. Rennert, et al.; J. Exp. Med. 192, 1677 (2000) Abstract; Full Text
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival: A.J. Novak, et al.; Blood 100, 2973 (2002) Abstract; Full Text
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q02223: BCMA (human)
AfCS Signalling Gateway link A000374: BCMA (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-079 Revised 26-Aug-08
BCMA (mouse):Fc (human) (recombinant)
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SYNONYMS B Cell Maturation Protein (mouse):Fc (human) (recombinant)
TNFRSF 17 (mouse):Fc (human) (recombinant)
CD269 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BCMA
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ALX-522-079-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BCMA (aa 1-46) is fused at the C-terminus to a linker peptide (2 aa) and the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse and human BAFF and human APRIL.
BIOLOGICAL ACTIVITY: Blocks the binding of mouse BAFF and human APRIL to their receptors BCMA and TACI, inhibiting BAFF and APRIL-mediated splenocyte survival.
APPLICATION: Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O88472: BCMA (mouse)
AfCS Signalling Gateway link A000374: BCMA (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-111 Revised 03-Mar-05
tBid (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
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ALX-201-111-C020   20 µg 230.00 USD Add To Cart