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Myelin Basic Protein / Related Products
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ALX-151-024 Revised 03-Mar-05
H-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-024-M001   1 mg 95.00 USD Add To Cart
ALX-151-024-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C39H70N18O11
MW: 967.1
PURITY: ≥98%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for myelin basic protein kinase (p44mpk) and for MAP kinase (MAPK/ERK).
Product Specific Literature References
Identification of the sites in myelin basic protein that are phosphorylated by meiosis-activated protein kinase p44mpk: J.S. Sanghera, et al.; FEBS Lett. 273, 223 (1990) Abstract
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase: I. Clark-Lewis, et al.; J. Biol. Chem. 266, 15180 (1991) Abstract; Full Text
M. Daeipour, et al.; J. Immunol. 150, 4743 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-270-084 Revised 28-Jan-05
ML-9 . hydrochloride
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SYNONYMS 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-084-M010   10 mg 65.00 USD Add To Cart
ALX-270-084-M025   25 mg 125.00 USD Add To Cart
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Product Specification
FORMULA: C15H17ClN2O2S . HCl
MW: 324.8 . 36.5
CAS NUMBER: 105637-50-1
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of myosin light chain kinase, protein kinase C (PKC) and protein cAMP-dependent protein kinase (PKA). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Product Specific Literature References
The modulatory role of myosin light chain phosphorylation in human platelet activation [published erratum appears in Biochem Biophys Res Commun 1987 Jan 15;142(1):287]: M. Saitoh, et al.; BBRC 140, 280 (1986) Abstract
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; BBRC 143, 1045 (1987) Abstract
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987) Abstract; Full Text
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol. 195, 267 (1991) Abstract
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res. 18, 317 (1993) Abstract
Further Categories Containing This Product:
PKA Inhibitors • PKC Inhibitors • Myosin Light Chain Kinase Inhibitors
 
 
ALX-202-076 Revised 04-Jul-07
Myelin Basic Protein (bovine) (high purity)
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SYNONYMS MBP (bovine) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-202-076-M001   1 mg 30.00 USD Add To Cart
ALX-202-076-M005   5 mg 120.00 USD Add To Cart
ALX-202-076B-M001 Biotin 1 mg 180.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from bovine central nervous system tissue by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least 6 months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
MAPK Pathway Substrates • CAM Kinase Substrates • Natural Proteins
 
 
ALX-162-009 Revised 04-Jul-07
Myelin Basic Protein (4-14) (bovine)
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SYNONYMS MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-009-M001   1 mg 85.00 USD Add To Cart
ALX-162-009-M005   5 mg 330.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H103N21O17
MW: 1390.6
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific and convenient substrate for protein kinase C (PKC). Very poor substrate for phosphorylase kinase, CaM kinase II, casein kinases I and II and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts: Y.J.K. Farrar, et al.; BBRC 180, 694 (1991) Abstract
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-162-016 Revised 04-Jul-07
[Pyr4]-Myelin Basic Protein (4-14) (bovine)
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SYNONYMS [Pyr4]-MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-016-M001   1 mg 95.00 USD Add To Cart
ALX-162-016-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H100N20O17
MW: 1373.6
CAS NUMBER: 136132-68-8
PURITY: ≥96%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for protein kinase C (PKC).
Product Specific Literature References
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Peptide fragments of myelin basic protein as substrates of protein kinase C: M. Eller, et al.; Biochem. Int. 27, 625 (1992) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-010 Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)
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SYNONYMS MBP (104-118) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-010-M001   1 mg 95.00 USD Add To Cart
ALX-162-010-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
FORMULA: C70H111N23O19
MW: 1578.8
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein: R.S. Turner, et al.; J. Biol. Chem. 260, 11503 (1985) Abstract; Full Text
Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C): H. Su, et al.; BBRC 134, 78 (1986) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-200-606 Revised 08-May-08
Myelin Basic Protein (human) (high purity)
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SYNONYMS MBP (human) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-200-606-M001   1 mg 350.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from human brain by method of Määttä et al. [1].
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE; Immunoblot)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure: V. Majava, et al.; BMC Struct. Biol. 8, 10 (2008) Abstract; Full Text
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley. MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
CAM Kinase Substrates • Natural Proteins • MAPK Pathway Substrates
 
 
ALX-162-033 Revised 04-Jul-07
Myelin Basic Protein (87-99) (human, bovine, rat)
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SYNONYMS MBP (87-99) (human, bovine, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-033-M001   1 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-OH
FORMULA: C74H114N20O17
MW: 1555.8
PURITY: ≥85% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: <1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
General Information
MANUFACTURER Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases: F. Lolli, et al.; Curr. Protein Pept. Sci. 4, 277 (2003) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-019 Revised 04-Jul-07
[Ala96]-Myelin Basic Protein (87-99) (human, bovine, rat)
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SYNONYMS [Ala96]-MBP (87-99) (human, bovine, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-019-M001   1 mg 80.00 USD Add To Cart
ALX-162-019-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Ala-Arg-Thr-Pro-OH
FORMULA: C72H112N20O17
MW: 1529.8
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein: S. Brocke, et al.; Nature 379, 343 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-202-075 Revised 20-Sep-06
Myelin Basic Protein (mouse) (high purity)
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SYNONYMS MBP (mouse) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-075-M001   1 mg 120.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from mouse central nervous system tissue by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24h at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
MAPK Pathway Substrates • CAM Kinase Substrates • Natural Proteins
 
 
ALX-202-077 Revised 22-Aug-06
Myelin Basic Protein (porcine) (high purity)
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SYNONYMS MBP (porcine) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-077-M001   1 mg 35.00 USD Add To Cart
ALX-202-077-M005   5 mg 140.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from porcine brain by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Description