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PP2B [Calcineurin] / Related Products
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Items 11 of 11
ALX-430-031 Revised 11-Jan-07
Allethrin
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SYNONYMS (R,S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,S)-cis,trans-chrysanthemate
Allylcinerin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-031-M010   10 mg 30.00 USD Add To Cart
ALX-430-031-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 584-79-2
MERCK INDEX: 14: 260
RTECS: GZ1925000
PURITY: ≥95% (HPLC)
APPEARANCE: Clear or whitish film.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalis.
HAZARD: HARMFUL.

Product Description
Type I pyrethroid, useful as a very weakly active "negative" control for inhibition of calcineurin (protein phosphatase 2B) by type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-151-019 Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
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SYNONYMS PKA Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-019-MC05   0.5 mg 95.00 USD Add To Cart
ALX-151-019-M001   1 mg 165.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA: C92H150N28O29
MW: 2112.4
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity: D.K. Blumenthal, et al.; J. Biol. Chem. 261, 8140 (1986) Abstract; Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate: A. Enz, et al.; Anal. Biochem. 216, 147 (1994) Abstract
Further Categories Containing This Product:
Peptides • PP2B [Calcineurin] / Related Products
 
 
ALX-380-005 Revised 03-Apr-08
Ascomycin
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SYNONYMS Immunomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-380-005-M001   1 mg 125.00 USD Add To Cart
ALX-380-005-M005   5 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C43H69NO12
MW: 792.0
CAS NUMBER: 11011-38-4
RTECS: CI75700000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Ethyl analog of FK506 (Prod. No. ALX-380-008) with similar immunosuppressant properties. Inhibits calcineurin phosphatase.
Product Specific Literature References
Ascomycin, an antifungal antibiotic: T. Arai, et al.; J. Antibiot. (Tokyo) 15, 23 (1962) Abstract
NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein: A.M. Petros, et al.; J. Med. Chem. 35, 2467 (1992) Abstract
Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues: M. Kawai, et al.; FEBS Lett. 316, 107 (1993) Abstract
Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins): A. Shafiee, et al.; J. Antibiot. (Tokyo) 46, 1397 (1993) Abstract
Further Categories Containing This Product:
Antibiotics - Other Signal Transduction Pathway Modulators • PP2B [Calcineurin] / Related Products
 
 
ALX-430-032 Revised 24-Feb-05
Bioallethrin
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SYNONYMS D-trans-Allethrin
(S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,3R)-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropancarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-032-M025   25 mg 90.00 USD Add To Cart
ALX-430-032-M100   100 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 22431-63-6
PURITY: ≥97%
SOLUBILITY: Soluble in hot water, diluted acids or alkaline solutions; hardly soluble in cold water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalies.
HAZARD: HARMFUL.

Product Description
Although bioallethrin is a type I pyrethroid, its effects on calcineurin (protein phosphatase 2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-202-034 Revised 13-Dec-04
Calcineurin (bovine brain)
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SYNONYMS Calmodulin Binding Protein (bovine brain)
Protein Phosphatase 2B (bovine brain)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-202-034-U100   100 U 590.00 USD Add To Cart
Product Specification
CAS NUMBER: 9025-75-6
EC: 3.1.3.16
MERCK INDEX: 14: 1640
SOURCE/HOST: Isolated from bovine brain.
FORMULATION: Lyophilized powder containing ~1% protein (Lowry) and 0.5% EGTA, buffer salts and stabilizers.
SPECIFIC ACTIVITY: ~2'500-5'000U/mg protein. One unit causes a 50% inhibition of the activated phosphodiesterase activity when assayed with 2 units of activator and 0.1mM Ca2+ in an enzyme coupled system at 30°C, pH 7.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Natural Proteins • Enzymes • Nitric Oxide Pathway Other Products
 
 
ALX-430-044 Revised 29-Feb-08
Cypermethrin
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SYNONYMS Alphamethrine
(R,S)-α-Cyano-(3-phenoxyphenyl)methyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
Pestanal
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-044-M010   10 mg 40.00 USD Add To Cart
ALX-430-044-M025   25 mg 80.00 USD Add To Cart
ALX-430-044-M100   100 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C22H19Cl2NO3
MW: 416.3
CAS NUMBER: 52315-07-8
MERCK INDEX: 14: 2767
RTECS: GZ1250000
PURITY: ≥95% (HPLC)
FORMULATION: Clear or whitish film adhered to inside of vial.
SOLUBILITY: Soluble in methanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.
IDENTITY: Determined by 1H-NMR.

Product Description
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B).
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Inhibition of phosphatase 2B prevents expression of hippocampal long- term potentiation: J.H. Wang & A. Stelzer; Neuroreport 5, 2377 (1994) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-430-045 Revised 24-Feb-05
Deltamethrin
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SYNONYMS (S)-α-Cyano-(3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-430-045-M010   10 mg 45.00 USD Add To Cart
ALX-430-045-M025   25 mg 96.00 USD Add To Cart
Product Specification
FORMULA: C22H19Br2NO3
MW: 505.2
CAS NUMBER: 52918-63-5
MERCK INDEX: 14: 2883
PURITY: ≥98%
APPEARANCE: Whitish film.
SOLUBILITY: Soluble in DMSO, ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Type II pyrethrin, potent inhibitor of calcineurin (protein phosphatase 2B). Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids: E. Enan & F. Matsumura; Biochem. Pharmacol. 45, 703 (1993) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-550-267 Revised 05-Feb-07
Fenvalerate
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SYNONYMS α-Cyano-3-phenoxybenzyl α-(4-chlorophenyl)isovalerate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
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ALX-550-267-M025   25 mg 43.00 USD Add To Cart
ALX-550-267-M100   100 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C25H22ClNO3
MW: 419.9
CAS NUMBER: 51630-58-1
MERCK INDEX: 14: 4010
RTECS: CY1576350
PURITY: ≥98% (mixture of diastereoisomers)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B). May also have varied effects on ion channels. Induces depolarization by keeping Na+ channels in an open state.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Effect of fenvalerate, a pyrethroid insecticide on membrane fluidity: S.N. Sarkar, et al.; Biochim. Biophys. Acta 1147, 137 (1993) Abstract
Immobilization of sodium channel gating charge in crayfish giant axons by the insecticide fenvalerate: V.L. Salgado & T. Narahashi; Mol. Pharmacol. 43, 626 (1993) Abstract
Further Categories Containing This Product:
Pyrethroids • Na+ Channels
 
 
ALX-380-008 Revised 05-Apr-08
FK506
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SYNONYMS Tacrolimus
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-008-M001   1 mg 30.00 USD Add To Cart
ALX-380-008-M005   5 mg 60.00 USD Add To Cart
ALX-380-008-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C44H69NO12 . H2O
MW: 804.0 . 18.0
CAS NUMBER: 104987-11-3
MERCK INDEX: 14: 9025
RTECS: KD4200000
PURITY: ≥98%
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol, ethyl acetate or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL. MAY BE CARCINOGENIC. IRRITANT.

Product Description
Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK506 binding protein and to inhibit the Ca2+-dependent phosphatase and protein phosphatase 2B (PP2B; calcineurin). Activates NF-κB through phosphorylation and degradation of IκBα.
Product Specific Literature References
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics: T. Kino, et al.; J. Antibiot. (Tokyo) 40, 1249 (1987) Abstract
Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology: B.E. Bierer, et al.; Curr. Opin. Immunol. 5, 763 (1993) Abstract
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression: J. Kunz and M.N. Hall; TIBS 18, 334 (1993) Abstract
Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites: Y. Zhang, et al.; J. Biol. Chem. 274, 34657 (1999) Abstract; Full Text
FK506, an immunosuppressant targeting calcineurin function: F.J. Dumont; Curr. Med. Chem. 7, 731 (2000) Abstract
FK506 and its analogs - therapeutic potential for neurological disorders: A. Klettner and T. Herdegen; Curr. Drug Targets CNS Neurol. Disord. 2, 153 (2003), Review Abstract
A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis: S. Miyata, et al.; Inflamm. Res. 54, 1 (2005), Review Abstract
Further Categories Containing This Product:
Antibiotics - NF-kB Inhibitors • NF-kB Pathway Inhibitors • PP2B [Calcineurin] / Related Products
 
 
ALX-350-113 Revised 28-May-08
Gossypol
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SYNONYMS 2,2’-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-
methylnaphthalene]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
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ALX-350-113-M100   100 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C30H30O8
MW: 518.6
CAS NUMBER: 303-45-7
MERCK INDEX: 14: 4528
RTECS: DU3100000
SOURCE/HOST: Isolated from Gossypium genus, Malvaceae.
PURITY: ≥90%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in acetone or DMSO; sparingly soluble in 100% ethanol (2mg/ml) or methanol (2mg/ml). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: