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Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
You are here: Product Lines > Bone Metabolism > Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-204/1-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~85.5kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100μg/ml after reconstitution.
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized from 0.1M K-HEPES, pH 7.0, containing 3% mannitol.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 100μl distilled water at +4°C for 30 minutes.
BIOLOGICAL ACTIVITY: Administration leads to ectopic bone formation in rats.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: The reconstituted solution can be diluted into other aqueous buffers and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor : F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-205/1 Revised 17-Jun-08 New product
Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS BMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-205/1-C010   10 µg 280.00 USD Add To Cart
Product Specification
MW: ~25.9kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100-500μg/ml after reconstitution. 
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 20-100μl 50mM sodium acetate solution, pH 4.3.
BIOLOGICAL ACTIVITY: Induces alkaline phosphatase expression at an EC50 = 14nM in C2C12 cells.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

The reconstituted solution can be further diluted in sodium acetate solution and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor: F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-804-851 Revised 03-May-07
Monoclonal Antibody to RGMC (human) (Fery-1)
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SYNONYMS anti-Repulsive Guidance Molecule C (human) MAb (Fery-1)
anti-Hemojuvelin (human) MAb (Fery-1)
anti-Hemochromatosis Type 2 Protein (human) MAb (Fery-1)
anti-HFE2 (human) MAb (Fery-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
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ALX-804-851-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Fery-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMC (aa 36-398) (Prod. No. ALX-522-104).
SPECIFICITY: Recognizes human RGMC.
APPLICATION: Flow Cytometry
Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
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Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-210-937 Revised 28-Apr-08
Polyclonal Antibody to RGMA (human) (AT115)
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SYNONYMS anti-Repulsive Guidance Molecule A (human) PAb (AT115)
anti-RGM Domain Family Member A (human) PAb (AT115)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
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ALX-210-937-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RGMA (aa 48-422) (Prod. No. ALX-522-103).
SPECIFICITY: Recognizes human RGMA.
APPLICATION: Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products • Polyclonal Antibodies
 
 
ALX-522-103 Revised 19-Aug-08
RGMA, Soluble (human) (recombinant)
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SYNONYMS Repulsive Guidance Molecule A, Soluble (human) (recombinant)
RGM Domain Family Member A, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
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ALX-522-103-2010   2x10 µg 240.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human RGMA (aa 48-422) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
The Neogenin Intracellular Domain Regulates Gene Transcription via Nuclear Translocation: D. Goldschneider, et al.; Mol. Cell. Biol. 28, 4068 (2008) Abstract
General Information
The RGMA is an GPI-anchored protein involved in the axon guidance and is predominantly expressed in the developing and adult central nervous system in mouse. RGMA inhibits mammalian CNS neurite outgrowth. The protein acts as co-receptor of the bone morphogenetic protein. The mature RGMA protein is proteolytically processed and is glycosylated.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q96B86: Repulsive Guidance Molecule A (human) (Precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor: J.L. Babitt, et al.; J. Biol. Chem. 280, 29820 (2005) Abstract; Full Text
RGMa inhibition promotes axonal growth and recovery after spinal cord injury: K. Hata, et al.; J. Cell Biol. 173, 47 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
 
 
ALX-522-134 Revised 05-May-08
RGMA, Soluble (mouse) (recombinant)
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SYNONYMS Repulsive Guidance Molecule A, Soluble (mouse) (recombinant)
RGM Domain Family Member A, Soluble (mouse) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
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ALX-522-134-2010   2x10 µg 240.00 USD Add To Cart
Product Specification
MW: ~16kDa
SOURCE/HOST: Produced in HEK 293 cells. Mouse RGMA (repulsive guidance molecule A) (aa 48-423) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6PCX7: RGMA (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
 
 
ALX-522-139 Revised 16-Jun-08 New product
RGMB, Soluble (human) (recombinant)
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SYNONYMS RGM Domain Family Member B, Soluble (human) (recombinant)
Repulsive Guidance Molecule B, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-139-C010   10 µg 300.00 USD Add To Cart
Product Specification
MW: ~32kDa
SOURCE/HOST: Produced in CHO cells. Human RGMB (RGM domain family member B) (aa 46-412) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6NW40: RGMB (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
 
 
ALX-522-104 Revised 19-Aug-08
RGMC, Soluble (human) (recombinant)
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SYNONYMS Repulsive Guidance Molecule C, Soluble (human) (recombinant)
Hemojuvelin, Soluble (human) (recombinant)
Hemochromatosis Type 2 Protein, Soluble (human) (recombinant)
HFE2, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Repulsive Guidance Molecules [RGMs] & Neogenin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-104-C010   10 µg 290.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human RGMC (aa 36-398) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6ZVN8: Repulsive Guidance Molecule C (human) (Precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
RGM and its receptor neogenin regulate neuronal survival: E. Matsunaga, et al.; Nat. Cell Biol. 6, 749 (2004) Abstract
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload: V. Niederkofler, et al.; J. Clin. Invest. 115, 2180 (2005) Abstract
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression: J.L. Babitt, et al.; Nat. Genet. 38, 531 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
 
 
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