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T Cell Signalling
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ALX-385-021 Revised 23-Oct-07
4'-Amino-6-hydroxyflavone
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SYNONYMS Aminogenistein
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-021-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H11NO3
MW: 253.3
PURITY: ≥95%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of the p56lck protein-tyrosine kinase.
Product Specific Literature References
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues: M. Cushman, et al.; J. Med. Chem. 34, 798 (1991) Abstract
Expression of p56lck in B-cell neoplasias: A. Von Knethen, et al.; Leuk. Lymphoma 26, 551 (1997) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related Products • Tyrosine Kinase Inhibitors • Kinases in T Cell Signal Transduction / Related Products
 
 
ALX-201-128 Revised 02-Jul-08
CD26 (human) (recombinant)
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SYNONYMS DPPIV (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD26 / Related Products
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ALX-201-128-1   1 Vial 257.00 USD Add To Cart
Product Specification
EC: 3.4.14.5
SOURCE/HOST: Produced in Sf9 cells.
QUANTITY: 5mU
CONCENTRATION: 40µg/ml (Pierce - BCA)
PURITY: ≥95% (SDS-PAGE, Western blot). No other protease contaminants detectable.
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 8.0, containing 5mM CaCl2, 1µM ZnCl2 and 0.05% sodium azide.
SPECIFIC ACTIVITY: ~10U/mg protein. One unit is defined as the amount of enzyme that produces 1µmol p-nitroaniline or 7-amino-4-methylcoumarin per min. at 37°C in 100mM TRIS-HCl, pH 8.5, using H-Gly-Pro-pNA or H-Gly-Pro-AMC as a substrate respectively (enzyme dilution >1:500; incubation time 10-30 min.).
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Inhibitors:
Very sensitive to diisopropyl fluorophosphate (DFP), less sensitive to other serine enzyme inhibitors such as phenylmethylsulfonyl fluoride (PMSF) (Prod. No. ALX-270-184) and diethyl 4-nitrophenylphosphate (E600). Most of the usual sulfhydryl reagents have little or no effect, nor do chelating agents.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-129 Revised 12-Apr-05
CD26 (rat) (recombinant)
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SYNONYMS DPPIV (rat) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD26 / Related Products
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ALX-201-129-1   1 Vial 303.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in Sf9 cells.
QUANTITY: 5mU
CONCENTRATION: 50µg/ml
PURITY: ≥95% (SDS-PAGE; Western blot)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 8.0, containing 5mM CaCl2, 1µM ZnCl2 and 0.05% sodium azide.
SPECIFIC ACTIVITY: One unit is defined as the amount of enzyme that produces 1µmol p-nitroaniline or 7-amino-4-methylcoumarin per min. at 37°C in 100mM TRIS-HCl, at pH 8.0, using H-Gly-Pro-pNA or H-Gly-Pro-AMC as a substrate respectively.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-027 Revised 24-Mar-05
CD30 (human):Fc (human) (recombinant)
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SYNONYMS Ki-1 (human):Fc (human) (recombinant)
TNFRSF 8 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD30 & CD30L / Related Products
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ALX-522-027-C050   50 µg 360.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~80kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human CD30 (Ki-1) (aa 1-380) is fused to the Fc portion of human IgG1 .
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human CD30L (CD153).
APPLICATION: Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD30L.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
The CD30 receptor (CD30, Ki-1) is a member of the tumor necrosis factor receptor (TNF-R) family. CD30 is a type I transmembrane receptor, it contains 6 extracellular cysteine-rich motifs, is shed by the TNFα-converting enzyme and is associated with the Reed-Sternberg cells of Hodgkins disease as well as with T cells and some lymphomas. Activated CD30 recruits TNF receptor-associated factor 1, 2, 3 and 5. CD30-CD30L have been reported to be involved in costimulation of T cell proliferation, induction of HIV expression, negative selection and apoptosis as well as in diabetes and several allergic, viral and autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss_prot link: CD30 (human) (precursor)
AfCS Signalling Gateway link: CD30 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-850-234 Revised 17-Apr-08
CD30, Soluble (human) ELISA Kit
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SYNONYMS Ki-1, Soluble (human) ELISA Kit
TNFSF 8, Soluble (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD30 & CD30L / Related Products
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ALX-850-234-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.33ng/ml (range 1.6 to 100ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human sCD30 in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
CD Kits & Sets • ELISA & EIA Kits
 
 
ALX-522-028 Revised 24-Mar-06
CD30L, Soluble (human) (recombinant)
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SYNONYMS CD153, Soluble (human) (recombinant)
TNFSF 8, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD30 & CD30L / Related Products
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ALX-522-028-C010   10 µg 200.00 USD Add To Cart
ALX-522-028-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of recombinant human CD30L (CD153) (aa 63-234) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human CD30 (Ki-1).
APPLICATION: Can be used together with an enhancer (Prod. No. 804-034, see Set Prod. No. 850-066) to detect membrane-bound human CD30. rhsCD30L saturates its receptor at a concentration range of 12-4000ng/ml.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Selective enrichment of CD30-expressing cells within the blast region of lymphocytes from patients with primary HIV infection (PHI): P. Biswas, et al.; J. Biol. Regul. Homeost. Agents 16, 33 (2002) Abstract
Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-kappaB Mutations or Activation of the CD30, CD40, and RANK Receptors: B. Zheng, et al.; Clin. Cancer Res. 10, 3207 (2004) Abstract
General Information
The CD30 ligand (CD30L, CD153) is a member of the tumor necrosis factor (TNF) family. CD30L is a type II, transmembrane protein expressed on T and B cells, monocytes/macrophages, neutrophils, megakaryocytes, erythroid precursors and eosinophils. After interaction with its receptor CD30, CD30L may induce TNF receptor-associated factor 1 (TRAF1), TRAF2, 3 and 5 recruitment. CD30-CD30L have been reported to be involved in costimulation of T cell proliferation, induction of HIV expression, negative selection and apoptosis as well as in diabetes and several allergic, viral and autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P32971: CD30L (human)
AfCS Signalling Gateway link A000555: CD30L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-850-066 Revised 23-Apr-08
CD30L, Soluble (human) (recombinant) Set
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SYNONYMS CD153, Soluble (human) (recombinant) Set
TNFSF 8, Soluble (human) (recombinant) Set
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD30 & CD30L / Related Products
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ALX-850-066-KI01   1 Set 460.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human CD30L (CD153) (aa 63-234) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
CONCENTRATION: CD30L: 0.1mg/ml after reconstitution.
Enhancer: 1mg/ml after reconstitution.
KIT/SET CONTAINS: 10µg of CD30L, Soluble (human) (recombinant) (Prod. No. ALX-522-028) and 2x50µg Enhancer for Ligands (Prod. No. ALX-804-034).
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Lyophilized. Contains PBS.
RECONSTITUTION: Reconstitute CD30L with 100µl and each vial of enhancer with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
SPECIFICITY: CD30L binds to human CD30 (Ki-1).
APPLICATION: Can be used together with anti-FLAG® MAb to detect membrane-bound human CD30. Co-stimulates T cells in the presence of cross-linking enhancer.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Selective enrichment of CD30-expressing cells within the blast region of lymphocytes from patients with primary HIV infection (PHI): P. Biswas, et al.; J. Biol. Regul. Homeost. Agents 16, 33 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Receptor / Ligand + Enhancer Set • CD Kits & Sets
 
 
ALX-522-094 Revised 27-Mar-08
CD30L, Soluble (mouse) (recombinant)
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SYNONYMS CD153, Soluble (mouse) (recombinant)
TNFSF8, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD30 & CD30L / Related Products
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ALX-522-094-C010   10 µg 365.00 USD Add To Cart
Product Specification
MW: ~42kDa (SDS-PAGE)
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD30L (CD153) (aa 71-239) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. The resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
SPECIFICITY: Binds to human and mouse CD30.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
The CD30 ligand is a member of the tumor necrosis factor (TNF) family. CD30L is a type II, transmembrane protein expressed on T and B cells, monocytes/macrophages, neutrophils, megakaryocytes, erythroid precursors and eosinophils. After interaction with its receptor CD30, CD30L may induce TNF receptor-associated factor 1 (TRAF1), TRAF2, 3 and 5 recruitment. CD30-CD30L have been reported to be involved in costimulation of T cell proliferation, induction of HIV expression, negative selection and apoptosis as well as in diabetes and several allergic, viral and autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P32972: CD30L (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression: M.Y. Kim, et al.; J. Immunol. 174, 6686 (2005) Abstract
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-022 Revised 29-Nov-05
CD134 (human):Fc (human) (recombinant)
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SYNONYMS TNFRSF 4 (human):Fc (human) (recombinant)
OX40 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
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ALX-522-022-C050   50 µg 368.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~72kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse CD134L (OX40L).
BIOLOGICAL ACTIVITY: Blocks T cell proliferation induced by CD134L.
APPLICATION: Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD134L. Has been used to ameliorate graft-versus-host disease, experimental allergic encephalomyelitis and inflammatory bowel disease.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes: E. Biagi, et al.; Blood 105, 2436 (2005) Abstract
General Information
The CD134 receptor (OX40) is a member of the tumor necrosis factor receptor (TNF-R) family. CD134 is a type I transmembrane receptor. It contains 3 extracellular cysteine-rich motifs. CD134 is mainly expressed in activated lymphocytes. After interaction with its ligand CD134L (OX40L), CD134 interacts with TNF receptor-associated factor 2 (TRAF2), TRAF5 and mediate activation of nuclear factors NF-κB and AP1. CD134-CD134L have been reported to be involved in T cell selection, migration and induction of Th1 and Th2 cytokine pattern. Moreover, it is involved in anti-tumor immunity, cell adhesion and various auto-immune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P43489: CD134 (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-023 Revised 20-Jun-06
CD134L, Soluble (human) (recombinant)
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SYNONYMS OX40L, Soluble (human) (recombinant)
TNFSF 4, Soluble (human) (recombinant)
CD252, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
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ALX-522-023-C010   10 µg 200.00 USD Add To Cart
ALX-522-023-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~30kDa (SDS-PAGE).