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ALX-805-073
Revised 04-Jan-06
Monoclonal Antibody to CD59 (human) (MEM-43)
SYNONYMS
anti-Protectin (human) MAb (MEM-43)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-073-C100
100 µg
195.00 USD
ALX-805-073F-T100
FITC
100 tests
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MEM-43
ISOTYPE:
Mouse IgG2a
SOURCE/HOST:
Purified from hybridoma culture supernatant by protein A affinity chromatography.
CONCENTRATION:
MEM-43
: 1mg/ml
PURITY:
>95% (SDS-PAGE)
FORMULATION:
MEM-43
: Liquid. In PBS, pH 7.4, containing 0.1% sodium azide.
MEM-43-
FITC
: Liquid. In PBS, pH 7.4, containing BSA and 0.1% sodium azide.
IMMUNOGEN:
Thymocytes and T lymphocytes.
SPECIFICITY:
Recognizes a well defined epitope (W40, R-53) on human CD59 (protectin).
APPLICATION:
MEM-43
:
Flow Cytometry
Immunoprecipitation
MEM-43-
FITC
:
Flow Cytometry (for human blood analysis use 20µl/100µl whole blood).
SHIPPING:
SHIPPED ON BLUE ICE
USE/STABILITY:
MEM-43
: Short term storage at +4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
MEM-43-FITC
: Store at +4°C. Do not freeze! Protect from light!
Product Specific Literature References
Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen
:
V. Horejsi, et al.; Folia Biol. (Praha)
32
, 12 (1986)
Abstract
Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11
:
U.H. Forsberg, et al.; Immunogenetics
30
, 188 (1989)
Abstract
Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol
:
I. Stefanova, et al.; Mol. Immunol.
26
, 153 (1989)
Abstract
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases
:
I. Stefanova, et al.; Science
254
, 1016 (1991)
Abstract
The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases
:
T. Cinek & V. Horejsi; J. Immunol.
149
, 2262 (1992)
Abstract
CD59 molecule: a second ligand for CD2 in T cell adhesion:
M. Deckert, et al.; Eur. J. Immunol.
22
, 2943 (1992)
Abstract
Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells
:
M. Cebecauer, et al.; BBRC
243
, 706 (1998)
Abstract
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules:
L. Cermak, et al.; J. Biol. Chem.
277
, 7955 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Complement Regulators / Related Products
•
Monoclonal Antibodies
ALX-805-074
Revised 11-Sep-07
Monoclonal Antibody to CD59 (MEM-43/5)
SYNONYMS
anti-Protectin MAb (MEM-43/5)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-074-C100
100 µg
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
MEM-43/5
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Thymocytes and T lymphocytes.
SPECIFICITY:
Recognizes a well defined epitope (around L33) on human and mouse CD59 (protectin) and does not compete with most other CD59 antibodies.
APPLICATION:
Flow Cytometry
Immunoprecipitation
Western Blot (non-reducing conditions)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Mutational Analysis of the Active Site and Antibody Epitopes of the Complement-inhibitory Glycoprotein, CD59:
D. L. Bodian et al.; J. Exp. Med.
185
, 507 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Complement Regulators / Related Products
•
Monoclonal Antibodies
ALX-805-077
Revised 14-Sep-07
Monoclonal Antibody to CD66e (human) (26/3/13)
SYNONYMS
anti-CEACAM5 (human) MAb (26/3/13)
anti-CEA (human) MAb (26/3/13)
anti-Carcinoembryonic Antigen (human) MAb (26/3/13)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
CEACAM [CD66] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-077-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
26/3/13
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.
IMMUNOGEN:
CD66e (CEACAM5; CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors.
SPECIFICITY:
Recognizes human CD66e. Does not cross-react with human CEACAM1, 3, 4, 6, 7, 8 or PSG.
APPLICATION:
ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Western Blot
Optimal conditions must be determined individually for each application.
QUALITY CONTROL:
Routinely tested by flow cytometry on BOSC cells transiently transfected with a CD66e expression vector.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns
:
F. Grunert, et al.; Int. J. Cancer
36
, 357 (1985)
Abstract
Effects of human bone marrow stroma on the growth of human tumor cells
:
E.S. Strobel, et al.; Cancer Res.
49
, 1001 (1989)
Abstract
A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members
:
J. Thompson, et al.; Int. J. Cancer
55
, 311 (1993)
Abstract
CD66 family workshop: binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules
:
F. Grunert, et al.; Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto, et al., eds.), Garland Publishing Inc., New York and London 1012 (1996)
CEA-related proteins on human urothelial cell lines of different transformation grades
:
A. Krop-Watorek, et al.; Cancer Lett.
139
, 15 (1999)
Abstract
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas
:
S. Scholzel, et al.; Am. J. Pathol.
156
, 595 (2000)
Abstract
;
Full Text
General Information
CD66e (CEACAM5; CEA) belongs to the carcinoembryonic antigen (CEA) gene family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a M
r
of 180'000-200'000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cells of the tongue, esophagus and cervix. CD66e is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).
MANUFACTURER
Manufactured by GENOVAC GmbH.
General Literature References
Carcinoembryonic antigen gene family: molecular biology and clinical perspectives
:
J.A. Thompson, et al.; J. Clin. Lab. Anal.
5
, 344 (1991), (Review)
Abstract
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues:
S. Hammarström; Semin. Cancer Biol.
9
, 67 (1999), (Review)
Abstract
Carcinoembryonic antigen
:
W. Zimmermann; Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York 459 (2002)
Further Categories Containing This Product:
Monoclonal Antibodies
•
CD Antibodies
ALX-805-052
Revised 10-Nov-04
Monoclonal Antibody to CD72 (human) (3F3)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-052-C100
100 µg
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
3F3
ISOTYPE:
Mouse IgG2b
IMMUNOGEN:
Normal human lymphocytes from a lymph node.
SPECIFICITY:
Recognizes human CD72.
APPLICATION:
Flow Cytometry
Immunoprecipitation
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Monoclonal Antibodies
•
B Cell Receptor [BCR] & Co-Receptors / Related Products
ALX-805-084
Revised 01-Feb-07
Monoclonal Antibody to CD80 (human) (MEM-233)
SYNONYMS
anti-B7-1 (human) MAb (MEM-233)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD28 / CD152 [CTLA-4] Family & Their Ligands / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-084-C100
100 µg
210.00 USD
ALX-805-084F-T100
FITC
100 tests
315.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MEM-233
ISOTYPE:
Mouse IgG1
CONCENTRATION:
MEM-233:
1mg/ml
MEM-233-FITC:
Vial content (2ml) is sufficient for 100 tests.
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
MEM-233:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
MEM-233-FITC:
Liquid. In PBS containing 15mM sodium azide and 0.2% BSA.
IMMUNOGEN:
Recombinant human CD80.
SPECIFICITY:
Recognizes human CD80.
APPLICATION:
MEM-233:
Flow Cytometry
Immunoprecipitation
MEM-233-FITC:
Flow Cytometry (use 20µl reagent / 100µl of whole blood or 10
6
cells in a suspension)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Specific Literature References
Cross-linking of neutrophil CD11b results in rapid cell surface expression of molecules required for antigen presentation and T-cell activation:
G.P. Sandilands, et al.; Immunology
114
, 354 (2005)
Abstract
;
Full Text
Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment:
D. Campioni, et al.; Haematologica
91
, 364 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
•
CD Antibodies
ALX-805-045
Revised 26-Jul-07
Monoclonal Antibody to CD83 (human) (1G11)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-045-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
1G11
ISOTYPE:
Rat IgG1
CONCENTRATION:
1.9mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant human CD83 (extracellular domain).
SPECIFICITY:
Recognizes human CD83. The binding affinity strongly increases after deglycosylation of mature DC.
APPLICATION:
Flow Cytometry, Western blot.
Not
inhibitory to DC mediated T cell stimulation in mixed lymphocyte reactions.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Do not freeze/thaw.
Product Specific Literature References
The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells
:
M. Lechmann, et al.; J. Exp. Med.
194
, 1813 (2001)
Abstract
;
Full Text
Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies
:
M. Lechmann, et al.; Protein Exp. Purif.
24
, 445 (2002)
Abstract
Further Categories Containing This Product:
Dendritic Cells [DC]
•
Monoclonal Antibodies
ALX-805-044
Revised 10-Nov-04
Monoclonal Antibody to CD83 (human) (4B5)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-044-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
4B5
ISOTYPE:
Rat IgG2a
CONCENTRATION:
1.7mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant human CD83 (extracellular domain).
SPECIFICITY:
Recognizes human CD83. Deglycosylated CD83 is only weakly recognized.
APPLICATION:
Flow Cytometry
Western Blot
Note:
NOT inhibitory to DC mediated T cell stimulation in mixed lymphocyte reactions.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Do not freeze/thaw.
Product Specific Literature References
The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells
:
M. Lechmann, et al.; J. Exp. Med.
194
, 1813 (2001)
Abstract
;
Full Text
Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies
:
M. Lechmann, et al.; Protein Exp. Purif.
24
, 445 (2002)
Abstract
Further Categories Containing This Product:
Dendritic Cells [DC]
•
Monoclonal Antibodies
ALX-805-075
Revised 10-Nov-04
Monoclonal Antibody to CD97 (MEM-180)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-075-C100
100 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MEM-180
ISOTYPE:
Mouse IgG1
IMMUNOGEN:
PHA-activated PBL.
SPECIFICITY:
Recognizes a unique epitope on human CD97 (CD55 ligand).
APPLICATION:
Flow Cytometry
Immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Complement Regulators / Related Products
•
Monoclonal Antibodies
ALX-805-042
Revised 04-Jan-06
Monoclonal Antibody to CD99R (human) (MEM-131)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-042-C100
100 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MEM-131
ISOTYPE:
Mouse IgM
FORMULATION:
Contains 0.05% sodium azide.
IMMUNOGEN:
Human T cell line HPB-ALL.
SPECIFICITY:
Recognizes human CD99R.
APPLICATION:
Flow Cytometry
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules:
L. Cermak, et al.; J. Biol. Chem.
277
, 7955 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-845
Revised 02-Apr-07
Monoclonal Antibody to CD134 (human) (Nicky-1)
SYNONYMS
anti-OX40 (human) MAb (Nicky-1)
anti-TNFRSF 4 (human) MAb (Nicky-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-845-C100
100 µg
320.00 USD
ALX-804-845TD-T100
ATTO 488
100 tests
390.00 USD
ALX-804-845TS-T100
ATTO 647N
100 tests
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Nicky-1
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human CD134 (OX40) (aa 29-214) (Prod. No.
ALX-522-022
).
SPECIFICITY:
Recognizes human CD134.
APPLICATION:
Flow Cytometry
Immmunoprecipitation (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
Please click on thumbnails to enlarge.
Product Description
New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes:
E. Biagi, et al.; Blood
105
, 2436 (2005)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
•
CD Antibodies
