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Items 17 of 17
ALX-210-146
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α-1
SYNONYMS
anti-AR α-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-210-146-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 339-349 (K
339
FSREKKAAKT
349
) of human AR α-1 (adrenergic receptor α-1).
SPECIFICITY:
Recognizes human, mouse, rat, zebrafish and
Drosophila
AR α-1. Detects a band of ~60kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:1'000)
Western Blot (1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-147
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α2a
SYNONYMS
anti-Adrenoceptor α2a PAb
anti-Adrenoreceptor α2a PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-147-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.6mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 218-235 (R
218
IYQIAKRRTRV
PPSRRG
235
) of human AR α-2a (adrenergic receptor α-2a). This sequence is completely conserved in mouse, rat and pig AR α-2a.
SPECIFICITY:
Recognizes mouse and rat AR α-2a. Detects a band of ~45kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections (1:1’000))
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-148
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor β-1
SYNONYMS
anti-AR β-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-148-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.4mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.5mg/ml sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-408 (H
394
GDRPRASGCLARAG
408
) of mouse AR β-1 (adrenergic receptor β-1).
SPECIFICITY:
Recognizes mouse and rat AR β-1. Detects a band of ~64kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:500)
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-560
Revised 29-Nov-04
Polyclonal Antibody to Dopamine-β-hydroxylase
SYNONYMS
anti-DBH PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-560-R250
250 µl
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From sheep.
FORMULATION:
Liquid. Neat serum containing 0.2% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 43-62 (S
43
EPPESPFPY
HIPLDPEGTL
62
) of N-terminal rat DBH (dopamine-β-hydroxylase). This sequence is highly conserved (>85% homology) in human, bovine and mouse DBH.
SPECIFICITY:
Recognizes rat DBH. Specifically stains chromaffin cells of the adrenal medulla and DBH-containing cells of the sympathetic nervous system, including locus coeruleus and medulla oblongata. Cross-reactivity with other species has not been tested, but broad species cross-reactivity is expected due to conservation of the immunogenic sequence.
APPLICATION:
Immunocytochemistry (1:5'000-1:10'000)
Immunohistochemistry (frozen sections (1:20'000-1:50'000))
Western Blot (1:5'000-1:10'000 by ECL detection)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Dopamine-β-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to noradrenaline. Tissue specificity consists of chromaffin granules of the adrenal medulla and synaptic vesicles of the sympathetic nervous system. It exists as both, a soluble and membrane-bound form in chromaffin granules.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Adrenergics & Adrenergic Receptors / Related Products
ALX-350-092
Revised 03-Apr-08
Emetine . dihydrochloride
SYNONYMS
6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - DNA Replication Inhibitors
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ALX-350-092-M050
50 mg
10.00 USD
Product Specification
FORMULA:
C
29
H
40
N
2
O
4
. 2HCl
MW:
480.7 . 73.0
CAS NUMBER:
316-42-7
MERCK INDEX:
14:
3559
SOURCE/HOST:
Isolated from ground roots of
Uragoga ipecacuanha
.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Hygroscopic.
HAZARD:
TOXIC.
Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells:
A.P. Grollman; J. Biol. Chem.
243
, 4089 (1968)
Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A::
A: T. Schweighoffer, et al.; Histochemistry
96
, 93 (1991)
Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation:
W.C. Burhans, et al.; EMBO J.
10
, 4351 (1991)
Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells:
T. Kokuho, et al.; Immunobiology
193
, 42 (1995)
Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells:
Y.D. Zhou, et al.; J. Nat. Prod.
68
, 947 (2005)
Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells:
M. Moller, et al.; Oncol. Rep.
18
, 737 (2007)
Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines:
M. Moller & M. Wink; Planta Med.
73
, 1389 (2007)
Abstract
Further Categories Containing This Product:
DNA Replication Inhibitors
•
Translation Inhibitors
•
Natural Products - Other Anti-infective Agents
•
Parasitic Diseases Other Products
•
Adrenergics & Adrenergic Receptors / Related Products
•
Alkaloids
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Natural Products for Neurological Research
•
Other Toxins
ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
•
Adrenergics & Adrenergic Receptors / Related Products
•
Natural Products - Antitumor Reagents
•
Marine Natural Products
•
Alkaloids
ALX-350-111
Revised 04-Mar-05
Sibutramine . hydrochloride . monohydrate
SYNONYMS
1-(4-Chlorophenyl-
N,N
-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine . HCl . H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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ALX-350-111-M250
250 mg
25.00 USD
ALX-350-111-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
17
H
26
ClN . HCl . H
2
O
MW:
279.9 . 36.5 . 18.0
CAS NUMBER:
125494-59-9
MERCK INDEX:
14:
8485
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in methanol or water (2.9mg/ml at pH 5.2).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
MELTINGPOINT:
193-198°C
Product Description
Anti-obesity agent. Prevents resorption of the messenger substances serotonin and noradrenalin in the brain, allowing them to act at higher concentration on nerve cells and increasing the feeling of satiety.
Further Categories Containing This Product:
Obesity & Diabetes Other Products
•
Serotonergics & Serotonin Receptors / Related Products
ALX-430-039
Revised 06-May-08
Phenoxybenzamine . hydrochloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
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ALX-430-039-M100
100 mg
30.00 USD
Product Specification
FORMULA:
C
18
H
22
ClNO . HCl
MW:
303.8 . 36.5
CAS NUMBER:
63-92-3
MERCK INDEX:
14:
7256
RTECS:
DP3750000
PURITY:
≥95% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Irreversible calmodulin inhibitor. Also known for its selective α-adrenergic blocking activity.
Product Specific Literature References
Interaction of alpha adrenergic antagonists with calmodulin
:
C.Q. Earl, et al.; Life Sci.
35
, 524 (1984)
Abstract
In vivo recovery of alpha 1-adrenoceptors in rat myocardial tissue after alkylation with phenoxybenzamine:
J. Salles, et al.; Eur. J. Pharmacol.
266
, 35 (1994)
Abstract
Evidence for a functional interaction between calmodulin and the glucocorticoid receptor:
Y.M. Ning & E.R. Sanchez; BBRC
208
, 48 (1995)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-076
Revised 29-Apr-08
L-Norepinephrine . bitartrate . monohydrate
SYNONYMS
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol . C
4
H
6
O
6
. H
2
O
L-Noradrenaline . C
4
H
6
O
6
. H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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ALX-550-076-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
8
H
11
NO
3
. C
4
H
6
O
6
. H
2
O
MW:
169.2 . 150.1 . 18.0
CAS NUMBER:
69815-49-2
MERCK INDEX:
14:
6695
PURITY:
≥98% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions may oxidize when exposed to air.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Adrenergic neurotransmitter.
ALX-550-077
Revised 26-Apr-07
Clenbuterol . hydrochloride
SYNONYMS
4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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ALX-550-077-M050
50 mg
20.00 USD
ALX-550-077-M250
250 mg
50.00 USD
ALX-550-077-G001
1 g
150.00 USD
Product Specification
FORMULA:
C
12
H
18
Cl
2
N
2
O . HCl
MW:
277.2 . 36.5
CAS NUMBER:
21898-19-1
MERCK INDEX:
14:
2347
RTECS:
DN3180000
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
β
2
-Adrenergic receptor agonist. Bronchodilator.
Product Specific Literature References
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor:
F. Moroni, et al.; Eur. J. Pharmacol.
199
, 227 (1991)
Abstract
Function and regulation of the beta 3-adrenoceptor:
A.D. Strosberg & F. Pietri-Rouxel; TIPS
17
, 373 (1996), (Review)
Abstract
ALX-550-087
Revised 15-Sep-08
Clonidine . hydrochloride
SYNONYMS
2
-
(2,6
-
Dichloroanilino)
-
2
-
imidazoline . hydrochloride
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-550-087-M050
50 mg
23.00 USD
Product Specification
FORMULA:
C
9
H
9
Cl
2
N
3
. HCl
MW:
230.1 . 36.5
CAS NUMBER:
4205-91-8
MERCK INDEX:
14:
2390
RTECS:
