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Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-329 Revised 21-May-08
Allicin
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SYNONYMS 2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-329-M001   1 mg 200.00 USD Add To Cart
ALX-350-329-M005   5 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C6H10OS2
MW: 162.3
CAS NUMBER: 539-86-6
MERCK INDEX: 14: 261
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Clear to slightly yellow liquid.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract
 
 
ALX-350-330 Revised 05-Apr-08
Evodiamine
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SYNONYMS 8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-330-M010   10 mg 20.00 USD Add To Cart
ALX-350-330-M050   50 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C19H17N3O
MW: 303.4
CAS NUMBER: 518-17-2
MERCK INDEX: 14: 3908
SOURCE/HOST: Synthetic. Originally isolated from Evodia rutaecarpa.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in DMSO (5mg/ml; warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
A cell permeable, non-pungent vanilloid receptor agonist that induces apoptosis. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells.
Product Specific Literature References
Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci. 75, 612 (1986) Abstract
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod. 60, 708 (1997) Abstract
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull. 24, 917 (2001) Abstract
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci. 94, 92 (2003) Abstract
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin. 25, 83 (2004) Abstract
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis 26, 968 (2005) Abstract
Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther. 5, 2398 (2006) Abstract
 
 
ALX-350-350 Revised 21-Aug-08
Honokiol
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SYNONYMS 5,3’-Diallyl-2,4’-biphenyldiol
5,3’-Diallyl-2,4’-dihydroxydiphenyl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-350-M005   5 mg 40.00 USD Add To Cart
ALX-350-350-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 35354-74-6
MERCK INDEX: 14: 4742
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=6.4µM). Isomeric with magnolol (Prod. No. ALX-350-352). Inhibits NF-κB activation. Potent scavenger of superoxide and peroxyl radicals.
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells: S.E. Yang, et al.; Biochem. Pharmacol. 63, 1641 (2002) Abstract
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo: X. Bai, et al.; J. Biol. Chem. 278, 35501 (2003) Abstract; Full Text
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway: K.S. Ahn, et al.; Mol. Cancer Res. 4, 621 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression: B.H. Kim & J.Y. Cho; Acta Pharmacol. Sin. 29, 113 (2008) Abstract
Honokiol is a potent scavenger of superoxide and peroxyl radicals: S. Dikalov, et al.; Biochem. Pharmacol. 76, 589 (2008) Abstract
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ALX-350-353 Revised 16-Jun-08
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
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ALX-350-355 Revised 26-Mar-08
Lupeol
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SYNONYMS Fagarasterol
20(29)-Lupen-3β-ol
3β-Hydroxy-20(29)-lupene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-355-M010   10 mg 35.00 USD Add To Cart
ALX-350-355-M050   50 mg 105.00 USD Add To Cart
ALX-350-355-G001   1 g 990.00 USD Add To Cart
Product Specification
FORMULA: C30H50O
MW: 426.7
CAS NUMBER: 545-47-1
MERCK INDEX: 14: 5608
RTECS: OK5763000
SOURCE/HOST: Isolated from Lupinus polyphyllus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in ether or warm 100% ethanol; insoluble in water
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Anti-inflammatory, antioxidant and antimutagenic compound. Shows preventive effects on DMBA induced DNA alkylation damage in mouse skin. Modulator of NF-κB and PI(3)K/Akt (protein kinase B; PKB) pathways. Induces Fas-mediated apoptosis via inhibition of Ras signalling. Inhibits tumor growth in mouse in vivo.
Product Specific Literature References
Anti-inflammatory activity of lupeol and lupeol linoleate in rats: T. Geetha & P. Varalakshmi; J. Ethnopharmacol. 76, 77 (2001) Abstract
Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin: M. Saleem, et al.; Pharmacol. Res. 43, 127 (2001) Abstract
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice: M. Saleem, et al.; Oncogene 23, 5203 (2004) Abstract
Induction of antifertility with lupeol acetate in male albino rats: R.S. Gupta, et al.; Pharmacology 75, 57 (2005) Abstract
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model: M. Saleem, et al.; Cancer Res. 65, 11203 (2005) Abstract; Full Text
Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway: M. Saleem, et al.; Carcinogenesis 26, 1956 (2005) Abstract; Full Text
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda: J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) Abstract
Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats: S.P. Preetha, et al.; Comp. Biochem. Physiol C. Toxicol. Pharmacol. 143, 333 (2006) Abstract
Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia: V. Sudhahar, et al.; Life Sci. 78, 1329 (2006) Abstract
Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin: N. Nigam, et al.; Food Chem. Toxicol. 45, 2331 (2007) Abstract
Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model: T.K. Lee, et al.; Cancer Res. 67, 8800 (2007) Abstract
 
 
ALX-350-361 Revised 17-Mar-08
Auraptene
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SYNONYMS 7-Geranyloxycoumarin
7-[(2E)-3,7-Dimethylocta-2,6-dienoxy]chromen-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
Ordering Information
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ALX-350-361-M005   5 mg 25.00 USD Add To Cart
ALX-350-361-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C19H22O3
MW: 298.4
CAS NUMBER: 495-02-3
SOURCE/HOST: Isolated from citrus fruit.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by NMR.

Product Description
Anti-inflammatory and chemopreventive compound. Exerts tumor preventive effects through apoptosis. Suppresses cell proliferation and lipid peroxidation. Acts as an agonist of PPARs. Induces phase II drug-metabolizing enzymes.
Product Specific Literature References
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes: T. Tanaka, et al.; Cancer Res. 58, 2550 (1998) Abstract; Full Text
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice: T. Tanaka, et al.; Carcinogenesis 20, 1471 (1999) Abstract; Full Text
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells: H. Mori, et al.; Mutat. Res. 480-481, 201 (2001) Abstract
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins: M. Curini, et al.; Bioorg. Med. Chem. Lett. 14, 2241 (2004) Abstract
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism: K. Kawabata, et al.; FEBS Lett. 580, 5288 (2006) Abstract
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes: K. Kuroyanagi, et al.; BBRC 366, 219 (2008) Abstract
 
 
ALX-350-365 Revised 07-Oct-08
Cinnamtannin B-1
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SYNONYMS Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-365-M005   5 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C45H36O18
MW: 864.7
CAS NUMBER: 88082-60-4
SOURCE/HOST: Isolated from Laurus nobilis L.
PURITY: ≥90% (1H-NMR)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
A-type proanthocyanidin contained in several plant species such as Laurus nobilis L., Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum and Lindera umbellata. Potent antioxidant. Protective agent against oxidative stress and apoptosis in human platelets.
Product Specific Literature References
Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice: N. Ezaki, et al.; Planta Med. 51, 34 (1985) Abstract
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992) Abstract
Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999) Abstract
Studies on the constituents of bark of Parameria laevigata Moldenke: K. Kamiya, et al.; Chem. Pharm. Bull. 49, 551 (2001) Abstract; Full Text
Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004) Abstract
Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006) Abstract
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007) Abstract
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007) Abstract
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and VegetablesFlavanolsNatural Products - Antioxidants
 
 
ALX-350-372 Revised 10-Jul-08
Thiocolchicine
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SYNONYMS N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-372-M001   1 mg 50.00 USD Add To Cart
ALX-350-372-M005   5 mg 150.00 USD Add To Cart
ALX-350-372-M025   25 mg 450.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO5S
MW: 415.5
CAS NUMBER: 2730-71-4
MERCK INDEX: 14: 9324
SOURCE/HOST: Semisynthetic.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in 100% ethanol or acetone; almost insoluble in water or ether.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: