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ALX-210-744
Revised 27-Apr-06
Polyclonal Antibody to TRAIL-R3 (human)
SYNONYMS
anti-DcR1 (human) PAb
anti-TRID (human) PAb
anti-TNFRSF 10C (human) PAb
anti-CD263 (human) PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
TRAIL-R3
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-744-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 33-63 (E
33
VPQQTVAPQQQRHSFKGEECPAGSHRSEHT
63
) of the extracellular domain of human TRAIL-R3 (DcR1).
SPECIFICITY:
Recognizes human TRAIL-R3. Detects a band of ~33kDa by Western blot.
APPLICATION:
Flow Cytometry (1µl/10
6
cells/100µl)
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot or Immunocytochemistry on cell lines HEK 293 or Jurkat.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-006
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein:
J.R. Basile et al.; J. Biol. Chem.
276
, 22522 (2001)
Abstract
;
Full Text
Rel/NF-κB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1
:
D. Bernard, et al.; J. Biol. Chem.
276
, 27322 (2001)
Abstract
;
Full Text
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan
:
M. Dejosez, et al.; Cell Death Differ.
7
, 1127 (2000)
Abstract
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain
:
J. Dörr, et al.; J. Neurosci.
22
, RC209 (2002)
Abstract
;
Full Text
General Literature References
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
:
M.A. Degli-Esposti, et al.; J. Exp. Med.
186
, 1165 (1997)
Abstract
;
Full Text
Characterization of two receptors for TRAIL:
P. Schneider, et al.; FEBS Lett.
416
, 329 (1997)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-799
Revised 16-Apr-07
Polyclonal Antibody to BAFF (CT)
SYNONYMS
anti-BLyS (CT) PAb
anti-TALL-1 (CT) PAb
anti-THANK (CT) PAb
anti-zTNF4 (CT) PAb
anti-TNFSF 13B/20 (CT) PAb
anti-CD257 (CT) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
BAFF
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-799-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Ion exchange chromatography purified IgG.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 254-269 of human BAFF.
SPECIFICITY:
Recognizes human, mouse and rat BAFF.
APPLICATION:
Western Blot (0.25-1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1 year after receipt when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
BAFF production by antigen-presenting cells provides T cell co-stimulation
:
B. Huard, et al.; Int. Immunol.
16
, 467 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-800
Revised 27-Nov-08
Polyclonal Antibody to TACI
SYNONYMS
anti-Transmembrane Activator and CAML Interactor PAb
anti-TNFRSF 13B PAb
anti-CD267 PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
TACI
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-800-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 116-132 of human TACI (transmembrane activator and CAML interactor). This sequence is 65% conserved in mouse TACI.
SPECIFICITY:
Recognizes human and mouse TACI. Detects a band of ~32kDa by Western blot.
APPLICATION:
Western Blot (0.1-0.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Human spleen, Daudi or RAW cells are recommended as positive control.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-825
Revised 08-Dec-04
Polyclonal Antibody to CD137 (mouse)
SYNONYMS
anti-4-1BB (mouse) PAb
anti-TNFRSF 9 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CD137 & CD137L / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-825-C100
100 µg
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.9mg/ml
FORMULATION:
Liquid. 100µg of purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 243-256 (C
243
PQEEEGGGGGYEL
256
) of the C-terminal cytoplasmic domain of mouse CD137 (4-1BB).
SPECIFICITY:
Recognizes mouse CD137.
APPLICATION:
Immunoprecipitation
Western Blot (recommended starting dilution: 1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family:
L.A. Gravestein, et al.; Eur. J. Immunol.
23
, 943 (1993)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-826
Revised 08-Dec-04
Polyclonal Antibody to CD27 (mouse)
SYNONYMS
anti-TNFRSF 7 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CD27 & CD27L [CD70] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-826-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. 100µg of purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CD27 corresponding to aa 208-250 (H
208
GPNEDRQAVPEEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP
250
) of the cytoplasmic domain.
SPECIFICITY:
Recognizes mouse CD27.
APPLICATION:
Immunoprecipitation
Western Blot (recommended starting dilution: 1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2:
L.A. Gravestein, et al.; Eur. J. Immunol.
28
, 2208 (1998)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-828
Revised 23-Jun-08
Polyclonal Antibody to CD3ζ (22-30)
SYNONYMS
anti-CD247 (22-30) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD3 - Marker for T Cells
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-828-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 22-30 (Q
22
SFGLLDPK
30
) of human CD3ζ.
SPECIFICITY:
Recognizes human and mouse CD3ζ. Cross-reacts with CD3η.
For the detection of the cytoplasmic domain of CD3ζ, we recommend Prod. No.
ALX-210-829
.
APPLICATION:
Immunoprecipitation
(can be used with the detergent NP-40, but not with digitonin)
Western Blot
(1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
The Signaling Adaptor Protein CD3ζ Is a Negative Regulator of Dendrite Development in Young Neurons:
SJ. Baudouin, et al.; Mol. Biol. Cell
6
, 2444 (2008)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-829
Revised 22-Feb-05
Polyclonal Antibody to CD3ζ (154-164)
SYNONYMS
anti-CD247 (154-164) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD3 - Marker for T Cells
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-829-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 154-164 (D
154
ALHMQALPPR
164
) of human CD3ζ.
SPECIFICITY:
Recognizes human and mouse CD3ζ. Does not cross-react with CD3η.
For the detection of the extracellular domain of CD3ζ
we recommend Prod. No.
ALX-210-828
.
APPLICATION:
Immunoprecipitation
(can be used with either NP-40 or digitonin as detergent)
Western Blot
(1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface
:
P. Isomaki, et al.; J. Immunol.
166
, 5495 (2001)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-852
Revised 27-Jul-06
Polyclonal Antibody to Toll-like Receptor 2 (human)
SYNONYMS
anti-TLR2 (human) PAb
anti-Toll/Interleukin-1 Receptor-like Gene 4 (human) PAb
anti-TIL4 (human) PAb
anti-CD282 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-852-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 179-204 (L
179
EIDASDLQSY
EPKSLKSIQNVSHLI
204
) of human TLR2 (Toll-like receptor 2).
SPECIFICITY:
Recognizes human TLR2.
APPLICATION:
Flow Cytometry
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250))
Western Blot
QUALITY CONTROL:
Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-011
.
General Information
Note: Human Toll-like Receptor 2 (TLR2) is also described as Toll/Interleukin-1 Receptor-like Gene 4 (TIL4).
General Literature References
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans
:
P.M. Chaudhary, et al.; Blood
91
, 4020 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-873
Revised 02-Jun-08
Polyclonal Antibody to Toll-like Receptor 6
SYNONYMS
anti-TLR6 PAb
anti-CD286 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-873-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to a portion of mouse TLR6 (Toll-like receptor 6).
SPECIFICITY:
Recognizes human and mouse TLR6. Detects a band of ~92kDa by Western blot.
APPLICATION:
Flow Cytometry (2µg/10
6
cells)
Western blot (1-2µg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract:
M.A. Palladino, et al; Biol. Reprod.
76
, 958 (2007)
Abstract
General Information
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The aa sequence of human TLR6 is most similar to hTLR1 with 69% identity at the aa level. Human TLR6 consists of a predicted 807 aa with a molecular weight of approximately 92 kDa. Human and mouse TLR6 share an aa identity of 73%. TLR6 activates both NF-κB and c-Jun N-terminal Kinase (JNK). The aa in the cytoplasmic domain of IL-1 receptor, which are critical for NF-κB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6. TLR6 is predominantly expressed in spleen, thymus, ovary, and lung.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-921
Revised 31-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor (human) (AT101)
SYNONYMS
anti-NGFR (human) PAb (AT101)
anti-TNFRSF 16 (human) PAb (AT101)
anti-p75
NTR
(human) PAb (AT101)
anti-p75 Neurotrophin Receptor (human) PAb (AT101)
anti-CD271 (human) PAb (AT101)
anti-Low-affinity Nerve Growth Factor Receptor (human) PAb (AT101)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-921-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide
IMMUNOGEN:
Recombinant human NGFR (nerve growth factor receptor; p75
NTR
) (Prod. No.
ALX-522-044
).
SPECIFICITY:
Recognizes human NGFR.
APPLICATION:
Western Blot (1:1’000)
Note:
Does not work for Immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells:
A. Tanaka, et al.; BBRC
313
, 1009 (2004)
Abstract
p75NTR--live or let die:
A. Nykjaer, et al.; Curr. Opin. Neurobiol.
15
, 49 (2005)
Abstract
Further Categories Containing This Product:
Neurotensin / Related Products
•
Polyclonal Antibodies
•
CD Antibodies
ALX-210-950
Revised 29-Oct-07
Polyclonal Antibody to APRIL (Membrane Form) (human) (AT125)
SYNONYMS
anti-A-Proliferation-inducing Ligand (Membrane Form) (human) PAb (AT125)
anti-TNFSF 13 (Membrane Form) (human) PAb (AT125)
anti-CD256 (Membrane Form) (human) PAb (AT125)
