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Items 14 of 14
ALX-550-257
Revised 10-Feb-05
Amiloride, 5-(N-Methyl-N-isobutyl)-
SYNONYMS
5-(N-Methyl-N-isobutyl)amiloride
MIA
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Na+ Channels
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-257-M005
5 mg
25.00 USD
Product Specification
FORMULA:
C
11
H
18
ClN
7
O
MW:
299.8
CAS NUMBER:
96861-65-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dilute aqueous acid or DMSO; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Potent inhibitor of the Na
+
/H
+
antiporter. Possible antitumor agent.
Product Specific Literature References
Interactions of chloride and amiloride with the renal Na+/H/ antiporter:
D.G. Warnock, et al.; J. Biol. Chem.
263
, 7216 (1988)
Abstract
;
Full Text
Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters:
Z. Talor, et al.; Life Sci.
45
, 517 (1989)
Abstract
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy:
R.P. Maidorn, et al.; Br. J. Cancer.
67
, 297 (1993)
Abstract
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC:
I.Y. Novikova, et al.; Biochim. Biophys. Acta
1178
, 267 (1993)
Abstract
Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats
:
K.L. Lauro, et al.; Brain Res.
831
, 64 (1999)
Abstract
Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart
:
X.H. Xiao & D.G. Allen; Circ. Res.
85
, 723 (1999)
Abstract
Further Categories Containing This Product:
Imidazoline Binding Site Ligands
•
Ca2+ Channels (T-type)
•
Antitumor Reagents Other Products
ALX-400-041
Revised 11-Oct-05
Carboplatin
SYNONYMS
cis
-Diammine [1,1-cyclobutanedicarboxylato] platinum (II)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Antitumor Reagents Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-400-041-M025
25 mg
50.00 USD
ALX-400-041-M100
100 mg
175.00 USD
ALX-400-041-M250
250 mg
340.00 USD
Product Specification
FORMULA:
C
6
H
12
N
2
O
4
Pt
MW:
371.3
CAS NUMBER:
41575-94-4
MERCK INDEX:
14:
1822
PURITY:
≥98% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
An analog of cisplatin (Prod. No.
ALX-400-040
). Antitumor agent.
ALX-480-029
Revised 26-Sep-08
8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
SYNONYMS
8-Cl-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-029-M001
1 mg
27.00 USD
ALX-480-029-M005
5 mg
108.00 USD
Product Specification
FORMULA:
C
10
H
11
ClN
5
O
6
P . Na
MW:
363.7 . 23.0
CAS NUMBER:
41941-56-4
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water and aqueous buffers. May produce hazy solutions.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Specific Literature References
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth:
S. Ally, et al.; PNAS
85
, 6319 (1988)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-400-040
Revised 13-Aug-07
Cisplatin
SYNONYMS
cis
-Platinum(ll)diamine dichloride
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Antitumor Reagents Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-400-040-M050
50 mg
42.00 USD
ALX-400-040-M250
250 mg
90.00 USD
Product Specification
FORMULA:
Cl
2
H
6
N
2
Pt
MW:
300.0
CAS NUMBER:
15663-27-1
MERCK INDEX:
14:
2317
RTECS:
TP2450000
PURITY:
≥99% (Assay)
APPEARANCE:
Off-white to orange powder.
ENDOTOXIN CONTENT:
≤1.0EU/mg
SOLUBILITY:
Soluble in dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Specific Literature References
Cisplatin induces a persistent activation of JNK that is related to cell death:
I. Sanchez-Perez, et al.; Oncogene
16
, 533 (1998)
Abstract
Telomere loss in cells treated with cisplatin:
T. Ishibashi & S.J. Lippard; PNAS
95
, 4219 (1998)
Abstract
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin:
J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int.
47
, 765 (1999)
Abstract
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage:
J.G. Gong, et al.; Nature
399
, 806 (1999)
Abstract
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system:
M.S. Razzaque, et al.; Histochem. Cell Biol.
111
, 359 (1999)
Abstract
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma:
K. Seki, et al.; Cancer Chemother. Pharmacol.
45
, 199 (2000)
Abstract
Effectiveness of hsp90 inhibitors as anti-cancer drugs:
L. Xiao, et al.; Mini Rev. Med. Chem.
6
, 1137 (2006), (Review)
Abstract
Further Categories Containing This Product:
HSP90 / HtpG / Related Products
ALX-300-152
Revised 09-Feb-05
1-Elaidylphosphocholine (C18:1, trans)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-300-152-M250
250 mg
80.00 USD
ALX-300-152-G001
1 g
240.00 USD
Product Specification
FORMULA:
C
23
H
48
NO
4
P
MW:
433.6
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Cytotoxic alkylphosphocholine for a variey of tumor cells and protozoal diseases (leishmaniasis).
General Literature References
Hexadecylphosphocholine: a new and selective antitumor drug
:
H. Eibl & C. Unger; Cancer Treat. Rev.
17
, 233 (1990), (Review)
Abstract
Induction of tumor cell differentiation by alkylphosphocholines: a new approach for in vitro screening
:
H.R. Maurer & P. Hilgard; Prog. Exp. Tumor Res.
34
, 90 (1992), (Review)
Abstract
Alkylphosphocholines: a new class of membrane-active anticancer agents
:
P. Hilgard, et al.; Cancer Chemother. Pharmacol.
32
, 90 (1993), (Review)
Abstract
Current concepts of treatment in medical oncology: new anticancer drugs
:
C. Unger; J. Cancer Res. Clin. Oncol.
122
, 189 (1996), (Review)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-300-001
Revised 02-Dec-04
1-O-Hexadecyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamide . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-300-001-M005
5 mg
85.00 USD
ALX-300-001-M025
25 mg
335.00 USD
Product Specification
FORMULA:
C
53
H
105
NO
8
P . Na
MW:
915.4 . 23.0
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent antitumor agent.
Product Specific Literature References
Biologically active ether lipids. Biotransformation of rac-1(3)-O- alkylglycerols in cell suspension cultures of rape and semisynthesis of 1-O-alkyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamines, potent antitumor agents:
S.S. Apte, et al.; FEBS Lett.
265
, 104 (1990)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-270-361
Revised 28-Sep-07
Indirubin
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-361-M001
1 mg
50.00 USD
ALX-270-361-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
16
H
10
N
2
O
2
MW:
262.3
CAS NUMBER:
479-41-4
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (
1
H-NMR, HPLC)
APPEARANCE:
Purple powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or methanol (0.3mg/ml). Sparingly soluble in aqueous buffers (12.5µg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 2 years when stored at +4°C in the dark. Stock solutions should be stored in the dark and used within 1 month.
HANDLING:
Keep cool and dry. Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR, IR, ESI-MS and UV.
Product Description
Inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC
50
=10µM), CDK2/cyclin A (IC
50
=2.2µM), CDK2/cyclin E (IC
50
=7.5µM), CDK4/cyclin D1 (IC
50
=12µM), CDK5/p35 (IC
50
=5.5µM)) [1] and of GSK-3β (IC
50
=600nM) [2]. Inhibits inflammatory reaction in delayed-type hypersensitivity in mice [3]. Ligand of human aryl hydrocarbon receptor [4]. Exhibits anti-cancer activity [5] [6].
Product Specific Literature References
[1]
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
:
R. Hoessel, et al.; Nature Cell Biol.
1
, 60 (1999)
Abstract
[2]
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?:
S. Leclerc, et al.; J. Biol. Chem.
276
, 251 (2001)
Abstract
;
Full Text
[3]
Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity
:
T. Kunikata, et al.; Eur. J. Pharmacol.
410
, 93 (2000)
Abstract
[4]
Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine
:
J. Adachi, et al.; J. Biol. Chem.
276
, 31475 (2001)
Abstract
;
Full Text
[5]
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine:
G. Eisenbrand, et al.; J. Cancer Res. Clin. Oncol.
130
, 627 (2004)
Abstract
[6]
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway:
G. Sethi, et al.; J. Biol. Chem.
281
, 23425 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Indirubin is derived from various natural sources, such as
Indigofera indica, Isatis tinctoria
and
I. indigotica
by fermentation, oxidation and the presence of light as a by product of indigo formation. Indirubin is also present in human urine and fetal bovine serum [4]. Preclinical studies of indirubin its confirmed anti-tumor activity. Efficacy against chronic myelocytic leukemia was demonstrated in clinical trials in China [2].
Related Products
ALX-270-271
Indirubin-3'-monoxime
ALX-270-296
Indirubin-5-sulfonic acid . sodium salt
ALX-270-424
5-Iodo-indirubin-3'-monoxime
ALX-430-149
7BIO
ALX-430-157
Me-7BIO
ALX-430-156
6BIO
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products
•
GSK-3 Inhibitors
•
Antitumor Reagents Other Products
ALX-201-206
Revised 10-Feb-05
Melanoma Inhibitory Activity Protein (human) (recombinant)
SYNONYMS
MIA (human) (recombinant)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Antitumor Reagents Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-206-C020
20 µg
490.00 USD
Product Specification
MW:
~12.2kDa.
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 20mM potassium phosphate, pH 7.5, containing 150mM potassium chloride.
ENDOTOXIN CONTENT:
<0.05EU/µg protein.
BIOLOGICAL ACTIVITY:
Inhibits tumor growth
in vitro
.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
General Information
MANUFACTURER
Manufactured by Scil Proteins GmbH.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-300-094
Revised 18-Jul-07
Octadecyl-phosphocholine
SYNONYMS
C
18:0
-PC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-300-094-M250
250 mg
45.00 USD
ALX-300-094-G001
1 g
135.00 USD
Product Specification
FORMULA:
C
23
H
50
NO
4
P
MW:
435.6
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Potential antitumor agent.
Product Specific Literature References
H.R. Berger, et al.; Akt. Onkologie
34
, 27 (1987)
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-400-042
Revised 03-Mar-06
Oxaliplatin
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Antitumor Reagents Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-400-042-M005
5 mg
90.00 USD
ALX-400-042-M025
25 mg
340.00 USD
Product Specification
FORMULA:
C
8
H
14
N
2
O
4
Pt
MW:
397.3
CAS NUMBER:
61825-94-3
MERCK INDEX:
14:
6912
PURITY:
≥99% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Slightly soluble in water (7.9mg/ml). Very slightly soluble in methanol. Almost insoluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
A novel platinum analogue which has wide spectrum anticancer activity. It is found to be more active against human melanoma cell lines, and has better biochemical, pharmacological and cytotoxic properties than cisplatin and carboplatin.
ALX-430-097
Revised 29-Jan-05
2-Phthalimidino-glutaric acid
PRODUCT LINE
Cancer
