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Caspase Inhibitors
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Caspases / Related Products > Caspase Inhibitors
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ALX-260-102 Revised 02-Jan-06
Z-LE(OMe)TD(OMe)-FMK
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SYNONYMS Caspase-8 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-102-M001   1 mg 310.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
FORMULA: C30H44FN4O11
MW: 655.7
PURITY: ≥95% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Prepare a stock solution of 20 mM in high purity DMSO. Stock solutions are stable for up to 6-8 months when stored at –20°C. Add 2 µl above stock solutions to 1 ml of culture medium containing cells to give final DMSO concentration of 0.2%. Higher levels of DMSO may cause some cellular toxicity masking the effect of the ICE protease inhibitors.
HANDLING: Hygroscopic.
Product Description
Inhibitor of caspase-8.
 
 
ALX-260-142 Revised 04-Jan-06
Z-LEVD-FMK (Ready-to-Use)
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SYNONYMS Caspase-4 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-142-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-142-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Leu-Glu-Val-Asp-fluoromethylketone
MW: 652.0
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-4. Inhibits also caspase-5.
Product Specific Literature References
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003) Abstract; Full Text
Keratin 8/18 breakdown and reorganization during apoptosis: B. Schutte, et al.; Exp. Cell Res. 297, 11 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-104 Revised 14-Oct-08
Z-LE(OMe)VD(OMe)-FMK
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SYNONYMS Caspase-1 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-104-M001   1 mg 220.00 USD Add To Cart
ALX-260-104-M005   5 mg 890.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
FORMULA: C31H45FN4O10
MW: 652.7
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO (20mM) or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
Product Description
Non-cytotoxic inhibitor of caspase-1.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2-10µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-020 Revised 03-Sep-08
Z-VAD-FMK
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SYNONYMS Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-020-M001   1 mg 97.00 USD Add To Cart
ALX-260-020-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Ala-DL-Asp-fluoromethylketone
FORMULA: C21H28FN3O7
MW: 453.5
PEPTIDE CONTENT: 77-97%
PURITY: ≥92% (HPLC)
APPEARANCE: White to yellowish powder.
SOLUBILITY: Soluble in DMSO or acetonitrile (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only the amount needed at one time because of the possibility of decomposition in solution.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells: H. Zhu, et al.; FEBS Lett. 374, 303 (1995) Abstract
Neuroprotection by a caspase inhibitor in acute bacterial meningitis: J.S. Braun, et al.; Nat. Med. 5, 298 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Can be used as a broad spectrum caspase inhibitor. Prepare a 10mM stock solution of the caspase inhibitor in high quality DMSO. Add 2µl of this stock solution to 1ml of culture medium containing cells to give 20µM final concentration. Effective final concentrations are estimated to be 5-20 µM. If a particular caspase inhibitor is applied at higher concentrations specificity for an individual caspase or even for the caspase family (> 100µM) might be compromised. DMSO concentration above 0.2% may cause cellular toxicity thus masking the effect of the caspase inhibitor. For in vivo experiments extending for 12 to 48 hours, fresh inhibitor may have to be added (injected) due to inactivation by reaction with cysteine protease.
 
 
ALX-260-138 Revised 27-Sep-07
Z-VAD-FMK (Ready-to-Use)
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SYNONYMS Caspase Family Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-138-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-138-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Ala-Asp-fluoromethylketone
FORMULA: C22H30FN3O7
MW: 467.5
PURITY: ≥99% (TLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
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Product Description
Synthetic peptide that irreversibly inhibits ICE-family protease/caspase activity and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2-10µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
General Literature References
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32: E.A. Slee, et al.; Biochem. J. 315, 21 (1996) Abstract; Full Text
Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors: R.C. Armstrong, et al.; J. Biol. Chem. 271, 16850 (1996) Abstract; Full Text
Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells: X.M. Qi, et al.; Oncogene 15, 1207 (1997) Abstract
 
 
ALX-260-039 Revised 05-Jan-06
Z-VAD(OMe)-FMK
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SYNONYMS Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-039-M001   1 mg 170.00 USD Add To Cart
ALX-260-039-M005   5 mg 585.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA: C22H30N3O7F
MW: 467.5
CAS NUMBER: 187389-52-2
PURITY: ≥95.0%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Keep cool and dry.
Product Description

Irreversible and cell permeable broad-spectrum caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). For cell free assays use Prod. No. ALX-260-020.
Product Specific Literature References
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes: S.C. Chow, et al.; FEBS Lett. 364, 134 (1995) Abstract
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells: H. Zhu, et al.; FEBS Lett. 374, 303 (1995) Abstract
Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996) Abstract
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32: E.A. Slee, et al.; Biochem. J. 315, 21 (1996) Abstract; Full Text
A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice: A. Farber, et al.; J. Vasc. Surg. 30, 752 (1999) Abstract; Full Text
Correlation of tumor necrosis factor α (TNF α) with high Caspase 3-like activity in myelodysplastic syndromes: S.D. Mundle, et al.; Cancer Lett. 140, 201 (1999) Abstract
TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk: P.F. Piguet, et al.; Lab. Invest. 79, 495 (1999) Abstract
Monocytic cell necrosis is mediated by potassium depletion and caspase-like protease: M. Warny & C.P. Kelly; Am. J. Physiol. 276, C717 (1999) Abstract; Full Text
Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation: Z. Dong, et al.; Biochem. J. 347, 669 (2000) Abstract; Full Text
Apoptosis in Alzheimer's disease--an update: S. Shimohama; Apoptosis 5, 9 (2000) Abstract
Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo: C. Wiessner, et al.; Cell Mol. Biol. (Noisy-Le-Grand) 46, 53 (2000) Abstract
 
 
ALX-260-139 Revised 01-Sep-05
Z-VDVAD-FMK (Ready-to-Use)
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SYNONYMS Caspase-2 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-139-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-139-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Asp-Val-Ala-Asp-fluoromethylketone
MW: 695.0
PURITY: ≥98% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-2.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-099 Revised 14-Feb-07
Z-VD(OMe)VAD(OMe)-FMK
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SYNONYMS Caspase-2 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-099-M001   1 mg 330.00 USD Add To Cart
ALX-260-099-M005   5 mg 988.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA: C32H46FN5O11
MW: 695.7
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Store stock solutions in aliquots at -20°C.
HANDLING: Keep cool and dry.
Product Description
Irreversible, cell permeable inhibitor of caspase-2.
Product Specific Literature References
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997) Abstract; Full Text
Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors: P.A. Gregoli & M.C. Bondurant; J. Cell Physiol. 178, 133 (1999) Abstract
Distinct pathways for stimulation of cytochrome c release by etoposide: J.D. Robertson, et al.; J. Biol. Chem. 275, 32438 (2000) Abstract; Full Text
 
 
ALX-260-143 Revised 05-Dec-05
Z-VEID-FMK (Ready-to-Use)
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SYNONYMS Caspase-6 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-143-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-143-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Glu-Ile-Asp-fluoromethylketone
MW: 652.0
PURITY: ≥98% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-6.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
 
ALX-260-075 Revised 14-Feb-07
Z-VE(OMe)ID(OMe)-FMK
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SYNONYMS Caspase-6 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-075-M001   1 mg 330.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone
FORMULA: C31H45FN4O10
MW: 652.9
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Store stock solutions in aliquots at –20°C.
HANDLING: Packaged under inert gas.
Product Description
Irreversible, cell permeable inhibitor of caspase-6.
 
 
ALX-260-166 Revised 21-Oct-08
Z-VRPR-FMK
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SYNONYMS Z-Val-Arg-Pro-DL-Arg-FMK . TFA
MALT1 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-166-MC05   0.5 mg 280.00 USD Add To Cart
ALX-260-166-M001   1 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
FORMULA: C31H49FN10O6 . C2HF3O2
MW: 676.8 . 114.0
PURITY: ≥90% (HPLC)
APPEARANCE: White to slightly yellow powder.
SOLUBILITY: Soluble in water (1mg/ml).
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
The proteolytic activity of the paracaspase MALT1 is key to NF-κB and T cell activation. Z-VRPR-FMK is a selective MALT1 inhibitor of such proteolytic activity.
Product Specific Literature References
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008) Abstract