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ALX-430-153
Revised 25-Mar-08
Zoledronic acid
SYNONYMS
1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
CGP 42446
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Bisphosphonates / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-153-M025
25 mg
80.00 USD
ALX-430-153-M100
100 mg
240.00 USD
ALX-430-153-G001
1 g
550.00 USD
Product Specification
FORMULA:
C
5
H
10
N
2
O
7
P
2
. H
2
O
MW:
272.1 . 18.0
CAS NUMBER:
118072-93-8; 165800-06-6
MERCK INDEX:
14:
10187
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of osteoclastic bone resorption. Prevents osteoporosis and skeletal fractures, particularly in patients with multiple myeloma or prostate cancer. Also used to treat hypercalcemia.
Product Specific Literature References
Preclinical pharmacology of CGP 42’446, a new, potent, heterocyclic bisphosphonate compound:
J.R. Green, et al.; J. Bone Miner. Res.
9
, 745 (1994)
Abstract
An enzyme inhibition assay for the quantitative determination of the new bisphosphonate zoledronate in plasma:
F. Risser, et al.; J. Pharm. Biomed. Anal.
15
, 1877 (1997)
Abstract
Clinical research update: zoledronate:
J.J. Body; Cancer
80
, 1699 (1997)
Abstract
;
Full Text
Intravenous zoledronic acid in postmenopausal women with low bone mineral density:
I.R. Reid, et al.; New Engl. J. Med.
346
, 653 (2002)
Abstract
A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma:
F. Saad, et al.; J. Natl. Cancer Inst.
94
, 1458 (2002)
Abstract
Zoledronic acid: an advance in tumour bone disease therapy and a new hope for osteoporosis:
J.J. Body; Expert Opin. Pharmacother.
4
, 567 (2003)
Abstract
Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis:
D.M. Black, et al.; New Engl. J. Med.
356
, 1809 (2007)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
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