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Items 22 of 22
ALX-350-019 Revised 16-Oct-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C16H24O4
MW: 280.4
CAS NUMBER: 20350-15-6
MERCK INDEX: 14: 1369
SOURCE/HOST: Isolated from Eupenicillium brefeldianum.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol, acetone or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specific Literature References
Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract
Further Categories Containing This Product:
Golgi Apparatus • Collagen / Related Products • Antitumor Agents (Apoptosis Inducers) • Autophagy Other Products • Na+ Channels • Antibiotics - Antiviral / Anti-HIV • ADP Ribosylation Factor [ARF] / Related Products • Antitumor Antibiotics • Antibiotics - Antifungal
 
 
ALX-350-052 Revised 17-Nov-08
Dihydrocapsaicin
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SYNONYMS 8-Methyl-N-vanillylnonanamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-350-052-M010   10 mg 28.00 USD Add To Cart
ALX-350-052-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C18H29NO3
MW: 307.4
CAS NUMBER: 19408-84-5
RTECS: RA5998000
SOURCE/HOST: Isolated from Capsicum fruit.
PURITY: ≥85%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT. POTENT NEUROTOXIN.

Product Description
Dihydro-analog and congener of capsaicin (Prod. No. ALX-550-066) in chili peppers (Capsicum). Like capsaicin it is irritant. Dihydrocapsaicin accounts for about 22% of the total capsaicinoids mixture and has about the same pungency as capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic.
Product Specific Literature References
The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells: T. Lawson & P. Gannett; Cancer Lett. 48, 109 (1989) Abstract
Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep: R. Ramirez-Romero, et al.; Regul. Pept. 91, 97 (2000) Abstract
Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II): S. Singh, et al.; Cancer Lett. 169, 139 (2001) Abstract
Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry: A. Garces-Claver, et al.; J. Agric. Food Chem. 54, 9303 (2006) Abstract
Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids: K.D. Ahuja, et al.; J. Agric. Food Chem. 54, 6436 (2006) Abstract
General Literature References
Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin,induces autophagy in human cancer cells in a catalase-regulated manner: S.H. Oh, et al.; Autophagy 4, 1009 (2008) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Autophagy Other Products • Alkaloids • Natural Products for Neurological Research
 
 
ALX-550-084 Revised 13-Dec-04
Carbamazepine
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SYNONYMS 5H-Dibenz[b,f]azepine-5-carboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-084-G001   1 g 10.00 USD Add To Cart
ALX-550-084-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C15H12N2O
MW: 236.3
CAS NUMBER: 298-46-4
MERCK INDEX: 14: 1781
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Anticonvulsant and analgesic.
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • Autophagy Other Products
 
 
ALX-270-078 Revised 16-Jun-06
L-690,330
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SYNONYMS [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
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ALX-270-078-M001   1 mg 30.00 USD Add To Cart
ALX-270-078-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C8H12O8P2
MW: 298.1
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent inositol monophosphatase inhibitor, resistant to hydrolysis.
Product Specific Literature References
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330: J.R. Atack, et al.; J. Neurochem. 60, 652 (1993) Abstract
Further Categories Containing This Product:
Autophagy Other Products
 
 
ALX-804-367 Revised 04-Nov-08
Monoclonal Antibody to Bif-1 (human) (30A882.1.1)
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SYNONYMS anti-Bax Interacting Factor-1 (human) MAb (30A882.1.1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
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ALX-804-367-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 30A882.1.1
ISOTYPE: Mouse IgG
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human Bif-1 (Bax interacting factor-1).
SPECIFICITY: Recognizes human Bif-1.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

Stable for 6 months when stored at +4°C.
Product Images
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Product Specific Literature References
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text
Endophilin B1 is required for the maintenance of mitochondrial morphology: M. Karbowski, et al.; J. Cell Biol. 166, 1027 (2004) Abstract
General Literature References
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis: Y. Takahashi, et al.; Nat. Cell Biol. 9, 1142 (2007) Abstract
Further Categories Containing This Product:
Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-804-196 Revised 27-Aug-08
Monoclonal Antibody to Ceramide (MID 15B4)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-804-196-T050   50 tests 315.00 USD Add To Cart
Product Specification
CLONE: MID 15B4
ISOTYPE: Mouse IgM
SOURCE/HOST: Purified from ascites by gel filtration on sephacryl S-300.
QUANTITY: 1ml (50 tests). Suggested amount: 20µl/test.
CONCENTRATION: 200µg/ml
PURITY: ≥95%
FORMULATION: Liquid. In PBS, pH 7.2, containing 0.5M sodium chloride, 0.1% BSA and 0.09% sodium azide.
IMMUNOGEN: Ceramide (sphingosine-[trans-D-erythro-2-amino-4-octadecene-1,3-diol]) conjugated to BSA.
SPECIFICITY: Recognizes C16- and C24-ceramide, dihydroceramide, sphingomyelin and phosphatidylcholine in highly artificial lipid overlay test systems. Under more physiological in vitro and in vivo conditions highly specific for ceramide and does not cross-react with sphingomyelin, cholesterol or other phospholipids (see lit. ref. [1], [2], [3]).
APPLICATION: ELISA (1:10)
Flow Cytometry (see [2])
Immunocytochemistry (see [11,12])
Immunohistochemistry (1:10)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
[1] Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies: L.A. Cowart, et al.; J. Lipid Res. 43, 2042 (2002) Abstract; Full Text
[2] CD95 Signaling Via Ceramide-rich Membrane Rafts: H. Grassme, et al.; J. Biol. Chem. 276, 20589 (2002) Abstract; Full Text
[3] Ceramide-Rich Membrane Rafts Mediate CD40 Clustering: H. Grassme, et al.; J. Immunol. 168, 298 (2002) Abstract; Full Text
[4] Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms: J. Bock, et al.; BBRC 305, 890 (2003) Abstract
[5] Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts: H. Grassme, et al.; Nat. Med. 9, 322 (2003) Abstract
[6] Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide: E. Bieberich, et al.; J. Cell Biol. 162, 469 (2003) Abstract; Full Text
[7] PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide: R. Goggel, et al.; Nat. Med 10, 155 (2004) Abstract
[8] Study on ceramide expression and DNA content in patients with healthy mucosa, leukoplakia, and carcinoma of the larynx: F.L. Chi, et al.; Arch. Otolaryngol. Head Neck Surg. 130, 307 (2004) Abstract
[9] Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes: K.S. Lang, et al.; Cell Death Differ. 11, 231 (2004) Abstract
[10] Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl: K.S. Lang, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 286, F1046 (2004) Abstract
[11] Clustering of CD40 ligand is required to form a functional contact with CD40: H. Grassme, et al.; J. Biol. Chem. 277, 30289 (2002) Abstract
[12] Caspase-dependent and -independent activation of acid sphingomyelinase signaling: J.A. Rotolo, et al.; J. Biol. Chem. 280, 26425 (2005) Abstract; Full Text
Further Categories Containing This Product:
Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-804-239 Revised 05-Jun-07
Monoclonal Antibody to STAT6 (human) (8C12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
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ALX-804-239-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 8C12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to aa 630-650 of human STAT6.
SPECIFICITY: Recognizes human STAT6. Detects a band of ~97kDa by Western blot.
APPLICATION: Immunohistochemistry
Western Blot (1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Upon reconstitution, prepare aliquots and freeze in liquid nitrogen; reconstituted antibody can be stored frozen at -80°C up to 1 year. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-030).
Further Categories Containing This Product:
Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-804-272 Revised 13-Jun-08
Monoclonal Antibody to STAT6 (phosphorylated) (pTyr641) (16E12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
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ALX-804-272-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 16E12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of human STAT6 phophorylated at Tyr641.
SPECIFICITY: Recognizes the GRGpYVPA motif of human, mouse (weak) and rat (weak) activated STAT6 phosphorylated at Tyr641. Does not cross-react with the non-phosphorylated form of STAT6 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION: Immunohistochemistry
Western Blot (1HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-018).
Product Specific Literature References
IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos: A. Lorentz, et al.; J. Immunol. 174, 6751 (2005) Abstract; Full Text
General Information
STATs (signal transducing activators of transcription) are mediators involved in cytokine signalling. In response to a specific cytokine signal, STATs move to the nucleus and induce transcription. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinases (JAKs). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it participates in transcriptional control.
Further Categories Containing This Product:
Phospho-specific Antibodies • Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-804-248 Revised 01-Oct-07
Monoclonal Antibody to TRAF2 (human) (33A1293)
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SYNONYMS anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (human) (33A1293)
PRODUCT LINE Inflammation
PRODUCT CATEGORY TRAFs / Related Products
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ALX-804-248-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 33A1293
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2) (aa 205-222).
SPECIFICITY: Recognizes human TRAF2. Detects a band of ~57kDa by Western blot.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Product Specific Literature References
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors: F.I. Hawari, et al.; PNAS 101, 1297 (2004) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-803-051 Revised 07-Mar-06
Monoclonal Antibody to Transglutaminase 2 (KB1/5)
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SYNONYMS anti-Tissue Transglutaminase MAb (KB1/5)
anti-TGase 2 MAb (KB1/5)
anti-Protein-glutamine γ-glutamyltransferase MAb (KB1/5)