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ALX-350-346 Revised 12-Sep-08
Silybin
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SYNONYMS Silibinin
2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-346-G001   1 g 10.00 USD Add To Cart
ALX-350-346-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C25H22O10
MW: 482.4
CAS NUMBER: 22888-70-6; 65666-07-1
MERCK INDEX: 14: 8532
RTECS: DJ2981770
SOURCE/HOST: Originally isolated from Silybum marianum.
PURITY: ≥98%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in 100% ethanol (0.1mg/ml), DMSO (10mg/ml), dimethyl formamide (20mg/ml), acetone or methanol; 0.5mg/ml soluble in a 1:9 solution of dimethyl formamide:PBS (pH 7.2) (dilute the dimethyl formamide solution with PBS).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing aqueous solutions for more than one day.
HAZARD: IRRITANT.

Product Description
Mixture of silybin A and silybin B. Major active constituent of silymarin. Anti-inflammatory, cytoprotective and anti-cancer compound. Shows chemopreventive effect against skin cancer. Inhibits mitogen-activated protein kinase (MAPK). Inhibits P-glycoprotein (Pgp)-mediated cellular efflux. Inhibits cytochrome P450 enzymes. Apoptosis inducer. Blocks the production of superoxide in Kupffer cells (EC50=100µM). Antioxidant. Free radical scavenger.
Product Specific Literature References
[On the chemistry of silymarin (silybin), the active principle of the fruits from Silybum marianum (L.) Gaertn. (Carduus marianus L.)]: H. Wagner, et al.; Arzneimittelforschung 18, 688 (1968) Abstract
Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin: C. Dehmlow, et al.; Hepatology 23, 749 (1996) Abstract; Full Text
Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention: X. Zi & R. Agarwal; PNAS 96, 7490 (1999) Abstract; Full Text
The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein: M. Maitrejean, et al.; Bioorg. Med. Chem. Lett. 10, 157 (2000) Abstract
Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis: S. Dhanalakshmi, et al.; Oncogene 21, 1759 (2002) Abstract; Full Text
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells: C. Agarwal, et al.; Oncogene 22, 8271 (2003) Abstract; Full Text
Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line: L. Qi, et al.; Cancer Biol. Ther. 2, 526 (2003) Abstract; Full Text
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells: A.K. Tyagi, et al.; BBRC 312, 1178 (2003) Abstract
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages: A. Tyagi, et al.; Carcinogenesis 25, 1711 (2004) Abstract; Full Text
Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling: G. Mallikarjuna, et al.; Cancer Res. 64, 6349 (2004) Abstract; Full Text
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells: S. Dhanalakshmi, et al.; J. Biol. Chem. 280, 20375 (2005) Abstract; Full Text
Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway: P.N. Chen, et al.; J. Dent. Res. 85, 220 (2006) Abstract; Full Text
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences: C. Hoh, et al.; Clin. Cancer Res. 12, 2944 (2006) Abstract; Full Text
Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway: L.H. Li, et al.; Biol. Pharm. Bull. 29, 1096 (2006) Abstract; Full Text
Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells: R.P. Singh, et al.; Mol. Cancer Ther. 5, 1145 (2006) Abstract; Full Text
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2: A. Tyagi, et al.; Carcinogenesis 27, 2269 (2006) Abstract; Full Text
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells: C. Agarwal, et al.; Carcinogenesis 28, 1463 (2007) Abstract
Effects and mechanisms of silibinin on human hepatoma cell lines: J.J. Lah, et al.; World J. Gastroenterol. 13, 5299 (2007) Abstract; Full Text
Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells: S.O. Lee, et al.; BBRC 354, 165 (2007) Abstract
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis: K. Min, et al.; Arch. Pharm. Res. 30, 1265 (2007) Abstract
Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivi: Y.G. Son, et al.; Cancer Res. 67, 8274 (2007) Abstract
Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells: A. Tyagi, et al.; Pharm. Res. Epub ahead of print, (2008) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Flavanones • MAPK Pathway Inhibitors • Cytochrome P450 [CYP450] / Related Products • Natural Products - Antioxidants • MDR Inhibitors • P-glycoprotein [Pgp] / Related Products • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-385-018 Revised 03-Dec-07
(+)-Taxifolin
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SYNONYMS (+)-Dihydroquercetin
(+)-3,3',4',5,7-Pentahydroxyflavanone
Taxifoliol
Distylin
Catechin hydrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-018-M010   10 mg 35.00 USD Add To Cart
ALX-385-018-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H12O7
MW: 304.3
CAS NUMBER: 17654-26-1
PURITY: ≥96%
APPEARANCE: Light yellow to brown powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Anti-inflammatory compound. Chemopreventive agent. Decreases hepatic lipid synthesis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid: A. Theriault, et al.; J. Lipid Res. 41, 1969 (2000) Abstract
Prevention of macrophage adhesion molecule-1 (Mac-1)-dependent neutrophil firm adhesion by taxifolin through impairment of protein kinase-dependent NADPH oxidase activation and antagonism of G protein-mediated calcium influx: Y.H. Wang, et al.; Biochem. Pharmacol. 67, 2251 (2004) Abstract
The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation: S.B. Lee, et al.; Biol. Pharm. Bull. 30, 1074 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents
 
 
ALX-385-006 Revised 03-Dec-07
(±)-Taxifolin
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SYNONYMS (±)-Dihydroquercetin
(±)-3,3',4',5,7-Pentahydroxyflavanone
Taxifoliol
Distylin
Catechin hydrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-006-M010   10 mg 50.00 USD Add To Cart
ALX-385-006-M050   50 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H12O7
MW: 304.3
CAS NUMBER: 480-18-2
RTECS: LK6920000
PURITY: ≥90%
APPEARANCE: White to faintly yellow powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antioxidant flavonoid.
Product Specific Literature References
Suppression of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45, 265 (1993) Abstract
Suppression of hydroperoxide-induced cytotoxicity by polyphenols: T. Nakayama; Cancer Res. 54, 1991s (1994) Abstract
Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study: W. Bors, et al.; Free Radic. Biol. Med. 19, 45 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid: A. Theriault, et al.; J. Lipid Res. 41, 1969 (2000) Abstract
Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretionInhibitory activity of diacylglycero: A. Casaschi, et al.; Atherosclerosis 176, 247 (2004) Abstract
Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-350-305 Revised 08-Apr-08
Tiliroside
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-305-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C30H26O13
MW: 594.5
CAS NUMBER: 20316-62-5
SOURCE/HOST: Isolated from Tilia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Flavonoid which shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages. Shows potent activity against d-GalN-induced cytotoxicity in hepatocytes. Cytotoxic against specific leukaemic cell lines. Inhibits LDL oxidation. Antibacterial and antifungal.
Product Specific Literature References
Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii: K.Y. Jung, et al.; Biol. Pharm. Bull. 21, 1077 (1998) Abstract
Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines: K. Dimas, et al.; Leuk. Res. 23, 1021 (1999) Abstract
Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action: H. Matsuda, et al.; Bioorg. Med. Chem. 10, 707 (2002) Abstract
Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside: A. Sala, et al.; Eur. J. Pharmacol. 461, 53 (2003) Abstract
Flavonoids from the leaves of Litsea japonica and their anti-complement activity: S.Y. Lee, et al.; Phytother. Res. 19, 273 (2005) Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005) Abstract; Full Text
Antiviral and antimicrobial assessment of some selected flavonoids: B. Ozcelik, et al.; Z. Naturforsch. [C] 61, 632 (2006) Abstract
Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation: G.R. Schinella, et al.; Fitoterapia 78, 1 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents • Natural Products - Antitumor Reagents • Flavonols • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Complement System Other Products
 
 
ALX-460-018 Revised 08-Apr-08
DL-α-Tocopherol (high purity)
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SYNONYMS Vitamin E (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-018-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C29H50O2
MW: 430.7
CAS NUMBER: 10191-41-0
MERCK INDEX: 14: 9495
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Slightly yellow viscous oil.
SOLUBILITY: Soluble in 100% ethanol, ether, chloroform, acetone or vegetable oils.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable to heat and alkalis.
HANDLING: Protect from light.

Product Specific Literature References
Suppression of nitric oxide toxicity in islet cells by alpha-tocopherol: V. Burkart, et al.; FEBS Lett. 364, 259 (1995) Abstract
Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-460-019 Revised 24-Oct-07
DL-α-Tocopherol . acetate
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SYNONYMS Vitamin E . acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-019-G005   5 g 23.00 USD Add To Cart
Product Specification
FORMULA: C31H52O3
MW: 472.8
CAS NUMBER: 7695-91-2
MERCK INDEX: 14: 9495
RTECS: GA8747000
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow-greenish liquid.
SOLUBILITY: Soluble in methanol or 96% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-385-030 Revised 12-Sep-08
Trihydroxyethylrutin
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SYNONYMS Troxerutin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-030-G005   5 g 30.00 USD Add To Cart
ALX-385-030-G025   25 g 90.00 USD Add To Cart
Product Specification
FORMULA: C33H42O19
MW: 742.7
CAS NUMBER: 7085-55-4
MERCK INDEX: 14: 9789
RTECS: LK8331500
SOURCE/HOST: Semisynthetic.
PURITY: ≥95% (Assay)
APPEARANCE: Light yellow to greenish powder.
SOLUBILITY: Soluble in water, glycerol or propylene glycol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
More orally active than rutin (Prod. No. ALX-460-028). Vaso- and cardioprotective agent used clinically to treat venous disorders. Inhibits platelet aggregation. Protects biomembranes and DNA against the deleterious effects of γ-radiation. Free radical scavenger. Antioxidant.
Product Specific Literature References
Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro: J. Swies, et al.; Pol. J. Pharmacol. Pharm. 36, 455 (1984) Abstract
Effect of troxerutin and methionine on spin trapping of free oxy-radicals: I.E. Blasig, et al.; Biomed. Biochim. Acta 47, S252 (1988) Abstract
Free radical scavenging and skin penetration of troxerutin and vitamin derivatives: M. Kessler, et al.; J. Dermatolog. Treat. 13, 133 (2002) Abstract
Radioprotection of normal tissues in tumor-bearing mice by troxerutin: D.K. Maurya, et al.; J. Radiat. Res. 45, 221 (2004) Abstract; Full Text
Protection of cellular DNA from gamma-radiation-induced damages and enhancement in DNA repair by troxerutin: D.K. Maurya, et al.; Mol. Cell. Biochem. 280, 57 (2005) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Antioxidants
 
 
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