ALEXIS Biochemicals: Monoclonal Antibody to TRAIL (human) (III6F)

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ALX-804-246

Revised 10-Mar-08

Monoclonal Antibody to SLAM (human) (IPO-3)
SYNONYMS	anti-CD150 (human) MAb (IPO-3)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD150 [SLAM; IPO-3] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-246-C100		100 µg	395.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	IPO-3
ISOTYPE:	Mouse IgG1
CONCENTRATION:	~1mg/ml
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2. Contains no sodium azide.
IMMUNOGEN:	Activated B cells.
SPECIFICITY:	Recognizes human SLAM (CD150).
APPLICATION:	ELISA (1:750) Flow Cytometry (1:750) Immunocytochemistry Immunohistochemistry (frozen sections (1:75)) Immunoprecipitation Functional Application (Cross-linking of surface receptors) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Monoclonal antibodies IPO-3 and IPO-10 against human B cell differentiation antigens: V.G. Pinchouk, et al.; Anticancer Res. 8, 1377 (1988) Abstract
Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping: S.P. Sidorenko, et al.; Neoplasma 39, 3 (1992) Abstract
Characterization of a cell surface glycoprotein IPO-3, expressed on activated human B and T lymphocytes: S.P. Sidorenko & E.A. Clark; J. Immunol. 151, 4614 (1993) Abstract
Immunodeficiency virus cDNA synthesis in resting T lymphocytes is regulated by T cell activation signals and dendritic cells: P.S. Polacino, et al.; J. Med. Primatol. 25, 201 (1996) Abstract
CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis: S.V. Mikhalap, et al.; J. Immunol. 162, 5719 (1999) Abstract; Full Text
SLAM (CDw150) is a cellular receptor for measles virus: H. Tatsuo, et al.; Nature 406, 893 (2000) Abstract
CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A: L.M. Shlapatska, et al.; J. Immunol. 166, 5480 (2001) Abstract; Full Text
The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells: S.V. Mikhalap, et al.; Blood 104, 4063 (2004) Abstract; Full Text

General Information

SLAM (CDw150) is present on the surface of T and B cells, and is a self-ligand mediating T and B cell interactions. Absence of an inhibitor (SAP) which blocks recruitment of the signal transduction molecule SHP-2 to its docking site in the SLAM cytoplasmic region is associated with X-linked lymphoproliferative disease [1].

General Literature References

[1] The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM : J. Sayos, et al.; Nature 395, 462 (1998) Abstract

Further Categories Containing This Product:

Natural Killer T [NKT] Cells / Related Products • Monoclonal Antibodies • CD Antibodies

ALX-804-153

Revised 01-Sep-05

Monoclonal Antibody to TACI (human) (1A1)
SYNONYMS	anti-Transmembrane Activator and CAML Interactor (human) MAb (1A1) anti-TNFRSF 13B (human) MAb (1A1) anti-CD267 (human) MAb (1A1)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	TACI

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-153-C050		50 µg	230.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	1A1
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS.
IMMUNOGEN:	Rat RBL cells expressing human TACI.
SPECIFICITY:	Recognizes human TACI.
APPLICATION:	Flow Cytometry Note: Not recommended for Immunohistochemistry.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells: L.G. Ng, et al.; J. Immunol. 173, 807 (2004) Abstract
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans: U. Salzer, et al.; Nat. Genet. 37, 820 (2005) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-800

Revised 28-Mar-08

Monoclonal Antibody to TACI (mouse) (8F10)
SYNONYMS	anti-Transmembrane Activator and CAML Interactor (mouse) MAb (8F10) anti-TNFRSF 13B (mouse) MAb (8F10) anti-CD267 (mouse) MAb (8F10)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	TACI

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-800-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	8F10
ISOTYPE:	Rat IgG2a
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS.
IMMUNOGEN:	Rat RBL cells expressing mouse TACI.
SPECIFICITY:	Recognizes mouse TACI.
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections) Functional Application (inhibition)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells: L.G. Ng, et al.; J. Immunol. 173, 807 (2004) Abstract
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers: N.D. Huntington, et al.; Nat. Immunol. 7, 190 (2006) Abstract
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo: Y. Diaz-de-Durana, et al.; Blood 107, 594 (2006 107, 594 (2006) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-805-085

Revised 12-Jul-07

Monoclonal Antibody to Thy-1 (human) (BC9-G2)
SYNONYMS	anti-CD90 (human) MAb (BC9-G2)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-085-L002		2 ml	330.00 USD

Product Specification

CLONE:	BC9-G2
ISOTYPE:	Mouse IgG3.
FORMULATION:	Liquid. Culture supernatant.
IMMUNOGEN:	Human Thy-1 (CD90) transfected CHO cells.
SPECIFICITY:	Recognizes human Thy-1. Detects a band of ~25-35kDa by Western blot.
APPLICATION:	Flow Cytometry Immunoprecipitation Western Blot Functional Application (Blocks Thy-1 mediated cell-cell adhesion)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

[1] Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005) Abstract
[2] Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90): A. Wetzel, et al.; J. Invest. Dermatol. 126, 441 (2006) Abstract
[3] Dermal fibroblasts induce maturation of dendritic cells: A. Saalbach, et al.; J. Immunol. 178, 4966 (2007) Abstract

General Information

Human Thy-1 is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation.

General Literature References

Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004) Abstract; Full Text

Further Categories Containing This Product:

Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products • Neurobiology & Neurodiseases Other Products • Monoclonal Antibodies

ALX-804-130

Revised 31-Oct-06

Monoclonal Antibody to Toll-like Receptor 1 (human) (GD2.F4)
SYNONYMS	anti-TLR1 (human) MAb (GD2.F4) anti-CD281 (human) MAb (GD2.F4)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-130-C100		100 µg	340.00 USD
ALX-804-130PF-C100	Preservative Free	100 µg	340.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	GD2.F4
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	GD2.F4: Liquid. In PBS containing 0.02% sodium azide. GD2.F4 (preservative free): Liquid. In PBS.
IMMUNOGEN:	Recombinant human soluble TLR1 (Toll-like receptor 1) extracellular domain.
SPECIFICITY:	Recognizes human TLR1. Does not cross-react with human TLR2 or TLR4.
APPLICATION:	Flow Cytometry (5-15µg/ml) Incubate with antibody at 37°C and then on ice with GAM-FITC.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Images

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Product Specific Literature References

Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses: D.H. Wyllie, et al.; J. Immunol. 165, 7125 (2000) Abstract; Full Text
Regulation of Toll-like receptors in human monocytes and dendritic cells: A. Visintin, et al.; J. Immunol. 166, 249 (2001) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Related Products

ALX-211-200	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (FITC)
ALX-211-202	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (Biotin)
ALX-211-201	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (R-PE)

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-323

Revised 31-Jul-07

Monoclonal Antibody to Toll-like Receptor 2 (human) (TL2.1)
SYNONYMS	anti-TLR2 (human) MAb (TL2.1) anti-Toll/Interleukin-1 Receptor-like Gene 4 (human) MAb (TL2.1) anti-TIL4 (human) MAb (TL2.1) anti-CD282 (human) MAb (TL2.1)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-323-C050		50 µg	230.00 USD
ALX-804-323PF-C050	Preservative Free	50 µg	230.00 USD
ALX-804-323PF-C100	Preservative Free	100 µg	290.00 USD
ALX-804-323F-T100	FITC	100 tests	390.00 USD
ALX-804-323TD-T100	ATTO 488	100 tests	395.00 USD
ALX-804-323TS-T100	ATTO 647N	100 tests	395.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TL2.1
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	TL2.1: Liquid. In PBS containing 0.02% sodium azide. TL2.1PF: Liquid. In PBS. TL2.1-ATTO 488: Liquid. In PBS containing 0.02% sodium azide. TL2.1-ATTO 647N: Liquid. In PBS containing 0.02% sodium azide. TL2.1-FITC: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	CHO cells stably transfected with human TLR2 (Toll-like receptor 2).
SPECIFICITY:	Recognizes human TLR2. Does not cross-react with human TLR1 or TLR4.
APPLICATION:	TL2.1: ELISA Flow Cytometry [2, 4]: Incubate with 37°C (1:10-1:100) and then on ice with GAM-FITC. Immunohistochemistry Immunoprecipitation TL2.1 (Preservative Free): ELISA Flow Cytometry [2, 4]: Incubate with 37°C (1:10-1:100) and then on ice with GAM-FITC. Immunohistochemistry Immunoprecipitation Functional Application (blocking) [1, 5-7]: Use preservative free formulation. TL2.1-ATTO 488: Flow Cytometry (1:100) TL2.1-ATTO 647N: Flow Cytometry (1:100) TL2.1-FITC: Flow Cytometry [2, 4]
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.

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Product Description

New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
Licenced product covered by US Patent 7,071,310. Sold with permission of Leiv Eiriksson Nyskaping AS.

Product Specific Literature References

[1] Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products: E. Lien, et al.; J. Biol. Chem. 274, 33419 (1999) Abstract; Full Text
[2] Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide: T.H. Flo, et al.; J. Immunol. 164, 2064 (2000) Abstract; Full Text
[3] Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation: E. Faure, et al.; J. Immunol. 166, 2018 (2001) Abstract; Full Text
[4] Differential expression of Toll-like receptor 2 in human cells: T.H. Flo, et al.; J. Leukoc. Biol. 69, 474 (2001) Abstract
[5] A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway: E. Lien, et al.; J. Biol. Chem. 276, 1873 (2001) Abstract; Full Text
[6] Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2: S. Sugawara, et al.; Infect. Immun. 69, 4951 (2001) Abstract
[7] Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae: J.E. Wang, et al.; Infect. Immun. 69, 2402 (2001) Abstract; Full Text
[8] Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses: I. Sabroe, et al.; J. Immunol. 168, 4701 (2002) Abstract
[9] Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling: H.K. Lee, et al.; J. Immunol. 168, 4012 (2002) Abstract; Full Text
[10] A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization: D. van der Kleij, et al.; J. Biol. Chem. 277, 48122 (2002) Abstract; Full Text
[11] Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells: A.E. Medvedev, et al.; J. Immunol. 169, 5209 (2002) Abstract; Full Text
[12] Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction: E. Latz, et al.; J. Biol. Chem. 277, 47834 (2002) Abstract; Full Text
[13] Haemophilus influenzae porin induces Toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages: M. Galdiero, et al.; Infect. Immun. 72, 1204 (2004) Abstract; Full Text
[14] Divergent trophoblast responses to bacterial products mediated by TLRs: V.M. Abrahams, et al.; J. Immunol. 173, 4286 (2004) Abstract
[15] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION	TL2.1-FITC: 1 test means: 1µl of a 0.1mg/ml stock solution were used to stain 200’000 cells in a sample volume of 50µl.
MANUFACTURER	Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-324

Revised 09-May-07

Monoclonal Antibody to Toll-like Receptor 2 (human) (TL2.3)
SYNONYMS	anti-TLR2 (human) MAb (TL2.3) anti-Toll/Interleukin-1 Receptor-like Gene 4 (human) MAb (TL2.3) anti-TIL4 (human) MAb (TL2.3) anti-CD282 (human) MAb (TL2.3)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-324-C050		50 µg	230.00 USD
ALX-804-324PF-C100	Preservative Free	100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TL2.3
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml
FORMULATION:	TL2.3: Liquid. In PBS containing 0.02% sodium azide. TL2.3 (preservative free): Liquid. In PBS.
IMMUNOGEN:	CHO cells stably transfected with human TLR2 (Toll-like receptor 2).
SPECIFICITY:	Recognizes human TLR2. Does not cross-react with human TLR1 or TLR4.
APPLICATION:	ELISA Immunocytochemistry Immunohistochemistry (frozen sections)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

Product Description

Licenced product covered by US Patent 7,071,310. Sold with permission of Leiv Eiriksson Nyskaping AS.

Product Specific Literature References

Differential expression of Toll-like receptor 2 in human cells: T.H. Flo, et al.; J. Leukoc. Biol. 69, 474 (2001) Abstract
The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus: D. Iwaki, et al.; J. Biol. Chem. 277, 24315 (2002) Abstract; Full Text
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target: K.W. Schjetne, et al.; J. Immunol. 171, 32 (2003) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-362

Revised 18-Dec-08

Monoclonal Antibody to Toll-like Receptor 3 (40C1285.6)
SYNONYMS	anti-TLR3 MAb (40C1285.6) anti-CD283 MAb (40C1285.6)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-362-C100		100 µg	293.00 USD
ALX-804-362B-C100	Biotin	100 µg	319.00 USD
ALX-804-362F-C100	FITC	100 µg	358.00 USD
ALX-804-362R-C100	R-PE	100 µg	397.00 USD

Product Specification

SPECIES CROSSREACTIVITY:

Human

Dog