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ALX-260-111
Revised 25-Jul-08
Ac-VEID-AFC
SYNONYMS
Caspase-6 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-111-M005
5 mg
157.00 USD
ALX-260-111-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Val-Glu-Ile-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
32
H
40
F
3
N
5
0
11
MW:
727.7
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic substrate for caspase-6.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-064
Revised 17-Jan-06
Ac-VEID-AMC
SYNONYMS
Caspase-6 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-064-M001
1 mg
32.00 USD
ALX-260-064-M005
5 mg
123.00 USD
Product Specification
SEQUENCE:
Ac-Val-Glu-Ile-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
32
H
43
N
5
O
11
MW:
673.8
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-6.
Product Specific Literature References
Cleavage of lamin A by Mch2alpha but not CPP32: multiple interleukin 1beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis:
A. Takahashi, et al.; PNAS
93
, 8395 (1996)
Abstract
Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis:
L.M. Martins, et al.; J. Biol. Chem.
272
, 7421 (1997)
Abstract
;
Full Text
Apoptosis by death factor:
S. Nagata; Cell
88
, 355 (1997)
Abstract
Substrate specificities of caspase family proteases
:
R.V. Talanian, et al.; J. Biol. Chem.
272
, 9677 (1997)
Abstract
;
Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B:
N.A. Thornberry, et al.; J. Biol. Chem.
272
, 17907 (1997)
Abstract
;
Full Text
Purification and catalytic properties of human caspase family members:
M. Garcia-Calvo, et al.; Cell Death Differ.
6
, 362 (1999)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-062
Revised 30-Oct-08
Ac-VEID-CHO
SYNONYMS
Caspase-6 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-062-M001
1 mg
83.00 USD
ALX-260-062-M005
5 mg
325.00 USD
Product Specification
SEQUENCE:
Ac-Val-Glu-Ile-Asp-CHO
FORMULA:
C
22
H
36
N
4
O
9
MW:
500.6
PEPTIDE CONTENT:
70-90%.
PURITY:
≥95% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. The solution is stable for weeks when stored at -20°C and protected from light. Do not dissolve in aqueous buffer due to possible racemization.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-6. Also inhibits caspase-8 and -10.
ALX-260-063
Revised 24-Feb-05
Ac-VEID-pNA
SYNONYMS
Caspase-6 Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-063-M001
1 mg
22.00 USD
ALX-260-063-M005
5 mg
83.00 USD
Product Specification
SEQUENCE:
Ac-Val-Glu-Ile-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
28
H
40
N
6
O
11
MW:
636.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-6.
Product Specific Literature References
Substrate specificities of caspase family proteases:
R.V. Talanian, et al.; J. Biol. Chem.
272
, 9677 (1997)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
ALX-260-117
Revised 31-Oct-07
Ac-WEHD-AFC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
Caspase-5 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-117-M005
5 mg
157.00 USD
ALX-260-117-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
38
H
37
F
3
N
8
O
11
MW:
838.8
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solution in DMSO is stable for 6-8 months when stored at -20°C.
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1 and -5. Also a substrate for caspase-4.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-057
Revised 25-Sep-07
Ac-WEHD-AMC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
Caspase-5 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-057-M001
1 mg
42.00 USD
ALX-260-057-M005
5 mg
123.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
38
H
40
N
8
O
11
MW:
784.8
PEPTIDE CONTENT:
70-90%
PURITY:
≥99% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
Product Description
Fluorogenic substrate for caspase-1 and -5. Also a substrate for caspase-4. This fluorogenic caspase-1 substrate with an optimal tetrapeptide sequence is cleaved 50-fold more efficiently than Ac-YVAD-AMC (Prod. No.
ALX-260-024
).
Product Specific Literature References
A combinatorial approach defines specificities of members of the caspase family and granzyme B:
N.A. Thornberry, et al.; J. Biol. Chem.
272
, 17907 (1997)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-055
Revised 23-Feb-07
Ac-WEHD-CHO
SYNONYMS
Caspase-1 Inhibitor (Aldehyde)
Caspase-5 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-055-M001
1 mg
97.00 USD
ALX-260-055-M005
5 mg
385.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Glu-His-Asp-CHO
FORMULA:
C
28
H
33
N
7
O
9
MW:
611.6
PURITY:
≥90% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
TFA salt.
SOLUBILITY:
Soluble in water (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solution is stable for 1 month when stored at -20°C and protected from light.
HANDLING:
Keep cool and dry.
Product Description
Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4.
Product Specific Literature References
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE):
T.A. Rano, et al.; Chem. Biol.
4
, 149 (1997)
Abstract
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis:
N.A. Thornberry, et al.; J. Biol. Chem.
272
, 17907 (1997)
Abstract
;
Full Text
ALX-260-082
Revised 24-Feb-05
Ac-WEHD-pNA
SYNONYMS
Caspase-1 Substrate (Chromogenic)
Caspase-5 Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-082-M001
1 mg
32.00 USD
ALX-260-082-M005
5 mg
93.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Glu-His-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
34
H
37
N
9
O
11
MW:
747.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5. Also soluble in buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-1 and -5. Also a substrate for caspase-4.
Product Specific Literature References
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis:
N.A. Thornberry, et al.; J. Biol. Chem.
272
, 17907 (1997)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
ALX-260-108
Revised 03-Jun-05
Ac-YVAD-AFC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-108-M005
5 mg
147.00 USD
ALX-260-108-M010
10 mg
275.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
33
H
36
F
3
N
5
O
10
MW:
719.7
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1 and -4.
Product Specific Literature References
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP:
M. Marcelli, et al.; Cancer Res.
58
, 76 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-024
Revised 17-Jan-06
Ac-YVAD-AMC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-024-M001
1 mg
37.00 USD
ALX-260-024-M005
5 mg
98.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA:
C
33
H
39
N
5
O
10
MW:
665.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1.
Product Specific Literature References
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes:
N.A. Thornberry, et al.; Nature
356
, 768 (1992)
Abstract
Interleukin-1 β converting enzyme:
N.A. Thornberry; Meth. Enzymol.
244
, 615 (1994)
Abstract
Crystal structure of the cysteine protease interleukin-1 β-converting enzyme: a (p20/p10)2 homodimer:
N.P.C. Walker, et al.; Cell
78
, 343 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-027
Revised 16-Dec-08
Ac-YVAD-CHO
SYNONYMS
Caspase-1 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-027-M001
1 mg
42.00 USD
