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Chemokines & Cytokines
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ALX-850-067 Revised 23-Apr-08
EDA-A1, Soluble (human) (recombinant) Set
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SYNONYMS Ectodysplasin-A1, Soluble (human) (recombinant) Set
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-067-KI01   1 Set 460.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. The extracellular domain of human ectodysplasin-A1 (EDA-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG®-tag.
CONCENTRATION: EDA-A1: 0.1mg/ml after reconstitution.
Enhancer: 1mg/ml after reconstitution.
KIT/SET CONTAINS: 10µg recombinant human soluble EDA-A1 (Prod. No. ALX-522-038) and 2x50µg Enhancer for Ligands (Prod. No. ALX-804-034).
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Lyophilized. Contains PBS.
RECONSTITUTION: Reconstitute EDA-A1 with 100µl sterile water and each vial of the enhancer with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
SPECIFICITY: EDA-A1 binds to human EDAR.
APPLICATION: For the assay use 0.2µg/ml EDA-A1 and 1µg/ml enhancer.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q92838: EDA-A1 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Receptor / Ligand + Enhancer Set • TNF-alpha & TNF Receptors Other Products
 
 
ALX-522-048 Revised 24-Oct-06
EDA-A2, Soluble (human) (recombinant)
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SYNONYMS Ectodysplasin-A2, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-048-C010   10 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human EDA-A2 (ectodysplasin-A2) (aa 245-391) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human XEDAR (X-linked ectodysplasin-A2 receptor).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-037 Revised 24-Oct-06
EDAR (human):Fc (human) (recombinant)
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SYNONYMS Anhidrotic Ectodysplasin-A1 Receptor (human):Fc (human) (recombinant)
EDA-A1 Receptor (human):Fc (human) (recombinant)
TNFRSF EDAR (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-037-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. The cysteine-rich region of human EDAR (ectodysplasin-A receptor) (aa 1-183) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human EDA-A1 (ectodysplasin-A1).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UNE0: EDAR (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-155-021 Revised 29-Jun-05
EGF Receptor (human) (651-658)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658)
EGFR (human) (651-658)
HER-1 (human) (651-658)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-021-M001   1 mg 50.00 USD Add To Cart
ALX-155-021-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C46H91N21O10
MW: 1098.4
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-155-022 Revised 29-Jun-05
EGF Receptor (human) (651-658) (N-Myristoylated)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658) (N-Myristoylated)
EGFR (human) (651-658) (N-Myristoylated)
HER-1 (human) (651-658) (N-Myristoylated)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-022-M001   1 mg 60.00 USD Add To Cart
ALX-155-022-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C60H117N21O11
MW: 1308.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent, cell permeable and possibly selective inhibitor of protein kinase C (PKC). This product is the N-terminal myristoylated form of Prod. No. ALX-155-021.
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Cyanobacteria secondary metabolites-the cyanotoxins: W.W. Carmichael; J. Appl. Bacteriol. 72, 445 (1992) Abstract
Inhibition of protein kinase C by N-myristoylated peptide substrate analogs: N.G. Ward & C.A. O'Brian; Biochemistry 32, 11903 (1993) Abstract
Further Categories Containing This Product:
Peptides • PKC Inhibitors
 
 
ALX-155-023 Revised 29-Jun-05
EGF Receptor (human) (652-657)
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SYNONYMS Epidermal Growth Factor Receptor (human) (652-657)
EGFR (human) (652-657)
HER-1 (human) (652-657)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-023-M001   1 mg 45.00 USD Add To Cart
ALX-155-023-M005   5 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Arg-Thr-Leu-Arg-Arg-OH
FORMULA: C34H68N16O8
MW: 829.0
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific substrate (aa 652-657 of mature EGF receptor, without signal peptide (aa 1-24)) for protein kinase C (PKC).
Product Specific Literature References
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells: L. Heasley & G.L. Johnson; J. Biol. Chem. 264, 8646 (1989) Abstract; Full Text
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-850-266 Revised 11-Apr-08
EGF Receptor, Soluble (active) (human) ELISA Kit
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-850-266-KI01   1 Kit 664.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.05fmol/ml (range 0.8 to 5fmol/ml)
QUANTITY: 96 wells (~80 tests)
APPLICATION: For the quantitative determination of soluble human epidermal growth factor receptor (hsEGF-R) in cell culture lysate, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-270-263 Revised 03-Apr-08
(-)-Epigallocatechin gallate
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SYNONYMS EGCG
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-263-M010   10 mg 20.00 USD Add To Cart
ALX-270-263-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H18O11
MW: 458.4
CAS NUMBER: 989-51-5
MERCK INDEX: 14: 3526
SOURCE/HOST: Isolated from green tea.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep under inert gas. Protect from light.

Product Description
Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.
Product Specific Literature References
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin: M.T. Huang, et al.; Carcinogenesis 13, 947 (1992) Abstract
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols: S.K. Katiyar, et al.; J. Invest. Dermatol. 105, 394 (1995) Abstract
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate: S. Liao, et al.; Cancer Lett. 96, 239 (1995) Abstract
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach: T. Yamane, et al.; Cancer Res. 55, 2081 (1995) Abstract
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine: E.S. Fiala, et al.; Experientia 52, 922 (1996) Abstract
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells: N. Ahmad, et al.; J. Natl. Cancer Inst. 89, 1881 (1997) Abstract
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea: M.M. Chan, et al.; Biochem. Pharmacol. 54, 1281 (1997) Abstract
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB: Y.L. Lin & J.K. Lin; Mol. Pharmacol. 52, 465 (1997) Abstract
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins: I. Naasani, et al.; BBRC 249, 391 (1998) Abstract
Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK: L.H. Lu, et al.; Br. J. Pharmacol. 124, 1227 (1998) Abstract
ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers: Q. Guo, et al.; Biochim. Biophys. Acta 1427, 13 (1999) Abstract
Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin: K. Dvorakova, et al.; Cancer Chemother. Pharmacol. 43, 331 (1999) Abstract
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin: S.K. Katiyar, et al.; Photochem. Photobiol. 69, 148 (1999) Abstract
Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals: S. Valcic, et al.; Chem. Res. Toxicol. 12, 382 (1999) Abstract
Antimutagenic and anticarcinogenic activity of tea polyphenols: Y. Kuroda & Y. Hara; Mutat. Res. 436, 69 (1999) Abstract
Inhibitory effect of green and black tea on tumor growth: A.H. Conney, et al.; Proc. Soc. Exp. Biol. Med. 220, 229 (1999) Abstract
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase: X. Wang & W. Tian; BBRC 288, 1200 (2001) Abstract
Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production: M.E. Waltner-Law, et al.; J. Biol. Chem. 277, 34933 (2002) Abstract; Full Text
The specificities of protein kinase inhibitors: an update:: J. Bain, et al.; Biochem. J. 371, 199 (2003) Abstract; Full Text
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters: M.N. Vankemmelbeke, et al.; Eur. J. Biochem. 270, 2394 (2003) Abstract
Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB: S.C. Ahn, et al.; BBRC 313, 148 (2004) Abstract
Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases: J.F. Sah, et al.; J. Biol. Chem. 279, 12755 (2004) Abstract
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004) Abstract
A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation: M. Lorenz, et al.; J. Biol. Chem. 279, 6190 (2004) Abstract; Full Text
Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants: J.H. Chen, et al.; Am. J. Clin. Nutr. 80, 742 (2004) Abstract; Full Text
Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: novel mechanisms of action: B.A. Sutherland, et al.; FASEB J. 19, 258 (2005) Abstract; Full Text
Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells: I.A. Persson, et al.; J. Pharm. Pharmacol. 58, 1139 (2006) Abstract
General Literature References
Anticarcinogenic effects of (-)-epigallocatechin gallate: H. Fujiki, et al.; Prev. Med. 21, 503 (1992), (Review) Abstract
Absorption, metabolism and antioxidative effects of tea catechin in humans: T. Miyazawa; Biofactors 13, 55 (2000), (Review) Abstract
Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea: Y.D. Jung and L.M. Ellis; Int. J. Exp. Pathol. 82, 309 (2001), (Review) Abstract
Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases: R. Benelli, et al.; Biol. Chem. 383, 101 (2002), (Review) Abstract
Further Categories Containing This Product:
Flavanols • NOS Inhibitors (NOS Induction & Enzyme Activity) • MAPK Pathway Inhibitors • Akt [PKB] / Related Products • EGFR Kinase Inhibitors • PKC Inhibitors • Telomerase / Related Products • Natural Products - Chemopreventive Agents • Fatty Acid Synthase [FAS] / Related Products • JNK [SAPK1] / Related Products • Active Substances from Fruit and Vegetables • Antitumor Agents (DNA Interaction & Gene Regulation) • Natural Products - Anti-inflammatory Agents • Natural Products for Angiogenesis Research • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Protein Kinase Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-201-419 Revised 14-Oct-08
Epstein-Barr Virus-induced Gene 3 (human):Fc (human) (recombinant)
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SYNONYMS EBI3 (human):Fc (human) (recombinant)
EBV-induced Gene 3 Protein (human):Fc (human) (recombinant)
IL-27 Subunit β (human):Fc (human) (recombinant)
Interleukin-27 Subunit β (human):Fc (human) (recombinant)
IL-27B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-419-C010   10 µg 280.00 USD Add To Cart
ALX-201-419-C050   50 µg 680.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Full-length human Epstein-Barr Virus-induced Gene 3 (aa 1-229) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q14213: Epstein-Barr Virus-induced Gene 3 (human) 
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin: O. Devergne, et al.; PNAS 94, 12041 (1997) Abstract; Full Text
IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells: W. Niedbala, et al.; Eur. J. Immunol. 37, 3021 (2007) Abstract; Full Text
The inhibitory cytokine IL-35 contributes to regulatory T-cell function: L.W. Collison, et al.; Nature 450, 566 (2007)