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ALX-350-016
Revised 31-Jul-08
(+)-Aphidicolin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cell Cycle Research
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Product Numbers:
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ALX-350-016-M001
1 mg
65.00 USD
ALX-350-016-M005
5 mg
260.00 USD
ALX-350-016-M025
25 mg
890.00 USD
Product Specification
FORMULA:
C
20
H
34
O
4
MW:
338.5
CAS NUMBER:
38966-21-1
MERCK INDEX:
14:
727
RTECS:
PB9185000
SOURCE/HOST:
Isolated from
Nigrospora oryzae.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (50mg/ml), methanol (10mg/ml) or 100% ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
Product Specific Literature References
X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system:
K.M. Brundret, et al.; J. C. S. Chem. Commun. 1027 (1972)
The production of aphidicolin by Nigrospora sphaerica:
A.N. Starratt and S.R Loschiavo; Can. J. Microbiol.
20
, 416 (1974)
Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha:
S. Ikegami, et al.; Nature
275
, 458 (1978)
Abstract
Inhibition by aphidicolin of cell cycle progression and DNA replication in sea urchin embryos:
S. Ikegami, et al.; J. Cell. Physiol.
100
, 439 (1979)
Abstract
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha:
J.A. Huberman; Cell
23
, 647 (1981)
Abstract
Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes:
S. Spadari, et al.; TIBS
7
, 29 (1982)
Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines:
K. Kuwakado, et al.; Biochem. Pharmacol.
46
, 1909 (1993)
Abstract
Life, death and genomic change in perturbed cell cycles:
R.T. Schimke, et al.; Philos. Trans. R. Soc. London B Biol. Sci.
345
, 311 (1994)
Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization:
L. Urbani, et al.; Exp. Cell. Res.
219
, 159 (1995)
Abstract
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3:
M.M. Borner, et al.; Cancer Res.
55
, 2122 (1995)
Abstract
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells:
W. Poluha, et al.; Oncogene
10
, 185 (1995)
Abstract
Coordinate regulation of G- and C strand length during new telomere synthesis:
X. Fan and C.M. Price; Mol. Biol. Cell
8
, 2145 (1997)
Abstract
;
Full Text
Effect of aphidicolin on DNA methyltransferase in the nucleus:
I. Suetake, et al.; Cell Struct. Funct.
23
, 137 (1998)
Abstract
Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine:
M. Michaelis, et al.; Anticancer Drugs
11
, 479 (2000)
Abstract
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study:
B. Tedeschi, et al.; Mutat. Res.
546
, 55 (2004)
Abstract
Further Categories Containing This Product:
DNA Replication Inhibitors
•
Natural Products - Other Tumor Promoters
•
Carcinogens & Tumor Promoters Other Products
•
Natural Products - DNA Replication Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-095
Revised 03-Apr-08
Apicidin
SYNONYMS
cyclo
-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
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ALX-350-095-M001
1 mg
50.00 USD
ALX-350-095-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
34
H
49
N
5
O
6
MW:
623.8
CAS NUMBER:
183506-66-3
SOURCE/HOST:
Isolated from
Fusarium sp.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC.
Product Description
Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest. Stimulates apoptosis of cancer cells. Antiprotozoal.
Product Specific Literature References
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase
:
S.J. Darkin-Rattray, et al.; PNAS
93
, 13143 (1996)
Abstract
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin
:
J.W. Han, et al.; Cancer Res.
60
, 6068 (2000)
Abstract
Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor
:
J.S. Kim, et al.; BBRC
281
, 866 (2001)
Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1
:
S.L. Colletti, et al.; Bioorg. Med. Chem. Lett.
11
, 107 (2001)
Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2
:
S.L. Colletti, et al.; Bioorg. Med. Chem. Lett.
11
, 113 (2001)
Abstract
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities
:
S.B. Singh, et al.; J. Org. Chem.
67
, 815 (2002)
Abstract
Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells
:
J. Hong, et al.; Cancer Lett.
189
, 197 (2003)
Abstract
Activation of NF-kappaB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis:
Y.K. Kim, et al.; Cell Death Differ.
13
, 2033 (2006)
Abstract
Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells:
T. Ueda, et al.; Int. J. Mol. Med.
19
, 301 (2007)
Abstract
Further Categories Containing This Product:
HDAC Inhibitors
•
Natural Products - Other Anti-infective Agents
•
Parasitic Diseases Other Products
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products for Cell Cycle Research
ALX-350-375
Revised 22-Jul-08
Arcyriaflavin A
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
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ALX-350-375-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
20
H
11
N
3
O
2
MW:
325.3
CAS NUMBER:
118458-54-1
SOURCE/HOST:
Synthetic. Originally isolated from the marine ascidian
Eudistoma
sp.
PURITY:
≥95% (HPLC)
APPEARANCE:
Orange to red solid.
SOLUBILITY:
Soluble in DMSO (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Protect from light. Packaged under inert gas.
Product Description
Potent inhibitor of CDK4 / cyclin D1 (IC
50
= 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC
50
= 200nM).
Product Specific Literature References
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp:
P.A. Horton, et al.; Experientia
50
, 843 (1994)
Abstract
Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication:
M.J. Slater, et al.; Bioorg. Med. Chem.
7
, 1067 (1999)
Abstract
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors:
C. Sanchez-Martinez, et al.; Bioorg. Med. Chem. Lett.
13
, 3835 (2003)
Abstract
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors:
G. Zhu, et al.; Bioorg. Med. Chem. Lett.
13
, 1231 (2003)
Abstract
Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2:
R. Liu, et al.; Arch. Pharm. Res.
30
, 270 (2007)
Abstract
Further Categories Containing This Product:
Natural Products for Cell Cycle Research
•
Antiviral Agents Other Products
•
Marine Natural Products
ALX-350-273
Revised 03-Apr-08
3-ATA
SYNONYMS
3-Amino-9-thio(10
H
)-acridone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cell Cycle Research
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Format:
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ALX-350-273-M001
1 mg
60.00 USD
ALX-350-273-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
13
H
10
N
2
S
MW:
226.3
CAS NUMBER:
12982-10-85
PURITY:
≥95%
APPEARANCE:
White solid powder.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Specific CDK4 inhibitor (IC
50
=3.1µM) inducing growth inhibition of p16-altered tumors.
Product Specific Literature References
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4:
A. Kubo, et al.; Clin. Cancer Res.
5
, 4279 (1999)
Abstract
3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons:
E. Verdaguer, et al.; Neuroscience
120
, 599 (2003)
Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
ALX-385-022
Revised 07-Oct-08
Baicalein
SYNONYMS
5,6,7-Trihydroxyflavone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavones
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ALX-385-022-M005
5 mg
25.00 USD
ALX-385-022-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
15
H
10
O
5
MW:
270.2
CAS NUMBER:
491-67-8
MERCK INDEX:
14:
942
PURITY:
≥97%
APPEARANCE:
Yellow to yellow-green crystalline powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca
2+
uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.
Product Specific Literature References
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells:
J.L. Nadler, et al.; J. Clin. Invest.
80
, 1763 (1987)
Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone:
K. Ono, et al.; BBRC
160
, 982 (1989)
Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats:
K. Abe, et al.; Chem. Pharm. Bull.
38
, 209 (1990)
Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells:
H.C. Huang, et al.; Eur. J. Pharmacol.
268
, 73 (1994)
Abstract
Protective effects of baicalein against cell damage by reactive oxygen species:
D. Gao, et al.; Chem. Pharm. Bull. (Tokyo)
46
, 1383 (1998)
Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
:
S.L. Hsu, et al.; Eur. J. Pharmacol.
425
, 165 (2001)
Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes:
Y.C. Shen, et al.; Eur. J. Pharmacol.
465
, 171 (2003)
Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells:
H.Z. Lee, et al.; Anticancer Res.
25
, 959 (2005)
Abstract
Biological properties of baicalein in cardiovascular system:
Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord.
5
, 177 (2005), (Review)
Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression:
H.Y. Lin, et al.; Biochim. Biophys. Acta
1773
, 1073 (2007)
Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
•
Tyrosine Kinase Inhibitors
•
Natural Products for Angiogenesis Research
•
Natural Products - Protein Kinase Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Antioxidants
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products for Cell Cycle Research
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Lipoxygenases / Related Products
ALX-550-322
Revised 11-Nov-08
Caffeine
SYNONYMS
1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
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ALX-550-322-G005
5 g
10.00 USD
Product Specification
FORMULA:
C
8
H
10
N
4
O
2
MW:
194.2
CAS NUMBER:
58-08-2
MERCK INDEX:
14:
1636
SOURCE/HOST:
Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
PURITY:
≥99%
APPEARANCE:
White to colorless powder.
SOLUBILITY:
Soluble in chloroform, 100% alcohol or hot water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by NIR.
Product Description
CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.
Product Specific Literature References
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors:
J.W. Daly, et al.; J. Med. Chem.
29
, 1305 (1986)
Abstract
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action:
J. Sawynok & T.L. Yaksh; Pharmacol. Rev.
45
, 43 (1993)
Abstract
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells:
F. Traganos, et al.; Cancer Res.
53
, 4613 (1993)
Abstract
Multiple effects of caffeine on calcium current in rat ventricular myocytes:
I. Zahradnik & P. Palade; Pfluegers Arch.
424
, 129 (1993)
Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures:
T.G. Papaioannou, et al.; Am. J. Hypertens.
18
, 129 (2005), (Review)
Abstract
Caffeine and the dopaminergic system:
O. Cauli & M. Morelli; Behav. Pharmacol.
16
, 63 (2005), (Review)
Abstract
Immunomodulatory effects of caffeine: friend or foe:
L. A. Horrigan, et al.; Pharmacol. Ther.
111
, 877 (2006), (Review)
Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease:
A. Kalda, et al.; J. Neurol. Sci.
248
, 9 (2006), (Review)
Abstract
The enigmatic effects of caffeine in cell cycle and cancer:
A. M. & Bode and Z. Dong; Cancer Lett.
247
, 26 (2007), (Review)
Abstract
Further Categories Containing This Product:
Neuroactive Agents Other Products
•
Ca2+ Modulators
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Phosphodiesterases / Related Products
•
Natural Products - Chemopreventive Agents
•
Other Natural Products - DNA Regulation / Transcription
•
Natural Products - Anti-inflammatory Agents
•
Alkaloids
•
Active Substances from Fruit and Vegetables
•
Natural Products for Cell Cycle Research
•
Natural Products - Other Signal Transduction Pathway Modulators
•
DNA Repair Other Products
ALX-550-516
Revised 21-May-08
Compound A
SYNONYMS
CpdA
2-((4-Acetophenyl)-2-chloro-
N
-methyl)ethylammonium chloride
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
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Product Numbers:
Format:
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Unit Price:
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ALX-550-516-M005
5 mg
40.00 USD
ALX-550-516-M025
25 mg
120.00 USD
Product Specification
FORMULA:
C
11
H
14
ClNO
2
. HCl
MW:
227.7 . 36.5
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING:
Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.
Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No.
ALX-370-002
) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes
in vivo
.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression:
K. De Bosscher, et al.; PNAS
102
, 15827 (2005)
Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis:
P. Dewint, et al.; J. Immunol.
180
, 2608 (2008)
Abstract
Related Products
ALX-370-002
Dexamethasone
Further Categories Containing This Product:
GITR & GITRL Other Products
•
RANK & RANKL / OPG Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Glucocorticoids & Glucocorticoid Receptors / Related Products
•
Antitumor Agents (Hormone-related)
•
DNA & RNA Methyl & Alkyl Transferases / Related Products
•
Other Natural Products - DNA Regulation / Transcription
•
Natural Products - Chemopreventive Agents
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products for Cell Cycle Research
ALX-350-290
Revised 18-Nov-08
Debromohymenialdisine
SYNONYMS
DBH
4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-
c
]azepin-8-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-350-290-C100
100 µg
90.00 USD
Product Specification
FORMULA:
C
11
H
11
N
5
O
2
MW:
245.2
CAS NUMBER:
75593-17-8, 125118-55-0
SOURCE/HOST:
Isolated from sponge
Axinella carteri
.
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Inhibitor of G2 DNA damage checkpoint (IC
50
=8µM) and check point kinases 1 (Chk1) (IC
50
=3µM) and 2 (Chk2) (IC
50
=3.5µM) [1,3]. Unlike other checkpoint inhibitors DBH does not inhibit
ataxia-telangiectasia
mutated (ATM) or ATM-Rad3-related protein. Also inhibits MAP kinase kinase 1 (MEK-1) (IC
50
=881nM) but is not as potent as 10Z-hymenialdisine (Prod. No.
ALX-350-289
) (IC
50
=6nM) [2].
Product Specific Literature References
[1]
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine
:
D. Curman, et al.; J. Biol. Chem.
276
, 17914 (2001)
Abstract
;
Full Text
[2]
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
:
D. Tasdemir, et al.; J. Med. Chem.
45
, 529 (2002)
Abstract
[3]
G2 checkpoint abrogators as anticancer drugs:
T. Kawabe; Mol. Cancer Ther.
3
, 513 (2004)
Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors
•
Alkaloids
•
Natural Products for Cell Cycle Research
•
Marine Natural Products
•
Chk1 & Chk2 / Related Products
ALX-270-300
Revised 05-Apr-08
Fascaplysin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cell Cycle Research
Ordering Information
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Format:
Size:
Unit Price:
Quantity:
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ALX-270-300-M001
1 mg
60.00 USD
ALX-270-300-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
18
H
11
N
2
OCl
MW:
306.8
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
Brown powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Protect from light.
HAZARD:
TOXIC.
Product Description
Originally isolated from a marine sponge. Selective CDK4/cyclin D1 (IC
50
=350nM) inhibitor (in an ATP competitive manner).
Product Specific Literature References
Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sponge
:
D.M. Roll, et al.; J. Org. Chem.
53
, 3276 (1988)
A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta:
G. Kirsch, et al.; J. Nat. Prod.
63
, 825 (2000)
Abstract
Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product:
R. Soni, et al.; BBRC
275
, 877 (2000)
Abstract
DNA binding properties of the marine sponge pigment fascaplysin
:
A. Hormann, et al.; Bioorg. Med. Chem.
9
, 917 (2001)
Abstract
Further Categories Containing This Product:
Marine Natural Products
•
CDK & Cyclin Inhibitors
•
Alkaloids
ALX-350-124
Revised 05-Apr-08
Ferulenol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products with Antibiotic Activity
Ordering Information
Product Numbers:
Format:
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ALX-350-124-M001
1 mg
45.00 USD
ALX-350-124-M005
5 mg
135.00 USD
ALX-350-124-M010
10 mg
230.00 USD
Product Specification
FORMULA:
C
24
H
30
O
3
MW:
366.5
CAS NUMBER:
6805-34-1
SOURCE/HOST:
Isolated from
Ferula communis
.
PURITY:
≥96%
