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Bone Metabolism
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ALX-210-399 Revised 29-Jan-08
Polyclonal Antibody to Osteoblast Specific Factor 2
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SYNONYMS anti-OSF-2 PAb
anti-Periostin PAb
anti-Fasciclin-I-like PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
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ALX-210-399-C050   50 µg 430.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified and sterile filtered.
FORMULATION: Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 100µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OSF-2 (osteoblast specific factor 2).
SPECIFICITY: Recognizes human, rat and chicken OSF-2.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100-1:5'000))
Western Blot (0.1-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre: M.J. Blumer, et al.; J. Anat. 208, 695 (2006) Abstract
A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer: V. Castronovo, et al.; Mol. Cell. Proteomics 5, 2083 (2006) Abstract; Full Text
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data: A. Grigoriadis, et al.; Breast Cancer Res. 8, R56 (2006) Abstract; Full Text
Immunohistochemical localization of alpha-Smooth muscle actin during rat molar tooth development: A. Hosoya, et al.; J. Histochem. Cytochem. 54, 1371 (2006) Abstract
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma: X. Liang, et al.; J. Proteome Res. 5, 2632 (2006) Abstract
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells: P. Li, et al.; J. Appl. Physiol. 102, 390 (2007) Abstract
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity: M. Erkan, et al.; Gastroenterology 132, 1447 (2007) Abstract
General Information
OSF-2 functions as a cell-adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-421 Revised 30-Oct-06
Polyclonal Antibody to RANK (ectodomain) (human)
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SYNONYMS anti-TRANCE-R (ectodomain) (human) PAb
anti-ODFR (ectodomain) (human) PAb
anti-TNFRSF 11A (ectodomain) (human) PAb
anti-CD265 (ectodomain) (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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ALX-210-421-C050   50 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Contains no preservatives.
IMMUNOGEN: Recombinant human RANK.
SPECIFICITY: Recognizes human RANK. Detects a band of ~24kDa by Western blot.
APPLICATION: Flow Cytometry
Western blot (1:2'000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-537 Revised 10-Apr-08
Polyclonal Antibody to CD51
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SYNONYMS anti-αV Integrin PAb
Polyclonal Antibody to Vitronectin Receptor (α Subunit)
anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-210-537-R100   100 µl 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
SOURCE/HOST: From rabbit.
PURITY: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY: Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION: ELISA
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
Immunoprecipitation (5µl per 5x106 cells)
Western Blot  (1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development: E. Hirsch, et al.; Dev. Dyn. 201, 108 (1994) Abstract
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products • Polyclonal Antibodies • Bone Metabolism Other Products • Adhesion Molecules & Receptors Antibodies
 
 
ALX-210-937 Revised 28-Apr-08
Polyclonal Antibody to RGMA (human) (AT115)
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SYNONYMS anti-Repulsive Guidance Molecule A (human) PAb (AT115)
anti-RGM Domain Family Member A (human) PAb (AT115)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Growth, Survival and Development of Neurons Other Products
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ALX-210-937-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMA (aa 48-422) (Prod. No. ALX-522-103).
SPECIFICITY: Recognizes human RGMA.
APPLICATION: Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Dependence Receptors Other Products • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-210-945 Revised 20-Jun-08
Polyclonal Antibody to Osteoprotegerin (human) (AT121)
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SYNONYMS anti-OPG (human) MAb (AT121)
anti-TNFRSF 11B (human) MAb (AT121)
anti-Osteoclastogenesis Inhibitory Factor (human) MAb (AT121)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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ALX-210-945-C100   100 µg 310.00 USD Add To Cart
ALX-210-945B-C100 Biotin 100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human osteoprotegerin (OPG) cysteine-rich region (aa 22-202) (Prod. No. ALX-522-007).
SPECIFICITY: Recognizes human OPG.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases: M. Baud’huin, et al.; Cell. Mol. Life Sci. 64, 2334 (2007) Abstract
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-350-019 Revised 17-Apr-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C16H24O4
MW: 280.4
CAS NUMBER: 20350-15-6
MERCK INDEX: 14: 1369
SOURCE/HOST: Isolated from Eupenicillium brefeldianum.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methylene chloride or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specific Literature References
Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract
Further Categories Containing This Product:
Golgi Apparatus • ADP Ribosylation Factor [ARF] / Related Products • Autophagy Other Products • Collagen / Related Products • Na+ Channels • Antitumor Antibiotics • Antibiotics - Antifungal • Antitumor Agents (Apoptosis Inducers) • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-350-116 Revised 29-Nov-07
Sauchinone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-116-M001   1 mg 70.00 USD Add To Cart
ALX-350-116-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C20H20O6
MW: 356.4
SOURCE/HOST: Isolated from Saururus chinensis.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
Product Specific Literature References
Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000) Abstract
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000) Abstract
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003) Abstract
Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Bone Metabolism Other Products • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-350-147 Revised 03-Oct-07
Bavachin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-147-MC05   0.5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 19879-32-4
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract
Further Categories Containing This Product:
Estrogen & Estrogen Receptors / Related Products • Bone Metabolism Other Products • Flavonoids / Related Products • Natural Products - Immunomodulators
 
 
ALX-350-328 Revised 07-Apr-08
(+)-Madindoline A
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SYNONYMS MadA
MDL-A
[(2R), 3aR, 8aS]-8-[4-(n-Butyl)-2,5-dimethyl-1, 3-dioxo-2-(4-cyclopentyl)methyl]-3, 3a, 8,8a-tetrahydro-3a-hydroxy-2H-furo[2,3-b] indole
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin & Interleukin Receptors Other Products
Ordering Information
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ALX-350-328-MC05   0.5 mg 330.00 USD Add To Cart
ALX-350-328-M001   1 mg 580.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO4
MW: 370.2
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Light yellow needles
SOLUBILITY: Soluble in methanol or 100% ethanol; insoluble in hexane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Madindolines are noncytotoxic indole alkaloids originally isolated from a fermentation broth of Streptomyces nitrosporeus K93-071. (+)-Madindoline A (MadA; MDL-A) and (+)-madindoline B (MadB; MDL-B) are diastereomers with MadA being the more potent compound. MadA binds competitively but noncovalently to the extracellular domain of the membrane glycoprotein gp130 and inhibits the homodimerization of the trimeric IL-6/IL-6R/gp130 or the IL-11/gp130 complex, thus inhibiting activation of the JAK/STAT signal transduction pathway. MadA inhibits IL-6 and IL-11-induced osteoclastogenesis in vitro in a dose dependent manner and postmenopausal osteoporosis in vivo, by a mechanism different from that of 17β-estradiol. IL-6 activity is known to cause various diseases such as cancer cachexia, Castleman’s disease, Crohn’s disease, rheumatoid arthritis, hypercalcemia, and multiple myeloma. Madindolines are no longer available from natural sources due to mutation of the originating bacterial strain. Thus, synthetic routes have been developed to produce madindolines. Recently analogs of madindolines have been synthesized as potent IL-6 inhibitors.
Product Specific Literature References