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Bone Metabolism
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ALX-460-026 Revised 25-Mar-08
Vitamin D3
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SYNONYMS Cholecalciferol
Colecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-026-G001   1 g 23.00 USD Add To Cart
ALX-460-026-G005   5 g 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O
MW: 384.7
CAS NUMBER: 67-97-0
MERCK INDEX: 14: 10019
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Oxidized and inactivated by moisture within a few days.
HANDLING: Keep under inert gas. Protect from light and moisture.

Further Categories Containing This Product:
Vitamins
 
 
ALX-460-032 Revised 18-Dec-07
Calcitriol
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SYNONYMS Vitamin D3, 1α,25-Dihydroxy-
1α,25-Dihydroxyvitamin D3
1,25(OH)2D3
1α,25-Dihydroxycholecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-032-C100   100 µg 150.00 USD Add To Cart
ALX-460-032-M001   1 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C27H44O3
MW: 416.7
CAS NUMBER: 32222-06-3
MERCK INDEX: 14: 1644
RTECS: FZ4645000
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Slightly soluble in methanol, 100% ethanol, ethyl acetate or tetrahydrofuran. 
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Osteotropic hormone that up-regulates RANKL level and down-regulates OPG level. Biologically active form of vitamin D3 in intestinal calcium transport and bone calcium resorption.
Product Specific Literature References
A rapidly acting metabolite of vitamin D3: Haussler, et al.; PNAS 68, 177 (1971) Abstract
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture: Raisz, et al.; Science 175, 768 (1972) Abstract
Further Categories Containing This Product:
Vitamins
 
 
ALX-460-036 Revised 17-Jan-05
Alfacalcidol
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SYNONYMS Hydroxyvitamin D3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-036-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O2
MW: 400.6
CAS NUMBER: 41294-56-8
RTECS: VS2851000
PURITY: ≥97%
APPEARANCE: White to off white crystals.
SOLUBILITY: Soluble in ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No. ALX-460-032) in vivo. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
 
 
ALX-522-007 Revised 30-Jul-07
Osteoprotegerin (human):Fc (human) (recombinant)
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SYNONYMS OPG (human):Fc (human) (recombinant)
TNFRSF 11B (human):Fc (human) (recombinant)
Osteoclastogenesis Inhibitory Factor (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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ALX-522-007-C050   50 µg 340.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human OPG (osteoprotegerin) (aa 22-202) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse RANKL and TRAIL.
BIOLOGICAL ACTIVITY: Inhibits rhsTRAIL-mediated apoptosis at a concentration range of 5-20µg/ml, as well as rhsRANKL-induced osteoclastogenesis and stimulation of dendritic cells. Concentrations of rhOPG:Fc required to inhibit may vary depending on the cell type studied and on the concentration of rhsTRAIL used to kill the cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Receptor activator of NF-κB and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis: P. Collin-Osdoby, et al.; J. Biol. Chem. 276, 20659 (2001) Abstract; Full Text
A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95: C. Assohou-Luty, et al.; J. Mol. Med. 84, 785 (2006) Abstract
General Information
Osteoprotegerin (OPG) is a secreted tumor necrosis factor receptor homologue that inhibits osteoclastogenesis and increases bone density in vivo. OPG contains 4 cysteine-rich repeats and 2 ‘death domains’ (DD). OPG binds to RANKL (TRANCE) and with a similar affinity to TRAIL.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O00300: Osteoprotegrin (human) (precursor)
AfCS Signalling Gateway link A002819: Osteoprotegrin (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-012 Revised 28-Apr-06
RANKL, Soluble (human) (recombinant)
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SYNONYMS ODF, Soluble (human) (recombinant)
OPGL, Soluble (human) (recombinant)
TRANCE, Soluble (human) (recombinant)
TNFSF 11, Soluble (human) (recombinant)
CD254, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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ALX-522-012-C010   10 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~18kDa (non-glycosylated), ~28kDa (glycosylated) (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human RANKL (aa 151-316) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
SOLUBILITY: Soluble in water.
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human and mouse RANK.
BIOLOGICAL ACTIVITY: Supports the survival of dendritic cells and osteoclasts.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Receptor activator of NF-κB and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis: P. Collin-Osdoby, et al.; J. Biol. Chem. 276, 20659 (2001) Abstract; Full Text
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001) Abstract; Full Text
Suppression of IL-12 Production by Soluble CD40 Ligand: Evidence for Involvement of the p44/42 Mitogen-Activated Protein Kinase Pathway: M. Wittmann, et al.; J. Immunol. 168, 3793 (2002) Abstract
Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-kappaB Mutations or Activation of the CD30, CD40, and RANK Receptors: B. Zheng, et al.; Clin. Cancer Res. 10, 3207 (2004) Abstract
A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response: D. Seshasayee, et al.; J. Biol. Chem. 279, 30202 (2004) Abstract
General Information
RANK ligand (RANKL), also called TRANCE, OPGL and ODF, is a member of the TNF family that is expressed in activated T cells, lymph nodes and in stromal cell lines. RANKL (TRANCE) interacts with its receptor RANK expressed on mature dendritic cells (DC) and mature osteoclasts, leading to the inhibition of apoptosis, probably through the upregulation of bcl-x. RANKL is, therefore, a useful tool for enhancing DC and osteoclast survival and activity. Osteoprotegerin (OPG, see Prod. No. ALX-522-007) is a potent inhibitor of RANKL.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link O014788: RANKL (human)
AfCS Signalling Gateway link A002020: RANKL (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function: D.M. Anderson, et al.; Nature 390, 175 (1997) Abstract
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor: B.R. Wong, et al.; J. Exp. Med. 186, 2075 (1997) Abstract
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation: D.L. Lacey, et al.; Cell 93, 165 (1998) Abstract
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL: H. Yasuda, et al.; PNAS 95, 3597 (1998) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-039 Revised 24-Mar-05
RANK (human):Fc (human) (recombinant)
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SYNONYMS TRANCE-R (human):Fc (human) (recombinant)
ODFR (human):Fc (human) (recombinant)
TNFRSF 11A (human):Fc (human) (recombinant)
CD265 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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ALX-522-039-C050   50 µg 360.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~55kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human RANK (aa 29-213) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human and mouse RANKL.
BIOLOGICAL ACTIVITY: Inhibits human rhsRANKL-induced survival of dendritic cells and osteoclasts.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Once reconstituted, it is recommended to prepare appropriate aliquots and to store them at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
The receptor activator of NF-κB (RANK) is a member of the tumor necrosis factor receptor (TNF-R) family. RANK is a type I transmembrane receptor. It is 616 aa long and contains 4 cysteine-rich motifs in its extracellular domain, while its long cytoplasmic domain spans 383 aa. RANK is mainly expressed on dendritic cells. After binding its ligand RANKL, RANK interacts with TNF receptor-associated factor 1 (TRAF1), TRAF2, TRAF3, TRAF5 and TRAF6 which mediate activation of nuclear factor NF-κB and JNK. RANK-RANKL interactions promote survival of dendritic cells as well as differentiation in osteoclasts.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y6Q6: RANK (human) (precursor)
AfCS Signalling Gateway link A002019: RANK (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-103 Revised 19-Aug-08
RGMA, Soluble (human) (recombinant)
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SYNONYMS Repulsive Guidance Molecule A, Soluble (human) (recombinant)
RGM Domain Family Member A, Soluble (human) (recombinant)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Growth, Survival and Development of Neurons Other Products
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ALX-522-103-2010   2x10 µg 240.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human RGMA (aa 48-422) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
The Neogenin Intracellular Domain Regulates Gene Transcription via Nuclear Translocation: D. Goldschneider, et al.; Mol. Cell. Biol. 28, 4068 (2008) Abstract
General Information
The RGMA is an GPI-anchored protein involved in the axon guidance and is predominantly expressed in the developing and adult central nervous system in mouse. RGMA inhibits mammalian CNS neurite outgrowth. The protein acts as co-receptor of the bone morphogenetic protein. The mature RGMA protein is proteolytically processed and is glycosylated.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q96B86: Repulsive Guidance Molecule A (human) (Precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor: J.L. Babitt, et al.; J. Biol. Chem. 280, 29820 (2005) Abstract; Full Text
RGMa inhibition promotes axonal growth and recovery after spinal cord injury: K. Hata, et al.; J. Cell Biol. 173, 47 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Dependence Receptors Other Products • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
 
 
ALX-522-104 Revised 19-Aug-08
RGMC, Soluble (human) (recombinant)
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SYNONYMS Repulsive Guidance Molecule C, Soluble (human) (recombinant)
Hemojuvelin, Soluble (human) (recombinant)
Hemochromatosis Type 2 Protein, Soluble (human) (recombinant)
HFE2, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Dependence Receptors Other Products
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ALX-522-104-C010   10 µg 290.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human RGMC (aa 36-398) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6ZVN8: Repulsive Guidance Molecule C (human) (Precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
RGM and its receptor neogenin regulate neuronal survival: E. Matsunaga, et al.; Nat. Cell Biol. 6, 749 (2004) Abstract
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload: V. Niederkofler, et al.; J. Clin. Invest. 115, 2180 (2005) Abstract
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression: J.L. Babitt, et al.; Nat. Genet. 38, 531 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Growth, Survival and Development of Neurons Other Products
 
 
ALX-522-131 Revised 27-Mar-08
Fc (human):RANKL, Soluble (mouse) (rec.)
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SYNONYMS Fc (human):ODF, Soluble (mouse) (recombinant)
Fc (human):OPGL, Soluble (mouse) (recombinant)
Fc (human):TRANCE, Soluble (mouse) (recombinant)
Fc (human):TNFSF 11, Soluble (mouse) (recombinant)
Fc (human):CD254, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
Ordering Information
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ALX-522-131-C010   10 µg 390.00 USD Add To Cart
Product Specification
MW: ~55kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse RANKL (aa 157-316) is fused to the Fc portion of human IgG1.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to mouse RANK.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: