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Antibiotics - Antiviral / Anti-HIV
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ALX-350-019 Revised 16-Oct-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C16H24O4
MW: 280.4
CAS NUMBER: 20350-15-6
MERCK INDEX: 14: 1369
SOURCE/HOST: Isolated from Eupenicillium brefeldianum.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol, acetone or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specific Literature References
Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract
Further Categories Containing This Product:
Golgi Apparatus • Collagen / Related Products • Antitumor Agents (Apoptosis Inducers) • Autophagy Other Products • Na+ Channels • Antibiotics - Antiviral / Anti-HIV • ADP Ribosylation Factor [ARF] / Related Products • Antitumor Antibiotics • Antibiotics - Antifungal
 
 
ALX-350-317 Revised 08-Apr-08
Tenuazonic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-317-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C10H15NO3
MW: 197.3
CAS NUMBER: 610-88-8
MERCK INDEX: 14: 9149
RTECS: UY7425000
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Brown oily solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound exhibiting antitumor, antiviral and antibacterial activity. Inhibits protein synthesis by suppression at the ribosome. May act as a mycotoxin.
Product Specific Literature References
Microbial metabolites with insecticidal properties: M. Cole & G.N. Rolinson; Appl. Microbiol. 24, 660 (1972) Abstract
Microbial production of tenuazonic acid analogues: S. Gatenbeck & J. Sierankiewicz; Antimicrob. Agents Chemother. 3, 308 (1973) Abstract
Inhibition of mouse skin tumor promotion by tenuazonic acid: M. Antony, et al.; Cancer Lett. 61, 21 (1991) Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative) • Mycotoxins • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-350-325 Revised 25-Jun-07
Altenusin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-350-325-M001   1 mg 110.00 USD Add To Cart
ALX-350-325-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3
CAS NUMBER: 31186-12-6
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products: T. Rosett, et al.; Biochem. J. 67, 390 (1957) Full Text
Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis: R. Thomas; Biochem. J. 80, 234 (1961) Abstract; Full Text
Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin: R. G. Coombe, et al.; Aus. J. Chem. 23, 2343 (1970)
Host-specific toxins and chemical structures from alternaria species: S. Nishimura, et al.; Ann. Rev. Phytopathol. 21, 87 (1983)
The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts : W. A. Ayer, et al.; Can. J. Chem. 68, 2085 (1990)
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995) Abstract
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999) Abstract
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003) Abstract
Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites : M. Oyama, et al.; Lett. Drug Design Discov. 1, 24 (2004)
New penicillide derivatives isolated from Penicillium simplicissimum: S. I. Komai, et al.; J. Nat. Med. 60, 185 (2006)
HIV-1 integrase inhibitors: 2003-2004 update: R. Dayam, et al.; Med. Res. Rev. 26, 271 (2006) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Tyrosine Kinase Inhibitors • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-350-334 Revised 03-Apr-08
Ascochlorin
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SYNONYMS LL-Z 1272 γ
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-334-MC05   0.5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C23H29ClO4
MW: 404.9
CAS NUMBER: 26166-39-2
RTECS: VH3707560
SOURCE/HOST: Isolated from Acremonium sp. MST-FP1890.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light grey powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antitumor antibiotic. Shows antiviral activity. Inhibitor or matrix metalloproteinase 9 (MMP-9). Reduces the inflammatory response to TNF-α in rat vascular smooth muscle cells. May be useful as an antiatherogenic agent.
Product Specific Literature References
Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I): G. Tamura, et al.; J. Antibiot. (Tokyo) 21, 539 (1968) Abstract
Ascochlorin derivatives as ligands for nuclear hormone receptors: M. Togashi, et al.; J. Med. Chem. 46, 4113 (2003) Abstract
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells: S. Hong, et al.; J. Biol. Chem. 280, 25202 (2005) Abstract; Full Text
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines: K. Sakaguchi, et al.; BBRC 329, 46 (2005) Abstract
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages: J.H. Kang, et al.; J. Cell. Biochem. 102, 506 (2007) Abstract
Further Categories Containing This Product:
MMP Inhibitors • Antibiotics for Cytoskeletal Research • Antibiotics for Inflammation Research • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-380-059 Revised 16-Dec-08
Hygromycin B (liquid)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral / Anti-HIV
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ALX-380-059-UM01   1 MU 94.00 USD Add To Cart
Product Specification
FORMULA: C20H37N3O13
MW: 527.5
CAS NUMBER: 31282-04-9
MERCK INDEX: 14: 4852
RTECS: WK2130000
SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
QUANTITY: 1MU (1 million units); potency ≥385 U/mg.
CONCENTRATION:  ≥450’000U/ml
PURITY: ≥80%
APPEARANCE: Dark brown solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Sterile and ready-to-use antibiotic with high activity. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.
Product Specific Literature References
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958)
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983) Abstract
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995) Abstract
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000) Abstract
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001) Abstract
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Microbiological assay: 350'000-500'000U/ml.
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
ALX-380-067 Revised 08-Apr-08
β-Rubromycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral / Anti-HIV
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ALX-380-067-M001   1 mg 40.00 USD Add To Cart
ALX-380-067-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C27H20O12
MW: 536.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥99%
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of HIV-1 reverse transcriptase (RT). Inhibits human telomerase. Cytostatically active against different tumor cell lines.
Product Specific Literature References
The structure of rubromycin: H. Brockmann, et al.; THL 30, 3525 (1966), (Article in German) Abstract
Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102, 126 (1969) Abstract
Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 1709 (1970) Abstract
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990) Abstract
Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000) Abstract
Structural and Biosynthetic Investigations of the Rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000)
Further Categories Containing This Product:
Antibiotics - Immunomodulators • Antitumor Antibiotics • HIV / AIDS / Related Products • Telomerase / Related Products
 
 
ALX-380-088 Revised 30-Jul-08
Netropsin . dihydrochloride
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SYNONYMS 4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-088-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C18H26N10O3 . 2HCl
MW: 430.5 . 73.0
CAS NUMBER: 63770-20-7 (hydrochloride)
RTECS: DW2973000
SOURCE/HOST: Isolated from Streptomyces netropsis.
PURITY: ≥93% (HPLC)
APPEARANCE: Faint yellow powder.
SOLUBILITY: Soluble in alcohols or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.
Product Specific Literature References
Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951)
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985)
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999) Abstract
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000) Abstract
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review) Abstract
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation / Transcription • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-380-102 Revised 03-Apr-08
Borrelidin
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SYNONYMS 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Treponemycin
U 78548
C2989
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-102-MC05   0.5 mg 160.00 USD Add To Cart
ALX-380-102-M001   1 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C28H43NO6
MW: 489.7
CAS NUMBER: 7184-60-3
RTECS: ED8750000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Antibiotic. Inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). Inhibitor of cyclin-dependent kinase (CDK). Shows angiogenesis inhibiting and antiviral activity.
Product Specific Literature References
Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines: K.J. Kontis and S.M. Arfin; Mol. Cell. Biol. 9, 1832 (1989) Abstract
Genetic analysis of mutations causing borrelidin resistance by overproduction of threonyl-transfer ribonucleic acid synthetase: J. Frohler, et al.; J. Bacteriol. 143, 1135 (1980) Abstract; Full Text
Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line: J.S. Gantt, et al.; PNAS 78, 5367 (1981) Abstract; Full Text
Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase: S.C. Gerken and S.M. Arfin; J. Biol. Chem. 259, 9202 (1984) Abstract; Full Text
Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae: E. Tsuchiya, et al.; J. Antibiot. 54, 84 (2001) Abstract
Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway: E.L. Eastwood and S.E. Schaus; Bioorg. Med. Chem. Lett. 13, 2235 (2003) Abstract
Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989): M. Lumb, et al.; Nature 206, 263 (1965) Abstract
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases: B. Ruan, et al.; J. Biol. Chem. 280, 571 (2005) Abstract; Full Text
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • tRNA / Related Products • Antibiotics - Antiviral / Anti-HIV • Antibiotics for Angiogenesis Research
 
 
ALX-380-136 Revised 05-Jan-09 New product
Reductiomycin
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SYNONYMS AM-6201
S 551II
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-136-M001   1 mg 90.00 USD Add To Cart
ALX-380-136-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C14H15NO6
MW: 293.3
CAS NUMBER: 68748-55-0
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR and UV.

Product Description
Antibiotic. Shows antibacterial, antifungal, antiviral and antitumor activity.
Product Specific Literature References
Reductiomycin, a new antibiotic. I. Taxonomy, fermentation, isolation, characterization and biological activities: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 649 (1981) Abstract
Reductiomycin, a new antibiotic. II. Structural elucidation by spectroscopic studies: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 654 (1981) Abstract
Structure of antitumor alkaloid AM-6201: Y. Konda, et al.; J. Antibiot. (Tokyo) 34, 1222 (1981) Abstract
The alkaloid AM-6201 from Streptomyces xanthochromogenus: M. Onda, et al.; Chem. Pharm. Bull. 30, 1210 (1982)
Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus: H. Cho, et al.; JACS 115, 12296 (1993) Abstract
Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products: F. Li, et al.; Org. Lett. 9, 2923 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • Antibiotics - Antiviral / Anti-HIV • Alkaloids
 
 
ALX-380-201 Revised 27-Jun-08
Echinomycin
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SYNONYMS Quinomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-201-M001   1 mg 80.00 USD Add To Cart
ALX-380-201-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C51H64N12O12S2
MW: 1101.3
CAS NUMBER: 512-64-1
MERCK INDEX: 14: 3497
RTECS: JW5250000
SOURCE/HOST: Isolated from Streptomyces echinatus (DSM 40013).
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, dimethyl formamide or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: TOXIC. MAY BE MUTAGENIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antitumor antibiotic. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent inhibitor of hypoxia-inducible factor 1 (HIF-1) DNA binding activity. Induces apoptosis. Displays antibacterial, antifungal and antiviral activities.
Product Specific L