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T Cell Signalling
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ALX-522-057 Revised 01-Oct-08
IL-1 Receptor Type I (human):Fc (human) (recombinant)
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SYNONYMS IL-1RI (human):Fc (human) (recombinant)
Interleukin-1 Receptor Type I (human):Fc (human) (recombinant)
CD121a (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-057-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~83kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds to human IL-1 (interleukin-1).
BIOLOGICAL ACTIVITY: Blocks IL-1 activity.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cytokine receptors and signal transduction: A. Miyajima, et al.; Annu. Rev. Immunol. 10, 295 (1992) Abstract
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily: J.E. Sims, et al.; Science 241, 585 (1988) Abstract
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense: L.A. O'Neill; Sci. STKE 2000, RE1 (2000) Abstract
IL-1 and IL-18 receptors, and their extended family: J.E. Sims, et al.; Curr. Opin. Immunol. 14, 117 (2002) Abstract
Related Products
Further Categories Containing This Product:
CD Proteins • Interleukin-1 [IL-1] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-159-001 Revised 01-Mar-06
IL-2 Receptor Fragment (human)
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SYNONYMS Interleukin-2 Receptor Fragment (human)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-159-001-M001   1 mg 80.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile-OH
FORMULA: C59H113N29O16
MW: 1484.7
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC). The peptide is derived from the cytoplasmic C-terminus of the human interleukin-2 receptor.
Product Specific Literature References
Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain: B. Gallis, et al.; J. Biol. Chem. 261, 5075 (1986) Abstract; Full Text
Further Categories Containing This Product:
CD25 [IL-2Ralpha] / Related Products • PKC Substrates • Peptides
 
 
APO-54N-025 Revised 05-Dec-08
IL-33, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS Interleukin-33, Soluble (human) Detection Set [For ELISA Application]
NF-HEV, Soluble (human) Detection Set [For ELISA Application]
IL-1F11, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-025-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 5pg/ml (range 0 to 500pg/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble human IL-33 from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse IL-33.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. For long term storage keep the standard (STD) at -20°C.
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General Information
Interleukin-1 (IL-1) family members, such as IL-1α/β and IL-18 play important roles in host defense, immune regulation, neuronal injury and inflammation [1, 2]. Recently, a new member of this family, IL-33, also named Nuclear Factor from High Endothelial Venules (NF-HEV) [3], has been reported to be the specific ligand for ST2 [4], an orphan receptor of the IL-1 receptor family [5]. Structurally, IL-33 is closest to IL-18, rather than IL-1β. The human IL-33 is expressed with a prodomain (aa 1-111) that is cleaved by caspase-1 to produce a 18kDa mature protein (112-270) [6]. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK athways. IL-33 is synthesized in response to cytokines such as IL-1β (but also TNFα) and plays an important role in TH2-associated immunology, by triggering an increase secretion of IL-5 and IL-13 from polarized TH2 cells. Overexpression of IL-33 in mice leads to severe pathological changes in mucosal organs.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Differences in signaling pathways by IL-1beta and IL-18: J.K. Lee, et al. ; Proc. Natl. Acad. Sci. 101, 8815 (2004) Abstract
[2] Interleukin-1 and neuronal injury: S.M. Allan, et al.; Nat. Rev. Immunol. 5, 629 (2005) Abstract
[3] Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules: E.S. Baekkevold, et al. ; Am. J. Pathol. 163, 69 (2003) Abstract
[4] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
[5] ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance: E.K. Brint, et al. ; Nat. Immunol. 5, 373 (2005) Abstract
[6] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases: F. Martinon & J. Tschopp; Cell 117, 561 (2004) Abstract
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • ELISA Sets
 
 
ALX-201-363 Revised 01-Oct-08
IL-33 (human) (recombinant)
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SYNONYMS Interleukin-33 (human) (recombinant)
NF-HEV (human) (recombinant)
IL-1F11 (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-363-C010   10 µg 295.00 USD Add To Cart
ALX-201-363-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Recombinant human IL-33 (aa 112-270) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human) (recombinant)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-098 Revised 04-Nov-08
IL-33 (human) (recombinant)
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SYNONYMS Interleukin-33 (human) (recombinant)
NF-HEV (human) (recombinant)
IL-1F11 (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-098-C010   10 µg 190.00 USD Add To Cart
ALX-522-098-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~18kDa
SOURCE/HOST: Produced in E. coli. Untagged human IL-33 (aa 112-270).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates human ST2-dependent NF-κB pathway. Does not activate mouse ST2-dependent NF-κB.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; PNAS 104, 282 (2007) Abstract
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33: T. Pecaric-Petkovic et al.; Blood Epub ahead of print, (2008) Abstract
General Information
IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
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Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-350 Revised 01-Oct-08
IL-33 (human) (recombinant) (His)
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SYNONYMS Interleukin-33 (human) (recombinant) (His)
NF-HEV (human) (recombinant) (His)
IL-1F11 (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-201-350-C010   10 µg 295.00 USD Add To Cart
ALX-201-350-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Recombinant human IL-33 (aa 112-270) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing
150mM sodium chloride.
ENDOTOXIN CONTENT: <1.0EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human) (recombinant)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-101 Revised 01-Oct-08
IL-33 (mouse) (recombinant)
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SYNONYMS Interleukin-33 (mouse) (recombinant)
NF-HEV (mouse) (recombinant)
IL-1F11 (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-101-C010   10 µg 190.00 USD Add To Cart
ALX-522-101-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~18kDa
SOURCE/HOST: Produced in E. coli. Untagged mouse IL-33 (aa 109-266).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to mouse and human ST2.
BIOLOGICAL ACTIVITY: Activates mouse and human ST2-dependent NF-κB pathway. Induces IL-6 production in P815 mastocytoma cells and in bone marrow derived mast cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells: S. Ali, et al.; PNAS 104, 18660 (2007) Abstract
General Information
IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The mouse IL-33 protein is expressed with a prodomain (aa 1-108) which is cleaved to produce the 18kDa mature protein (109-266).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ4: Interleukin-33 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
Related Products
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-361 Revised 01-Oct-08
IL-33 (mouse) (recombinant) (His)
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SYNONYMS Interleukin-33 (mouse) (recombinant) (His)
NF-HEV (mouse) (recombinant) (His)
IL-1F11 (mouse) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-361-C010   10 µg 295.00 USD Add To Cart
ALX-201-361-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Recombinant mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing
150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ4: Interleukin-33 (mouse) (recombinant)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-125 Revised 17-Oct-08
IL-33 (rat) (recombinant)
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SYNONYMS Interleukin-33 (rat) (recombinant)
NF-HEV (rat) (recombinant)
IL-1F11 (rat) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-125-C010   10 µg 290.00 USD Add To Cart
Product Specification
MW: ~16kDa
SOURCE/HOST: Produced in E. coli. Untagged rat IL-33 (aa 109-264).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.