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ALX-460-036
Revised 17-Jan-05
Alfacalcidol
SYNONYMS
Hydroxyvitamin D
3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
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ALX-460-036-M001
1 mg
75.00 USD
Product Specification
FORMULA:
C
27
H
44
O
2
MW:
400.6
CAS NUMBER:
41294-56-8
RTECS:
VS2851000
PURITY:
≥97%
APPEARANCE:
White to off white crystals.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No.
ALX-460-032
)
in vivo
. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
ALX-460-032
Revised 18-Dec-07
Calcitriol
SYNONYMS
Vitamin D
3
, 1α,25-Dihydroxy-
1α,25-Dihydroxyvitamin D
3
1,25(OH)
2
D
3
1α,25-Dihydroxycholecalciferol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-032-C100
100 µg
150.00 USD
ALX-460-032-M001
1 mg
350.00 USD
Product Specification
FORMULA:
C
27
H
44
O
3
MW:
416.7
CAS NUMBER:
32222-06-3
MERCK INDEX:
14:
1644
RTECS:
FZ4645000
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Slightly soluble in methanol, 100% ethanol, ethyl acetate or tetrahydrofuran.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. MAY BE TERATOGENIC.
Product Description
Osteotropic hormone that up-regulates RANKL level and down-regulates OPG level. Biologically active form of vitamin D
3
in intestinal calcium transport and bone calcium resorption.
Product Specific Literature References
A rapidly acting metabolite of vitamin D3:
Haussler, et al.; PNAS
68
, 177 (1971)
Abstract
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture:
Raisz, et al.; Science
175
, 768 (1972)
Abstract
Further Categories Containing This Product:
Vitamins
ALX-804-021
Revised 21-Jul-08
Monoclonal Antibody to Vitamin D3 Receptor (9A7)
SYNONYMS
anti-VDR MAb (9A7)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-804-021-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE:
9A7
ISOTYPE:
Rat IgG2b
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody containing 0.05% sodium azide.
IMMUNOGEN:
Partially purified chicken intestinal cytoplasmic VDR (vitamin D
3
receptor).
SPECIFICITY:
Recognizes the occupied and unoccupied forms of VDR in human, mouse, rat, hamster, chicken, amphibian and fish. Recognizes an epitope between aa 89 and 105 of human VDR. In avians detects bands of ~58kDa and ~60kDa by Western blot, while in mammalian species the VDRs appear as a single band within the ~52-55kDa range.
Does not cross-react with ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION:
Gel Supershift Assays
Immunocytochemistry
Immunohistochemistry (paraffin and frozen sections (5µg/ml))
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Development of hybridomas secreting monoclonal antibodies to the chicken intestinal 1 alpha,25-dihydroxyvitamin D3 receptor:
J.W. Pike, et al.; PNAS
79
, 7719 (1982)
Abstract
Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3. Generation by a preparation enriched in a 64,000-dalton protein:
J.W. Pike, et al.; J. Biol. Chem.
258
, 1289 (1983)
Abstract
;
Full Text
Immunocytochemical localization of the 1,25-dihydroxyvitamin D3 receptor in target cells:
T.L. Clemens, et al.; Endocrinology
122
, 1224 (1988)
Abstract
Molecular biology of the vitamin D hormone:
M.R. Haussler, et al.; Recent Progr. Horm. Res.
44
, 263 (1988)
Abstract
Immunohistochemical detection of 1,25-dihydroxyvitamin D3 receptors and estrogen receptors by monoclonal antibodies: comparison of four immunoperoxidase methods:
P. Milde, et al.; J. Histochem. Cytochem.
37
, 1609 (1989)
Abstract
Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor
:
P.N. MacDonald, et al.; J. Biol. Chem.
266
, 18808 (1991)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-210-108
Revised 24-Feb-05
Polyclonal Antibody to Vitamin D3 Receptor
SYNONYMS
anti-VDR PAb
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-210-108-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 395-413 (E
395
EHSKQYRCLS
FQPECSMK
413
) of C-terminal human VDR (vitamin D
3
receptor).
SPECIFICITY:
Recognizes human, mouse and rat VDR. Detects a band of ~53kDa by Western blot.
APPLICATION:
Gel Supershift Assays
Immunoprecipitation
Western Blot (1:100; For better results we recommend Prod. No.
ALX-804-021
for Western blot applications)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Related Products
ALX-804-021
Monoclonal Antibody to Vitamin D
3
Receptor (9A7)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-460-025
Revised 25-Mar-08
Vitamin D2
SYNONYMS
Calciferol
Ergocalciferol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-025-G001
1 g
33.00 USD
ALX-460-025-G005
5 g
135.00 USD
Product Specification
FORMULA:
C
28
H
44
O
MW:
396.7
CAS NUMBER:
50-14-6
MERCK INDEX:
14:
10018
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Oxidized and inactivated by moisture within a few days.
HANDLING:
Protect from light and moisture. Keep under inert gas.
Further Categories Containing This Product:
Vitamins
ALX-460-026
Revised 25-Mar-08
Vitamin D3
SYNONYMS
Cholecalciferol
Colecalciferol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-026-G001
1 g
23.00 USD
ALX-460-026-G005
5 g
75.00 USD
Product Specification
FORMULA:
C
27
H
44
O
MW:
384.7
CAS NUMBER:
67-97-0
MERCK INDEX:
14:
10019
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Oxidized and inactivated by moisture within a few days.
HANDLING:
Keep under inert gas. Protect from light and moisture.
Further Categories Containing This Product:
Vitamins
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