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Vitamin D3 & Vitamin D3 Receptor / Related Products
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ALX-460-036 Revised 17-Jan-05
Alfacalcidol
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SYNONYMS Hydroxyvitamin D3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-036-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O2
MW: 400.6
CAS NUMBER: 41294-56-8
RTECS: VS2851000
PURITY: ≥97%
APPEARANCE: White to off white crystals.
SOLUBILITY: Soluble in ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No. ALX-460-032) in vivo. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
 
 
ALX-460-032 Revised 18-Dec-07
Calcitriol
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SYNONYMS Vitamin D3, 1α,25-Dihydroxy-
1α,25-Dihydroxyvitamin D3
1,25(OH)2D3
1α,25-Dihydroxycholecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-032-C100   100 µg 150.00 USD Add To Cart
ALX-460-032-M001   1 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C27H44O3
MW: 416.7
CAS NUMBER: 32222-06-3
MERCK INDEX: 14: 1644
RTECS: FZ4645000
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Slightly soluble in methanol, 100% ethanol, ethyl acetate or tetrahydrofuran. 
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Osteotropic hormone that up-regulates RANKL level and down-regulates OPG level. Biologically active form of vitamin D3 in intestinal calcium transport and bone calcium resorption.
Product Specific Literature References
A rapidly acting metabolite of vitamin D3: Haussler, et al.; PNAS 68, 177 (1971) Abstract
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture: Raisz, et al.; Science 175, 768 (1972) Abstract
Further Categories Containing This Product:
Vitamins
 
 
ALX-804-021 Revised 21-Jul-08
Monoclonal Antibody to Vitamin D3 Receptor (9A7)
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SYNONYMS anti-VDR MAb (9A7)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-021-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 9A7
ISOTYPE: Rat IgG2b
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody containing 0.05% sodium azide.
IMMUNOGEN: Partially purified chicken intestinal cytoplasmic VDR (vitamin D3 receptor).
SPECIFICITY: Recognizes the occupied and unoccupied forms of VDR in human, mouse, rat, hamster, chicken, amphibian and fish. Recognizes an epitope between aa 89 and 105 of human VDR. In avians detects bands of ~58kDa and ~60kDa by Western blot, while in mammalian species the VDRs appear as a single band within the ~52-55kDa range.
Does not cross-react with ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION: Gel Supershift Assays
Immunocytochemistry
Immunohistochemistry (paraffin and frozen sections (5µg/ml))
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Development of hybridomas secreting monoclonal antibodies to the chicken intestinal 1 alpha,25-dihydroxyvitamin D3 receptor: J.W. Pike, et al.; PNAS 79, 7719 (1982) Abstract
Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3. Generation by a preparation enriched in a 64,000-dalton protein: J.W. Pike, et al.; J. Biol. Chem. 258, 1289 (1983) Abstract; Full Text
Immunocytochemical localization of the 1,25-dihydroxyvitamin D3 receptor in target cells: T.L. Clemens, et al.; Endocrinology 122, 1224 (1988) Abstract
Molecular biology of the vitamin D hormone: M.R. Haussler, et al.; Recent Progr. Horm. Res. 44, 263 (1988) Abstract
Immunohistochemical detection of 1,25-dihydroxyvitamin D3 receptors and estrogen receptors by monoclonal antibodies: comparison of four immunoperoxidase methods: P. Milde, et al.; J. Histochem. Cytochem. 37, 1609 (1989) Abstract
Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor: P.N. MacDonald, et al.; J. Biol. Chem. 266, 18808 (1991) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-108 Revised 24-Feb-05
Polyclonal Antibody to Vitamin D3 Receptor
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SYNONYMS anti-VDR PAb
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
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ALX-210-108-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 395-413 (E395EHSKQYRCLS
FQPECSMK413) of C-terminal human VDR (vitamin D3 receptor).
SPECIFICITY: Recognizes human, mouse and rat VDR. Detects a band of ~53kDa by Western blot.
APPLICATION: Gel Supershift Assays
Immunoprecipitation
Western Blot (1:100; For better results we recommend Prod. No. ALX-804-021 for Western blot applications)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-460-025 Revised 25-Mar-08
Vitamin D2
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SYNONYMS Calciferol
Ergocalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-025-G001   1 g 33.00 USD Add To Cart
ALX-460-025-G005   5 g 135.00 USD Add To Cart
Product Specification
FORMULA: C28H44O
MW: 396.7
CAS NUMBER: 50-14-6
MERCK INDEX: 14: 10018
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Oxidized and inactivated by moisture within a few days.
HANDLING: Protect from light and moisture. Keep under inert gas.

Further Categories Containing This Product:
Vitamins
 
 
ALX-460-026 Revised 25-Mar-08
Vitamin D3
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SYNONYMS Cholecalciferol
Colecalciferol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-026-G001   1 g 23.00 USD Add To Cart
ALX-460-026-G005   5 g 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O
MW: 384.7
CAS NUMBER: 67-97-0
MERCK INDEX: 14: 10019
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in 100% ethanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Oxidized and inactivated by moisture within a few days.
HANDLING: Keep under inert gas. Protect from light and moisture.

Further Categories Containing This Product:
Vitamins
 
 
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