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ALX-340-060
Revised 10-Jul-08
Arachidonoyl serotonin
SYNONYMS
AA-5HT
N-[2-(5-Hydroxy-1
H
-indol-3-yl)]ethyl-5Z,8Z,11Z,14Z-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-060-M005
5 mg
55.00 USD
Product Specification
FORMULA:
C
30
H
42
N
2
O
2
MW:
462.7
CAS NUMBER:
187947-37-1
PURITY:
≥98%
FORMULATION:
Liquid. Solution in methyl acetate.
SOLUBILITY:
Soluble in 100% ethanol (15mg/ml), DMSO (30mg/ml), dimethyl formamide (30mg/ml) or PBS, pH 7.2 (290μg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Tight binding, competitive inhibitor of fatty acid amide hydrolase (FAAH) (IC
50
=12µM).
Product Specific Literature References
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase
:
T. Bisogno, et al.; BBRC
248
, 515 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-340-001
Revised 28-Jul-06
Arachidonyl trifluoromethylketone
SYNONYMS
AACOCF
3
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-001-M005
5 mg
70.00 USD
ALX-340-001-M010
10 mg
110.00 USD
ALX-340-001-M050
50 mg
390.00 USD
Product Specification
FORMULA:
C
21
H
31
F
3
O
MW:
356.5
CAS NUMBER:
149301-79-1
PURITY:
≥98%
APPEARANCE:
Clear to yellow oil.
SOLUBILITY:
25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container. Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C.
HANDLING:
PROTECT FROM AIR!
HAZARD:
TOXIC.
Product Description
Selective inhibitor of both, Ca
2+-
dependent and Ca
2+
-independent phospholipase A
2
(PLA
2
), but not secretory PLA
2
(sPLA
2
). Also inhibits fatty acid amide hydrolase (FAAH) and anandamide amidase.
Product Specific Literature References
Inhibitors of arachidonoyl ethanolamide hydrolysis:
B. Koutek, et al.; J. Biol. Chem.
269
, 22937 (1994)
Abstract
;
Full Text
Further Categories Containing This Product:
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-260-136
Revised 16-Jun-05
H-Arg-Lys-Leu-Leu-Trp-NH2
SYNONYMS
RKLLW-NH
2
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-136-M001
1 mg
30.00 USD
ALX-260-136-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
35
H
59
N
11
O
5
MW:
713.9
PURITY:
≥98%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly potent peptide inhibitor of human cathepsin L.
Product Specific Literature References
Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections::
A. Brinker, et al.; Eur. J. Biochem.
267
, 5085 (2000)
Abstract
ALX-340-042
Revised 07-Jan-06
Arvanil
SYNONYMS
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5
Z
,8
Z
,11
Z
,14
Z
-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Agonists & Antagonists / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-042-M005
5 mg
25.00 USD
Product Specification
FORMULA:
C
28
H
41
NO
3
MW:
439.6
CAS NUMBER:
128007-31-8
PURITY:
≥98%
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep cool and dry.
Product Description
"Hybrid" activator of CB
1
receptor (CB
1
: K
i
=0.5µM; CB
2
: K
i
=>15µM) and TRPV1 (K
i
=0.3µM). Also inhibits anandamide uptake (IC
50
=3.6µM) and fatty acid amide hydrolase (FAAH) (IC
50
=3µM). Analgesic, vasodilatory and anti-inflammatory
in vivo
. Apoptosis inducer.
Product Specific Literature References
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors:
D. Melck, et al.; BBRC
262
, 275 (1999)
Abstract
Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide
:
V. Di Marzo, et al.; Eur. J. Pharmacol.
406
, 363 (2000)
Abstract
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid
:
V. Di Marzo, et al.; J. Pharmacol. Exp. Ther.
300
, 984 (2002)
Abstract
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway
:
R. Sancho, et al.; Br. J. Pharmacol.
140
, 1035 (2003)
Abstract
Evidence against the presence of an anandamide transporter
:
S.T. Glaser, et al.; PNAS
100
, 4269 (2003)
Abstract
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease:
E. de Lago, et al.; Brain Res.
1050
, 210 (2005)
Abstract
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis:
A.M. Malfitano, et al.; J. Neuroimmunol.
171
, 110 (2006)
Abstract
Further Categories Containing This Product:
Anandamide Uptake Inhibitors
•
TRPV1 Agonists and Antagonists / Related Products
•
Apoptosis Inducers & Inhibitors Other Products
•
Anti-inflammatory Agents Other Products
•
Analgesic / Anti-nociceptive Agents / Related Products
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-270-465
Revised 22-May-07
AS-252424
SYNONYMS
5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-465-M001
1 mg
30.00 USD
ALX-270-465-M005
5 mg
120.00 USD
ALX-270-465-M025
25 mg
480.00 USD
Product Specification
FORMULA:
C
14
H
8
FNO
4
S
MW:
305.3
CAS NUMBER:
900515-16-4
PURITY:
≥98% (
1
H-NMR)
APPEARANCE:
Yellow to brown crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receip when stored at -20°C.
Product Description
Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.
Product Specific Literature References
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils:
A.M. Condliffe, et al.; Blood
106
, 1432 (2005)
Abstract
;
Full Text
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma:
V. Pomel, et al.; J. Med. Chem.
49
, 3857 (2006)
Abstract
;
Full Text
ALX-270-443
Revised 05-May-08
AS601245
SYNONYMS
1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile
JNK Inhibitor V
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-443-M001
1 mg
50.00 USD
ALX-270-443-M005
5 mg
150.00 USD
ALX-270-443-M025
25 mg
520.00 USD
Product Specification
FORMULA:
C
20
H
16
N
6
S
MW:
372.5
CAS NUMBER:
345987-15-7
PURITY:
≥95% (HPLC)
APPEARANCE:
White to yellow solid.
PURITY DETAIL:
Sum of two isomers.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Hygroscopic. Packaged under inert gas. Protect from light.
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC
50
=150nM, hJNK2: IC
50
=220nM and hJNK3: IC
50
=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
Product Specific Literature References
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties:
S. Carboni, et al.; J. Pharmacol. Exp. Ther.
310
, 25 (2004)
Abstract
;
Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase:
P. Gaillard, et al.; J. Med. Chem.
48
, 4596 (2005)
Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Anti-inflammatory Agents Other Products
ALX-270-461
Revised 25-May-07
AS-604850
SYNONYMS
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-461-M001
1 mg
35.00 USD
ALX-270-461-M005
5 mg
130.00 USD
ALX-270-461-M025
25 mg
520.00 USD
Product Specification
FORMULA:
C
11
H
5
F
2
NO
4
S
MW:
285.2
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
MELTINGPOINT:
200-202°C
Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis:
M. Camps, et al.; Nat. Med.
11
, 936 (2005)
Abstract
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells:
A. Bilancio, et al.; Blood
107
, 642 (2006)
Abstract
;
Full Text
ALX-270-462
Revised 09-Oct-07
AS-605240
SYNONYMS
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-462-M001
1 mg
25.00 USD
ALX-270-462-M005
5 mg
80.00 USD
ALX-270-462-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
12
H
7
N
3
O
2
S
MW:
257.3
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
Pink to reddish brown solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis:
M. Camps, et al.; Nat. Med.
11
, 936 (2005)
Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus:
D.F. Barber, et al.; Nat. Med.
11
, 933 (2005)
Abstract
ALX-302-013
Revised 25-Jan-06
Asialo-GM1
SYNONYMS
Ceramide tetrahexoside
Gangliotetraosylceramide
Asialoganglioside-GM1
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Gangliosides / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-302-013-MC05
0.5 mg
110.00 USD
ALX-302-013-M001
1 mg
190.00 USD
Product Specification
SEQUENCE:
GgOse
4
Cer; β-Gal-(1→3)-β-GalNAc-(1→4)-β-Gal-(1→4)-β-Glc-(1→1')-Cer
FORMULA:
C
62
H
113
N
2
O
23
MW:
1254.6 (calculated on sphingosine C18:1 and stearic acid)
CAS NUMBER:
71012-19-6
SOURCE/HOST:
Semisynthetic (from GM1).
PURITY:
≥98%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
ALX-302-014
Revised 13-Dec-04
Asialo-GM1 (cell culture grade)
SYNONYMS
Asialoganglioside-GM1 (cell culture grade)
Ceramide tetrahexoside (cell culture grade)
Gangliotetraosylceramide (cell culture grade)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Gangliosides / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-302-014-MC05
0.5 mg
150.00 USD
Product Specification
SEQUENCE:
GgOse
4
Cer; β-Gal-(1→3)-β-GalNAc-(1→4)-β-Gal-(1→4)-β-Glc-(1→1')-Cer
FORMULA:
C
62
H
113
N
2
O
23
MW:
1254.6 (calculated on sphingosine C18:1 and stearic acid)
CAS NUMBER:
71012-19-6
SOURCE/HOST:
Semisynthetic (from GM1).
PURITY:
≥98%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
