ALEXIS Biochemicals: Ristocetin A . sulfate

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ALX-307-001

Revised 18-Feb-08

L-Quebrachitol
SYNONYMS	1L-2-O-Methyl-chiro-inositol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-307-001-G001		1 g	40.00 USD

Product Specification

FORMULA:	C₇H₁₄O₆
MW:	194.2
CAS NUMBER:	642-38-6
SOURCE/HOST:	Isolated from rubber tree.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Key starting material for the synthesis of optically active inositol phosphates.

Product Specific Literature References

Synthesis of 1D-3-deoxy-, 1D-2,3-dideoxy-, and 1D-2,3,6-trideoxy-myo-inositol 1,4,5-trisphosphate from quebrachitol, their binding affinities, and calcium release activity: A.P. Kozikowski, et al.; JACS 115, 4429 (1993)
Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-Chloro-3-deoxy Analogs of Phosphatidylinositol: A.P. Kozikowski, et al.; J. Org. Chem. 59, 963 (1994)
Quebrachitol: A Versatile Building Block in the Construction of Naturally
Occurring Bioactive Materials: J.J. Kiddle; Chem. Rev. 95, 2189 (1995), (Review) Abstract
A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol: L. Qiao, et al.; Org. Lett. 2, 115 (2000) Abstract

Further Categories Containing This Product:

Chiral Compounds (Organic) • Chemical Synthesis - Reagents & Intermediates • Inositols & Inositolphosphates / Related Products

ALX-380-237

Revised 28-Feb-08

Ristocetin A . sulfate
SYNONYMS	Ristocetin . sulfate Ristomycin III . sulfate Spontin . sulfate Riston . sulfate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-237-M010		10 mg	220.00 USD

Product Specification

FORMULA:	C₉₅H₁₁₀N₈O₄₄. H₂SO₄
MW:	2067.9 . 98.0
CAS NUMBER:	11140-99-1
MERCK INDEX:	14: 8234
RTECS:	VJ8595000
SOURCE/HOST:	Isolated from Amycolatopsis sp. MST-AS5924.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.

Product Specific Literature References

Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957)
Ristocetin--a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh. 26, 362 (1971) Abstract
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol. 3, 207 (1996) Abstract; Full Text
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost. 1, 2636 (2003) Abstract
HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci. 29, 1305 (2006), (Review) Abstract

Further Categories Containing This Product:

Chiral Compounds (Organic) • Coagulation Factors / Related Products

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