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ALX-380-217
Revised 08-Apr-08
Reveromycin B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-217-MC25
0.25 mg
320.00 USD
Product Specification
FORMULA:
C
36
H
52
O
11
MW:
660.8
CAS NUMBER:
144860-68-4
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5344.
PURITY:
≥90% (HPLC)
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in acidic conditions.
Product Description
Antibiotic. Much less active analog of reveromycin A (Prod. No.
ALX-380-216
), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Useful negative control in resolving the mode of action of this class.
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1409 (1992)
Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1414 (1992)
Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products
•
Antibiotics - Antifungal
•
EGFR Kinase Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-380-218
Revised 08-Apr-08
Reveromycin C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-218-MC25
0.25 mg
320.00 USD
Product Specification
FORMULA:
C
37
H
54
O
11
MW:
674.8
CAS NUMBER:
144860-69-5
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5344.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in acidic conditions.
Product Description
Antibiotic. Minor component of the reveromycin complex with similar biological profile as reveromycin A (Prod. No.
ALX-380-216
), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Generally more potent than reveromycin A. Inhibitor of the mitogenic activity of epidermal growth factor (EGF).
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1409 (1992)
Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1414 (1992)
Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products
•
EGFR Kinase Inhibitors
•
Antibiotics - Antifungal
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-380-219
Revised 08-Apr-08
Reveromycin D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-219-MC25
0.25 mg
320.00 USD
Product Specification
FORMULA:
C
37
H
54
O
11
MW:
674.8
CAS NUMBER:
144860-70-8
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5344.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in acidic conditions.
Product Description
Antibiotic. Minor component of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). More active than its straight chain analog reveromycin C (Prod. No.
ALX-380-218
).
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1409 (1992)
Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1414 (1992)
Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products
•
EGFR Kinase Inhibitors
•
Antibiotics - Antifungal
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-270-129
Revised 18-Jan-08
Tyrphostin AG 18
SYNONYMS
Tyrphostin A23
Tyrphostin RG 50858
Tyrphostin RG 50810
(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-129-M005
5 mg
35.00 USD
ALX-270-129-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
2
MW:
186.2
CAS NUMBER:
118409-57-7
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation:
R.M. Lyall, et al.; J. Biol. Chem.
264
, 14503 (1989)
Abstract
;
Full Text
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini:
R.D. Duan & J.A. Williams; Am. J. Physiol.
267
, G401 (1994)
Abstract
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex:
S. Kapas, et al.; Biochem. J.
305
, 433 (1995)
Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein- tyrosine kinase:
R. Seger, et al.; J. Biol. Chem.
270
, 28325 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-143
Revised 20-Feb-08
Tyrphostin AG 494
SYNONYMS
Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-143-M005
5 mg
25.00 USD
ALX-270-143-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
12
N
2
O
3
MW:
280.3
CAS NUMBER:
133550-35-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Tyrphostin AG 494 blocks Cdk2 activation:
N. Osherov & A. Levitzki; FEBS Lett.
410
, 187 (1997)
Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase:
N. Kleinberger-Doron, et al.; Exp. Cell Res.
241
, 340 (1998)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
EGFR Kinase Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-059
Revised 11-Dec-04
Tyrphostin AG 537
SYNONYMS
Bis-Tyrphostin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-059-M005
5 mg
65.00 USD
ALX-270-059-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
23
H
20
N
4
O
6
MW:
448.4
PURITY:
≥98%
APPEARANCE:
Solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Description
Competitively inhibits EGF receptor kinase autophosphorylation.
Product Specific Literature References
Tyrphostins as molecular tools and potential antiproliferative drugs:
A. Levitzki & C. Gilon; TIPS
12
, 171 (1991), (Review)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
ALX-270-142
Revised 11-Dec-04
Tyrphostin AG 555
SYNONYMS
Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-142-M005
5 mg
25.00 USD
ALX-270-142-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
MW:
322.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-146
Revised 11-Dec-04
Tyrphostin AG 556
SYNONYMS
Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-146-M005
5 mg
25.00 USD
ALX-270-146-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
20
N
2
O
3
MW:
336.4
CAS NUMBER:
133550-41-1
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-144
Revised 07-Dec-04
Tyrphostin AG 835
SYNONYMS
Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-144-M005
5 mg
25.00 USD
ALX-270-144-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-37-5
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-035
Revised 07-Dec-04
Tyrphostin AG 1295
SYNONYMS
6,7-Dimethyl-2-phenylquinoxaline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-035-M001
1 mg
30.00 USD
ALX-270-035-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
16
H
14
N
2
MW:
234.3
CAS NUMBER:
71897-07-9
PURITY:
≥98%
APPEARANCE:
Tan solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
&nb
