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Bone Metabolism
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ALX-210-343 Revised 25-Aug-05
Polyclonal Antibody to Osteoinductive Factor (human)
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SYNONYMS anti-OIF (human) PAb
anti-Osteoglycine (human) PAb
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Metabolism Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-343-R020   20 µl 161.00 USD Add To Cart
ALX-210-343-R100   100 µl 693.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with double distilled water.
IMMUNOGEN: Synthetic peptide corresponding to aa 108-122 (R108FNKIKKLTAKDFAD122) of human OIF (osteoinductive factor).
SPECIFICITY: Recognizes human OIF. Does not cross-react with human bone sialoprotein or osteopontin.
APPLICATION: ELISA (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-537 Revised 10-Apr-08
Polyclonal Antibody to CD51
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SYNONYMS anti-αV Integrin PAb
Polyclonal Antibody to Vitronectin Receptor (α Subunit)
anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-210-537-R100   100 µl 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
SOURCE/HOST: From rabbit.
PURITY: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY: Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION: ELISA
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
Immunoprecipitation (5µl per 5x106 cells)
Western Blot  (1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development: E. Hirsch, et al.; Dev. Dyn. 201, 108 (1994) Abstract
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products • Bone Metabolism Other Products • Adhesion Molecules & Receptors Antibodies • Polyclonal Antibodies
 
 
ALX-210-937 Revised 28-Apr-08
Polyclonal Antibody to RGMA (human) (AT115)
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SYNONYMS anti-Repulsive Guidance Molecule A (human) PAb (AT115)
anti-RGM Domain Family Member A (human) PAb (AT115)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Growth, Survival and Development of Neurons Other Products
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ALX-210-937-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMA (aa 48-422) (Prod. No. ALX-522-103).
SPECIFICITY: Recognizes human RGMA.
APPLICATION: Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Dependence Receptors Other Products • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-210-945 Revised 20-Jun-08
Polyclonal Antibody to Osteoprotegerin (human) (AT121)
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SYNONYMS anti-OPG (human) MAb (AT121)
anti-TNFRSF 11B (human) MAb (AT121)
anti-Osteoclastogenesis Inhibitory Factor (human) MAb (AT121)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-945-C100   100 µg 310.00 USD Add To Cart
ALX-210-945B-C100 Biotin 100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human osteoprotegerin (OPG) cysteine-rich region (aa 22-202) (Prod. No. ALX-522-007).
SPECIFICITY: Recognizes human OPG.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases: M. Baud’huin, et al.; Cell. Mol. Life Sci. 64, 2334 (2007) Abstract
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-396 Revised 27-Mar-08
Polyclonal Antibody to RANKL (human)
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SYNONYMS anti-ODF (human) PAb
anti-OPGL (human) PAb
anti-TRANCE (human) PAb
anti-TNFSF 11 (human) PAb
anti-CD254 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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ALX-210-396-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human RANKL.
SPECIFICITY: Recognizes human RANKL. Detects a band of ~35kDa band by Western blot.
APPLICATION: ELISA (direct and indirect: 1:2'000-1:10'000).
Flow Cytometry (1:500-1:1'000).
Western Blot (1:2'000-1:5'000 using ECL).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-421 Revised 30-Oct-06
Polyclonal Antibody to RANK (ectodomain) (human)
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SYNONYMS anti-TRANCE-R (ectodomain) (human) PAb
anti-ODFR (ectodomain) (human) PAb
anti-TNFRSF 11A (ectodomain) (human) PAb
anti-CD265 (ectodomain) (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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ALX-210-421-C050   50 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Contains no preservatives.
IMMUNOGEN: Recombinant human RANK.
SPECIFICITY: Recognizes human RANK. Detects a band of ~24kDa by Western blot.
APPLICATION: Flow Cytometry
Western blot (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-397 Revised 01-Apr-08
Polyclonal Antibody to Midkine (human)
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SYNONYMS anti-RIHB (human) PAb
anti-Neurite Outgrowth-promoting Factor 2 (human) PAb
anti-Amphiregulin-associated Protein (human) PAb
anti-ARAP (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
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ALX-210-397-C050   50 µg 399.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Affinity purified.
FORMULATION: Lyophilized from sterile filtered solution in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human midkine.
SPECIFICITY: Recognizes human midkine.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Midkine is a retinoic acid inducible heparin binding protein. Midkine promotes neuronal survival and neurite outgrowth and plays a role in carcinogenesis and tissue remodeling. Midkine expression is induced during remodeling after bone fractures.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-398 Revised 01-Jun-06
Polyclonal Antibody to Osteoblast Specific Factor 1 (human)
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SYNONYMS anti-OSF-1 (human) PAb
anti-Pleiotrophin (human)  PAb
anti-HB-GAM (human) PAb
anti-HARP (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
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ALX-210-398-C050   50 µg 430.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized from sterile filtered solution of affinity purified antibody in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OSF-1 (osteoblast specific factor 1).
SPECIFICITY: Recognizes human OSF-1.
APPLICATION: Immunohistochemistry
ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
OSF-1 is an extracellular matrix-associated protein, present in matrices, which act as targets for the deposition of new bone. OSF-1 has the ability to promote adhesion, migration, expansion and differentation of human osteoprogenitor cells.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-399 Revised 30-Sep-08
Polyclonal Antibody to Osteoblast Specific Factor 2
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SYNONYMS anti-OSF-2 PAb
anti-Periostin PAb
anti-Fasciclin-I-like PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
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ALX-210-399-C050   50 µg 430.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Affinity purified.
FORMULATION: Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride. Contains no preservatives.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OSF-2 (osteoblast specific factor 2).
SPECIFICITY: Recognizes human, mouse, rat and chicken OSF-2.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100-1:5'000))
Western Blot (0.1-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre: M.J. Blumer, et al.; J. Anat. 208, 695 (2006) Abstract
A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer: V. Castronovo, et al.; Mol. Cell. Proteomics 5, 2083 (2006) Abstract; Full Text
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data: A. Grigoriadis, et al.; Breast Cancer Res. 8, R56 (2006) Abstract; Full Text
Immunohistochemical localization of alpha-Smooth muscle actin during rat molar tooth development: A. Hosoya, et al.; J. Histochem. Cytochem. 54, 1371 (2006) Abstract
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma: X. Liang, et al.; J. Proteome Res. 5, 2632 (2006) Abstract
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells: P. Li, et al.; J. Appl. Physiol. 102, 390 (2007) Abstract
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity: M. Erkan, et al.; Gastroenterology 132, 1447 (2007) Abstract
General Information
OSF-2 functions as a cell-adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-308 Revised 17-Jul-07
Polyclonal Antibody to Osteocalcin (human) (NT)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-308-R020   20 µl 115.00 USD Add To Cart
ALX-210-308-R100   100 µl 486.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 20µl/100µl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-22 (Y1LYQWLGAPVPYP
DPLEPRREV22) of human mature osteocalcin.
SPECIFICITY: Recognizes human osteocalcin. Does not cross-react with human osteopontin, human osteonectin, human bone sialoprotein or bovine or sheep osteocalcin.
APPLICATION: ELISA (1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-333 Revised 24-Jul-08
Polyclonal Antibody to Osteocalcin (NT) (mouse)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products