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T Cell Signalling
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ALX-522-055 Revised 24-Mar-05
DcR3 (human):Fc (human) (recombinant)
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SYNONYMS Decoy Receptor 3 (human):Fc (human) (recombinant)
TNFRSF 6B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT / LT-betaR / DcR3 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-055-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~58kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds human LIGHT. Does not bind human FasL.
APPLICATION: Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer: R.M. Pitti, et al.; Nature 396, 699 (1998) Abstract
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis: K.Y. Yu, et al.; J. Biol. Chem. 274, 13733 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O95407: DcR3 (human) (precursor)
AfCS Signalling Gateway link A000758: DcR3 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis: W. Roth, et al.; Cancer Res. 61, 2759 (2001) Abstract
Modulation of dendritic cell differentiation and maturation by decoy receptor 3: T.L. Hsu, et al.; J. Immunol. 168, 4846 (2002) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-370-002 Revised 19-Sep-06
Dexamethasone
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SYNONYMS 9α-Fluoro-16α-methylprednisolone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-002-M250   250 mg 22.00 USD Add To Cart
ALX-370-002-G001   1 g 45.00 USD Add To Cart
Product Specification
FORMULA: C22H29FO5
MW: 392.5
CAS NUMBER: 50-02-2
MERCK INDEX: 14: 2943
RTECS: TU3980000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?: S. Moncada & R.M.J. Palmer; TIPS 12, 130 (1991), (Review) Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells: K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta 1097, 227 (1991) Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells: C. Estrada, et al.; BBRC 186, 475 (1992) Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium: R.R. Dudek, et al.; BBRC 202, 1120 (1994) Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes: T. Grombacher, et al.; Carcinogenesis 17, 2329 (1996) Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone: T. Biswas, et al.; Oncogene 18, 525 (1999) Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases: M.G. Cifone, et al.; Blood 93, 2282 (1999) Abstract; Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2: M.S. Montani, et al.; Cell Death Differ 6, 79 (1999) Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation: T.D. Reil, et al.; J. Surg. Res. 92, 108 (2000) Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells: M. Matsumura, et al.; Life Sci. 69, 1067 (2001) Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages: R. Korhonen, et al.; Mol. Pharmacol. 62, 698 (2002) Abstract; Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells: J. Shinoda, et al.; Glia 42, 68 (2003) Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line: A.L. Vital, et al.; Mediators Inflamm. 12, 71 (2003) Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles: S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol. 288, H436 (2005) Abstract; Full Text
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Further Categories Containing This Product:
GITR & GITRL Other Products • RANK & RANKL / OPG Other Products • Antitumor Agents (Hormone-related) • DNA & RNA Methyl & Alkyl Transferases / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Chemopreventive Agents Other Products • Cell Cycle Other Products
 
 
ALX-385-031 Revised 07-Oct-08
Diosmin
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SYNONYMS 3’,5,7-Trihydroxy-4’-methoxyflavone 7-rutinoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-031-G005   5 g 30.00 USD Add To Cart
ALX-385-031-G025   25 g 90.00 USD Add To Cart
Product Specification
FORMULA: C28H32O15
MW: 608.5
CAS NUMBER: 520-27-4
MERCK INDEX: 14: 3297
SOURCE/HOST: Isolated from Citrus aurantium L. and Citrus reticulate Blanca.
PURITY: ≥90% (HPLC)
APPEARANCE: Light yellow to brown yellow powder.
SOLUBILITY: Soluble in DMSO (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
IDENTITY: Determined by IR.

Product Description

Flavonoid glycoside. Reduces venous hyperpressure. Reduces capillary hyperpermeability and the expression of endothelial adhesion molecules (ICAM1, VCAM1). Effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells. Anti-inflammatory.
Product Specific Literature References
Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids: W. Thanapongsathorn & T. Vajrabukka; Dis. Colon Rectum 35, 1085 (1992) Abstract
Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines: E. Sher, et al.; Pharmacol. Res. 26, 395 (1992) Abstract
Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils: B. Cypriani, et al.; Biochem. Pharmacol. 45, 1531 (1993) Abstract
Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein: J.P. Savineau & R. Marthan; Br. J. Pharmacol. 111, 978 (1994) Abstract; Full Text
Venous elasticity after treatment with Daflon 500 mg: V. Ibegbuna, et al.; Angiology 48, 45 (1997) Abstract
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice: M. Yang, et al.; Int. J. Cancer 73, 719 (1997) Abstract
Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity: H.P. Ciolino, et al.; Cancer Res. 58, 2754 (1998) Abstract; Full Text
Modulation by phytochemicals of cytochrome P450-linked enzyme activity: R.W. Teel & H. Huynh; Cancer Lett. 133, 135 (1998) Abstract
Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin: M.F. Melzig & R. Loose; Pharmazie 54, 298 (1999) Abstract
Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS: M.E. Crespo, et al.; Planta Med. 65, 651 (1999) Abstract
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells: Q. Zheng, et al.; J. Cancer Res. Clin. Oncol. 128, 539 (2002) Abstract
The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury: M. Pehlivan, et al.; Acta Chir. Belg. 104, 715 (2004) Abstract
Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin: C. Martinez Conesa, et al.; J. Agric. Food Chem. 53, 6791 (2005) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Natural Products - Chemopreventive Agents • Natural Products - Anti-inflammatory Agents • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • MDR Other Products
 
 
ALX-350-057 Revised 20-Feb-08
Emodin
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SYNONYMS 6-Methyl-1,3,8-trihydroxyanthraquinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-057-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 518-82-1
MERCK INDEX: 14: 3561
RTECS: CB7920600
SOURCE/HOST: Isolated from Frangula bark.
PURITY: ≥96% (HPLC)
APPEARANCE: Orange to red solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or 1N dilute aqueous ammonia; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of p56lck tyrosine kinase. Has mutagenic and genotoxic effects, mainly in bacterial systems. Anticancer agent. Exhibits anti-proliferative effects in various cancer cell lines by efficient induction of apoptosis. Has inhibitory effects on angiogenic and metastasis regulatory processes. Anti-inflammatory compound. Suppresses NF-κB activation. 
Product Specific Literature References
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum: H. Jayasuriya, et al.; J. Nat. Prod. 55, 696 (1992) Abstract
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor: T.C.K. Chan, et al.; BBRC 193, 1152 (1993) Abstract
Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent: G. Srinivas, et al.; Med. Res. Rev. 27, 591 (2007), (Review) Abstract
Further Categories Containing This Product:
Kinases in T Cell Signal Transduction / Related Products • Tyrosine Kinase Inhibitors • Src Family Kinases / Related Products • Other Toxins • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Antitumor Reagents
 
 
ALX-270-466 Revised 14-Sep-07
Fluvastatin . sodium salt
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-466-M010   10 mg 48.00 USD Add To Cart
ALX-270-466-M050   50 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C24H25FNO4 . Na
MW: 410.5 . 23.0
CAS NUMBER: 93957-54-1
MERCK INDEX: 14: 4218
RTECS: MJ9675050
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE TERATOGENIC.

Product Description
Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.
Product Specific Literature References
Folate and carcinogenesis: an integrated scheme: S.W. Choi and J.B. Mason; J. Nutr. 130, 129 (2000) Abstract; Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart: T. Obata, et al.; Biochim. Biophys. Acta 1536, 55 (2001) Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes: A. Yamamoto, et al.; J. Pharm. Pharmacol. 53, 227 (2001) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-302-010 Revised 28-Aug-07
Ganglioside GD3 . disodium salt (bovine brain)
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SYNONYMS Disialoganglioside GD3 . 2Na (bovine brain)
GD3 . 2Na (bovine brain)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Gangliosides / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-302-010-MC05   0.5 mg 150.00 USD Add To Cart
ALX-302-010-M001   1 mg 260.00 USD Add To Cart
Product Specification
SEQUENCE: [Il3(Neu5Ac)2LacCer] [[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer]
FORMULA: C70H123N3O29 . 2Na
MW: 1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
CAS NUMBER: 62010-37-1
PURITY: ≥98% (TLC)
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis.
Product Specific Literature References
Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition: B.S. Kristal & A.M. Brown; J. Biol. Chem. 274, 23169 (1999) Abstract; Full Text
Lipid signaling in CD95-mediated apoptosis: F. Malisan & R. Testi; FEBS Lett 452, 100 (1999), (Review) Abstract
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis: B.S. Kristal & A.M. Brown; Ann. NY Acad. Sci. 893, 321 (1999), (Review) Abstract
Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria: Y. Inoki, et al.; BBRC 276, 1210 (2000) Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • Natural Killer T [NKT] Cells / Related Products
 
 
ALX-522-061 Revised 31-Aug-06
GITR (human):Fc (human) (recombinant)
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SYNONYMS Glucocorticoid-induced TNFR-related Protein (human):Fc (human) (recombinant)
AITR (human):Fc (human) (recombinant)
Activation-inducible TNFR Family Receptor (human):Fc (human) (recombinant)
TNFRSF 18 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-061-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~47kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human GITR (AITR) (aa 26-161) is fused to the Fc portion of human IgG1.
QUANTITY: 50µg
CONCENTRATION: 1mg/ml.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human GITRL (AITRL).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5U5: GITR (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-024 Revised 31-Aug-06
GITR (mouse):Fc (human) (recombinant)
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SYNONYMS Glucocorticoid-induced TNFR-related Protein (mouse):Fc (human) (recombinant)
TNFRSF 18 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-024-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~45kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse GITRL.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice: H. H. Shin, et al.; Exp. Mol. Med. 35, 358 (2003) Abstract; Full Text
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells: M. Tone, et al.; PNAS 100, 15059 (2003) Abstract
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation: S. Cuzzocrea, et al.; J. Immunol. 177, 631 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O35714: GITR (mouse) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
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