• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Neurobiology
You are here: Product Lines > Neurobiology
Toolbar - View Selection
 
 Items 20-40 of 1126 Page 2 of 57 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-343 Revised 30-May-07
3-O-Methyl-N-acetyl-D-glucosamine
Add to Clipboard
SYNONYMS 3-OMe-GlcNAc
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-343-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO6
MW: 235.2
CAS NUMBER: 94825-74-8
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or water (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
Product Specific Literature References
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro: R. Zeitler, et al.; Eur. J. Biochem. 204, 1165 (1992) Abstract
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver: I. Miwa, et al.; Enzyme Protein 48, 135 (1994) Abstract
Further Categories Containing This Product:
N-Acetylneuraminic Acid / DerivativesObesity & Diabetes Other Products
 
 
ALX-305-010 Revised 10-Dec-04
N-Acetylneuraminic acid
Add to Clipboard
SYNONYMS NANA
Sialic acid
Neu5Ac
5-Acetylamino-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-305-010-M050   50 mg 30.00 USD Add To Cart
ALX-305-010-M250   250 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C11H19NO9
MW: 309.3
CAS NUMBER: 131-48-6
MERCK INDEX: 14: 8484
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to light pink powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable between pH 4.0 and 7.0 when frozen.
HANDLING: Protect from light.
Further Categories Containing This Product:
N-Acetylneuraminic Acid / Derivatives
 
 
ALX-350-262 Revised 07-Oct-08
Kuanoniamine C
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-262-M001   1 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C21H18N4OS
MW: 374.5
CAS NUMBER: 133401-11-3
SOURCE/HOST: Isolated from the sponge Oceanapia spec.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cytotoxic. Inhibits proliferation of several cell lines. Binds to adenosine receptor subtypes A1 and A2A.
Product Specific Literature References
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp: C. Eder, et al.; J. Nat. Prod. 61, 301 (1998) Abstract
Pyrroloquinoline and pyridoacridine alkaloids from marine sources: Q. Ding, et al.; Curr. Med. Chem. 6, 1 (1999) Abstract
 
 
ALX-480-038 Revised 18-Jun-08
IBMX
Add to Clipboard
SYNONYMS 3-Isobutyl-1-methylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-038-M500   500 mg 99.00 USD Add To Cart
ALX-480-038-G001   1 g 195.00 USD Add To Cart
Product Specification
FORMULA: C10H14N4O2
MW: 222.3
CAS NUMBER: 28822-58-4
RTECS: ZD8500000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or methanol (warm, 50mg/ml); almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by IR.

Product Description
Potent, non-specific inhibitor of phosphodiesterases. More potent than theophylline (Prod. No. ALX-480-062) at adenosine receptors. Accelerates conversion of mouse fibroblast cells into adipose cells.
Product Specific Literature References
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity: J.A. Beavo, et al.; Mol. Pharmacol. 6, 597 (1970) Abstract
Adenosine 3':5'-cyclic monophosphate and insulin release: W. Montague & J.R. Cook; Biochem. J. 120, 9P (1970) Abstract
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans: W. Montague & J.R. Cook; Biochem. J. 122, 115 (1971) Abstract
Cyclic nucleotide phosphodiesterase activity in normal mouse pancreatic islets: S.J. Ashcroft, et al.; FEBS Lett. 20, 263 (1972) Abstract
The mode of action of adenosine 3’:5’-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity: W. Montague & S.L. Howell; Biochem. J. 134, 321 (1973) Abstract
Effects of methylxanthines on adenosine 3’,5’-monophosphate and corticosterone in the rat adrenal: A. Peytremann, et al.; Endocrinology 92, 525 (1973) Abstract
Concentration of adenosine 3’:5’-cyclic monophosphate in mouse pancreatic islets measured by a protein-binding radioassay: R.H. Cooper, et al.; Biochem. J. 134, 599 (1973) Abstract
Determination of theophylline in plasma by electron capture gas chromatography: H.A. Schwertner, et al.; Anal. Chem. 48, 1875 (1976) Abstract
Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation: D.F. Horrobin, et al.; Prostaglandins 13, 33 (1977) Abstract
Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine: G.L. Kramer, et al.; Biochemistry 16, 3316 (1977) Abstract
Cyclic nucleotide phosphodiesterases of human and rat gastric mucosa: U. Klotz, et al.; Naunyn-Schmiedebergs Arch. Pharmacol. 296, 187 (1977) Abstract
Allergic reactions, cyclic AMP and histamine release: P.S. Skov, et al.; Experientia 33, 965 (1977) Abstract
Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures: T.R. Russell; PNAS 76, 4451 (1979) Abstract
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine: P. Janik, et al.; Cancer Res. 40, 1950 (1980) Abstract
Induction of a transient elevation in intracellular levels of adenosine-3’,5’-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation: L. Simchowitz, et al.; J. Immunol. 124, 1482 (1980) Abstract
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia & A.R. Rhoads; Biochem. Pharmacol. 31, 665 (1982) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Methylxanthine inhibitors of phosphodiesterases: J.N. Wells & J.R. Miller; Methods Enzymol. 159, 489 (1988) Abstract
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline: V.L. Coffin and R.D. Spealman; Eur. J. Pharmacol. 170, 35 (1989) Abstract
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium: Y. Katano & M. Endoh; BBRC 167, 123 (1990) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells: F. Scamps, et al.; Eur. J. Pharmacol. 244, 119 (1993) Abstract
Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes, et al.; Cell. Signal. 5, 615 (1993) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
 
 
ALX-480-061 Revised 15-Mar-06
Theobromine
Add to Clipboard
SYNONYMS 3,7-Dimethylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-061-G005   5 g 10.00 USD Add To Cart
ALX-480-061-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C7H8N4O2
MW: 180.2
CAS NUMBER: 83-67-0
MERCK INDEX: 14: 9282
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 0.5M sodium hydroxide; insoluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Weak phosphodiesterase inhibitor and adenosine receptor blocker. Diuretic and smooth-muscle relaxant.
Product Specific Literature References
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines: J.W. Daly, et al.; Cell Mol. Neurobiol. 3, 69 (1983) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
 
 
ALX-480-062 Revised 24-Oct-07
Theophylline
Add to Clipboard
SYNONYMS 1,3-Dimethylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-062-G005   5 g 5.00 USD Add To Cart
ALX-480-062-G025   25 g 15.00 USD Add To Cart
Product Specification
FORMULA: C7H8N4O2
MW: 180.2
CAS NUMBER: 58-55-9
MERCK INDEX: 14: 9285
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous acid, dilute aqueous base or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Cyclic phosphodiesterase inhibitor. Weakly inhibits alkaline phosphodiesterases and 5’-nucleotidase. Muscle relaxant, cardiac stimulant and diuretic. Used for the treatment of asthma.
Product Specific Literature References
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 28, 487 (1985) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Theophylline: new perspectives for an old drug: P.J. Barnes; Am. J. Respir. Crit. Care Med. 167, 813 (2003), (Review) Abstract
 
 
ALX-550-269 Revised 27-Oct-06
8-Cyclopentyl-1,3-dipropylxanthine
Add to Clipboard
SYNONYMS DPCPX
PD 116,948
1,3-Dipropyl-8-cyclopentylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-269-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C16H24N4O2
MW: 304.4
CAS NUMBER: 102146-07-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and very selective A1 adenosine receptor antagonist, both in vitro and in vivo.
Product Specific Literature References
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986) Abstract
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987) Abstract
PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987) Abstract
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989) Abstract
Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994) Abstract
 
 
ALX-620-064 Revised 17-Dec-04
Dansyl-NECA
Add to Clipboard
SYNONYMS 1-Deoxy-1-[6-[[6-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-064-MC05   0.5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C30H40N8O6S
MW: 640.8
CAS NUMBER: 219982-12-4
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Fluorescent ligand for adenosine receptors with a marked selectivity for the A1 receptor subtype. Has been successfully applied in fluorescence microscopy assays.
Product Specific Literature References
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives: M. Macchia, et al.; Bioorg. Med. Chem. Lett. 8, 3223 (1998) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-350-092 Revised 03-Apr-08
Emetine . dihydrochloride
Add to Clipboard
SYNONYMS 6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - DNA Replication Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-092-M050   50 mg 10.00 USD Add To Cart
Product Specification
FORMULA: C29H40N2O4 . 2HCl
MW: 480.7 . 73.0
CAS NUMBER: 316-42-7
MERCK INDEX: 14: 3559
SOURCE/HOST: Isolated from ground roots of Uragoga ipecacuanha.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: TOXIC.

Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968) Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991) Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991) Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995) Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005) Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007) Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007) Abstract
 
 
ALX-350-104 Revised 10-May-07
Aaptamine
Add to Clipboard
SYNONYMS 8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-104-M001   1 mg