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Cytoskeleton
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ALX-803-309 Revised 17-Mar-08
Monoclonal Antibody to Collagen Type XII (378D5)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Collagen / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-309-R100   100 µl 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 378D5
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites.
IMMUNOGEN: Collagen type XII purified from bovine kidney.
SPECIFICITY: Recognizes human, mouse, rat, bovine and chicken collagen type XII.
APPLICATION: ELISA (1:500-1:1’000)
Immunohistochemistry (1:500-1:1’000): A mild trypsin- or Protease 27 (Sigma)-digestion (0.05% for 10-15min at 37°C) or alternatively microwave oven treatment is recommended to unmask the collagens. Not recommended for paraffin sections.
Immunoprecipitation (1:50-1:100)
Western Blot (1:100-1:300)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-314 Revised 10-Apr-08
Monoclonal Antibody to COMP (484D1)
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SYNONYMS anti-Cartilage Oligomeric Matrix Protein MAb (484D1)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cytoskeleton & Extracellular Matrix Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-314-R100   100 µl 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
CLONE: 484D1
ISOTYPE: Rat IgG1
FORMULATION: Liquid. Ascites.
IMMUNOGEN: Human COMP (cartilage oligomeric matrix protein).
SPECIFICITY: Recognizes human, rat and bovine COMP.
APPLICATION: ELISA (1:500-1:2'000)
Immunohistochemistry (frozen sections (1:100-1:300))
Immunoprecipitation (1:100-1:300)
Western Blot (1:100-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts: P.E. Di Cesare, et al.; J. Orthop. Res. 18, 713 (2000) Abstract
Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin: P.E. Di Cesare, et al.; Matrix Biol. 21, 461 (2002) Abstract
General Information
COMP (cartilage oligomeric matrix protein is a tissue-specific non-collagenous protein that was shown to be an important biomarker for inflammatory diseases. Mutations in the gene encoding COMP cause two common skeletal dysplasias, pseudoachondroplasia (PSACH) and mutiple epiphyseal dysplasia (MED).
General Literature References
Characterization of human and mouse cartilage oligomeric matrix protein: G. Newton, et al.; Genomics 24, 435 (1994) Abstract
Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments: G. Morozzi, et al.; Ann. N.Y. Acad. Sci. 1108, 398 (2007) Abstract
Further Categories Containing This Product:
Inflammation Other Products • Bone Metabolism Other Products • Monoclonal Antibodies
 
 
ALX-804-640 Revised 27-Mar-08
Monoclonal Antibody to Cytokeratin 18 (human) (M5)
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SYNONYMS anti-CK18 (human) MAb (M5)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytokeratin-based Apoptosis Detection
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-640-T200   200 tests 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: M5
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. In PBS containing 0.1% BSA, PEG, sucrose and 0.09% sodium azide.
IMMUNOGEN: CK18 (cytokeratin 18) fragments purified from human carcinomas.
SPECIFICITY: Recognizes an internal, formalin-resistant epitope (aa 284-396) present on uncleaved as well as caspase-cleaved human CK18 fragments.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation
Western Blot
Note: A dilution of 1:100 in incubation buffer is generally recommended. Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION For more information on procedures please also see the Original Manufacturer’s Product Description (click here to download pdf).
MANUFACTURER Manufactured by Peviva AB.
General Literature References
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18: G. Kramer, et al.; Cancer Res. 64, 1751 (2004) Abstract; Full Text
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles: G. Kramer, et al.; Br. J. Cancer 94, 1592 (2006) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies • Keratins / Related Products • Tumor Markers
 
 
ALX-804-641 Revised 27-Mar-08
Monoclonal Antibody to Cytokeratin 18 (M6)
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SYNONYMS anti-CK18 MAb (M6)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytokeratin-based Apoptosis Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-641-T200   200 tests 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE: M6
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.1mg/ml
FORMULATION: Liquid. In PBS containing 0.1% BSA, PEG, sucrose and 0.09% sodium azide.
IMMUNOGEN: CK18 (cytokeratin 18) fragments purified from human carcinomas.
SPECIFICITY: Recognizes an internal, formalin-resistant epitope (aa 284-396) present on uncleaved as well as caspase-cleaved human, mouse, rat and dog CK18 fragments.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation
Western Blot
Note: A dilution of 1:200 in incubation buffer is generally recommended. Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION For more information on procedures please also see the Original Manufacturer’s Product Description (click here to download pdf).
MANUFACTURER Manufactured by Peviva AB.
General Literature References
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18: G. Kramer, et al.; Cancer Res. 64, 1715 (2004) Abstract; Full Text
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles: G. Kramer, et al.; Br. J. Cancer 94, 1592 (2006) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies • Keratins / Related Products • Tumor Markers
 
 
ALX-803-317 Revised 26-Mar-08
Monoclonal Antibody to Decorin (889C7)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Proteoglycans / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-317-R100   100 µl 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
CLONE: 889C7
ISOTYPE: Mouse IgG2a
FORMULATION: Liquid. Ascites.
IMMUNOGEN: Bovine skin decorin (chondroitinase ABC-digested).
SPECIFICITY: Recognizes human and bovine skin decorin.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-340 Revised 18-Sep-07
Monoclonal Antibody to DLC1 (10D6)
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SYNONYMS anti-Dynein Light Chain 1 MAb (10D6)
anti-LC8 MAb (10D6)
anti-Protein Inhibitor of nNOS MAb (10D6)
anti-PIN MAb (10D6)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
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ALX-804-340-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 10D6
ISOTYPE: Rat IgM
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS containing 10mM sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1. Does not cross-react with DLC2.
For detection of both DLC1 and DLC2 see MAb to DLC1 and DLC2 (11F7) (Prod. No. ALX-804-341).
APPLICATION: Flow Cytometry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells: Y. Zhu, et al.; PNAS 101, 7681 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-341 Revised 05-Mar-07
Monoclonal Antibody to DLC1 and DLC2 (11F7)
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SYNONYMS anti-Dynein Light Chain 1/2 MAb (11F7)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-341-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 11F7
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1 and DLC2.
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Interaction of the postsynaptic density-95/guanylate kinase domain- associated protein complex with a light chain of myosin-V and dynein: S. Naisbitt, et al.; J. Neurosci. 20, 4524 (2000) Abstract; Full Text
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-263 Revised 18-Aug-05
Monoclonal Antibody to E-cadherin (mouse) (ECCD-1)
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SYNONYMS anti-Uvomorulin (mouse) MAb (ECCD-1)
anti-CD324 (mouse) MAb (ECCD-1)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Antibodies
Ordering Information
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ALX-804-263-C100   100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: ECCD-1
ISOTYPE: Rat IgG2b
SOURCE/HOST: Obtained by fusing the P3-X63-Ag8-U1 myeloma cell line with splenocytes of Wistar rat immunized with mouse teratocarcinoma cell line F9. Purified from serum-free cell culture supernatant.
CONCENTRATION: 2mg/ml after reconstitiution.
FORMULATION: Lyophilized from ascites, dissolved in 10mM PBS, pH 7.4, containing 1.0% BSA.
RECONSTITUTION: Reconstitute with 50µl distilled water. Dilute with 20mM TBS, pH 7.4, 10mM CaCl2, 1.0% BSA. Reconstituted solution should contain 0.1% sodium azide as a preservative when stored at +4°C.
IMMUNOGEN: Mouse teratocarcinoma cell line F9.
SPECIFICITY: Recognizes mouse E-cadherin. Epitope is close to the N-terminus of E-cadherin. Does not cross-react with human, bovine, chicken or dog E-cadherin.
APPLICATION: Functional Application: Inhibits E-cadherin-dependent cell-cell contact (200µg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody: C. Yoshida-Noro, et al.; Dev. Biol. 101, 19 (1984) Abstract
Transformation of cell adhesion properties by exogenously introduced E- cadherin cDNA: A. Nagafuchi, et al.; Nature 329, 341 (1987) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Ca2+ should be contained in all the buffers to stabilize cadherin antigen.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-330 Revised 11-Nov-08
Monoclonal Antibody to EpCAM (human) (VU-1D9)
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SYNONYMS anti-Epithelial Specific Antigen (human) MAb (VU-1D9)
anti-ESA (human) MAb (VU-1D9)
anti-Epithelial Cell Adhesion Molecule (human) MAb (VU-1D9)
anti-CD326 (human) MAb (VU-1D9)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Adhesion Molecules & Receptors Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-330-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: VU-1D9
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Small cell lung carcinoma cells.
SPECIFICITY: Recognizes human EpCAM (epithelial specific antigen), a 40 kDa epithelial protein expressed on baso-lateral cell surface in many epithelial tissues (but absent from mesothelial tissue). Differentiates between mesothelioma and carcinoma.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections, paraffin sections (microwave treatment not necessary))
Immunoprecipitation
Western Blot
Functional Application (blocking)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-803-308 Revised 17-Mar-08
Monoclonal Antibody to Fibromodulin (human) (630D1)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Proteoglycans / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-308-L010   10 ml 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 630D1
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Hybridoma supernatant.
IMMUNOGEN: Human fibromodulin purified from tendon.
SPECIFICITY: Recognizes human fibromodulin.
APPLICATION: ELISA (1:500-1:1'000)
Immunohistochemistry (frozen sections (1:100-1:200))
Western Blot (1:500-1:1'000; non-reducing conditions)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-622 Revised 23-Apr-08
Monoclonal Antibody to Fibulin-1 (human) (MEM-2)
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