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Bone Metabolism
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ALX-350-116 Revised 29-Nov-07
Sauchinone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-116-M001   1 mg 70.00 USD Add To Cart
ALX-350-116-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C20H20O6
MW: 356.4
SOURCE/HOST: Isolated from Saururus chinensis.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
Product Specific Literature References
Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000) Abstract
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000) Abstract
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003) Abstract
Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Bone Metabolism Other Products • NF-kB Pathway Inhibitors
 
 
ALX-350-147 Revised 03-Oct-07
Bavachin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-147-MC05   0.5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 19879-32-4
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • Estrogen & Estrogen Receptors / Related Products • Flavanones • Bone Metabolism Other Products
 
 
ALX-350-328 Revised 07-Apr-08
(+)-Madindoline A
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SYNONYMS MadA
MDL-A
[(2R), 3aR, 8aS]-8-[4-(n-Butyl)-2,5-dimethyl-1, 3-dioxo-2-(4-cyclopentyl)methyl]-3, 3a, 8,8a-tetrahydro-3a-hydroxy-2H-furo[2,3-b] indole
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin & Interleukin Receptors Other Products
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ALX-350-328-MC05   0.5 mg 330.00 USD Add To Cart
ALX-350-328-M001   1 mg 580.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO4
MW: 370.2
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Light yellow needles
SOLUBILITY: Soluble in methanol or 100% ethanol; insoluble in hexane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Madindolines are noncytotoxic indole alkaloids originally isolated from a fermentation broth of Streptomyces nitrosporeus K93-071. (+)-Madindoline A (MadA; MDL-A) and (+)-madindoline B (MadB; MDL-B) are diastereomers with MadA being the more potent compound. MadA binds competitively but noncovalently to the extracellular domain of the membrane glycoprotein gp130 and inhibits the homodimerization of the trimeric IL-6/IL-6R/gp130 or the IL-11/gp130 complex, thus inhibiting activation of the JAK/STAT signal transduction pathway. MadA inhibits IL-6 and IL-11-induced osteoclastogenesis in vitro in a dose dependent manner and postmenopausal osteoporosis in vivo, by a mechanism different from that of 17β-estradiol. IL-6 activity is known to cause various diseases such as cancer cachexia, Castleman’s disease, Crohn’s disease, rheumatoid arthritis, hypercalcemia, and multiple myeloma. Madindolines are no longer available from natural sources due to mutation of the originating bacterial strain. Thus, synthetic routes have been developed to produce madindolines. Recently analogs of madindolines have been synthesized as potent IL-6 inhibitors.
Product Specific Literature References
Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities: M. Hayashi, et al.; J. Antibiot. 49, 1091 (1996) Abstract
Madindolines, novel inhibitors of IL-6 activity from streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation: S.Takamatsu, et. al.; J. Antibiot. 50, 1069 (1997) Abstract
Binding of madindoline A to the extracellular domain of gp130: A.Z. Saleh, et al.; Biochemistry 44, 10822 (2005) Abstract
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130: C. Lutticken, et al.; Science 263, 89 (1994) Abstract
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130: M. Hayashi, et al.; PNAS 99, 14728 (2002) Abstract
Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor: G. Strassmann, et.al.; J. Immunol. 150, 2341 (1993) Abstract
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease: K. Yoshizaki, et al.; Blood 74, 1360 (1989) Abstract
Inhibition of IL-6 for the treatment of inflammatory diseases: N. Nishimoto & T. Kishimoto; Curr. Opin. Pharmacol. 4, 386 (2004) Abstract
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis: N. Takagi, et al.; Arthritis Rheum. 41, 2117 (1998) Abstract
Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo: J. de la Mata, et al.; J. Clin. Invest. 95, 2846 (1995) Abstract
Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells: X.G. Zhang, et al.; Blood 76, 2599 (1990) Abstract
Synthesis of (+)-madindoline A and (+)-madindoline B: L. Wan & M.A. Tius; Org. Lett. 9, 647 (2007) Abstract
Design, synthesis, and biological activities of madindoline analogues: D. Yamamoto, et al.; Bioorg. Med. Chem. Lett. 16, 2807 (2006) Abstract
Efficient total synthesis of novel bioactive microbial metabolites: T. Sunazuka, et al.; Acc. Chem. Res. 41, 302 (2008) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Alkaloids • Bone Metabolism Other Products
 
 
ALX-380-066 Revised 07-Apr-08
Kendomycin
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SYNONYMS (-)-TAN 2162
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-066-C100   100 µg 95.00 USD Add To Cart
ALX-380-066-C500   500 µg 370.00 USD Add To Cart
Product Specification
FORMULA: C29H42O6
MW: 486.6
CAS NUMBER: 59785-91-0
SOURCE/HOST: Isolated from Streptomyces violaceoruber.
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Potent endothelin receptor antagonist. Anti-osteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.
Product Specific Literature References
2000 Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: A.Zeeck & H.B. Bode; J. Chem. Soc. Perkin Trans. 323 (2000)
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; Chembiochem. 8, 1261 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Other Signal Transduction Pathway Modulators • Endothelins [ETs] & Endothelin Receptors / Related Products • Antibiotics - Proteasome / Ubiquitin Modulators • Bone Metabolism Other Products
 
 
ALX-380-203 Revised 27-Jun-08
Ansatrienin A
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SYNONYMS Mycotrienin I
T 23I
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-203-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C36H48N2O8
MW: 636.8
CAS NUMBER: 82189-03-5
RTECS: AY4553220
SOURCE/HOST: Isolated from Streptomyces collinus.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antitumor antibiotic, closely related to the cytotrienins. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
 
 
ALX-380-204 Revised 17-Jun-08
Ansatrienin B
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SYNONYMS Mycotrienin II
T 23II
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-204-M001   1 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C36H50N2O8
MW: 638.8
CAS NUMBER: 82189-04-6
RTECS: AY4553430
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5998.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antitumor antibiotic, closely related to the cytotrienins. Displays potent anticancer activities. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
 
 
ALX-380-209 Revised 13-Nov-07
Bafilomycin C1
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SYNONYMS L-681,110A1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-209-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C39H60O12
MW: 720.4
CAS NUMBER: 88979-61-7
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5338.
PURITY: ≥95% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide oder DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Abstract
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Abstract
Further Categories Containing This Product:
H+-ATPase / Related Products • Antibiotics - Antifungal • Bone Metabolism Other Products
 
 
ALX-380-216 Revised 20-Jun-08
Reveromycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-216-MC01   0.1 mg 150.00 USD Add To Cart
ALX-380-216-MC25   0.25 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: 134615-37-5
FORMULA: C36H52O11
MW: 660.8
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5344.
PURITY: ≥99% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in acidic conditions.

Product Description
Antibiotic. Dominant analog of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Displays antiproliferative as well as potent antifungal activity. Induces apoptosis in osteoclasts thus inhibiting bone resorption.
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1409 (1992) Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities: H. Takahashi, et al.; J. Antibiot. (Tokyo) 45, 1414 (1992) Abstract
Chemical modification of reveromycin A and its biological activities: T. Shimizu, et al.; Bioorg. Med. Chem. Lett. 12, 3363 (2002) Abstract
Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A: Y. Miyamoto, et al.; J. Biol. Chem. 277, 28810 (2002) Abstract; Full Text
Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity: H. Muguruma, et al.; Clin. Cancer Res. 11, 8822 (2005) Abstract; Full Text
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts: J.T. Woo, et al.; PNAS 103, 4729 (2006) Abstract; Full Text
Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone: S. Sone and S. Yano; Cancer Metastasis Rev. 26, 685 (2007) Abstract
Regulation of osteoclast polarization: N. Takahashi, et al.; Odontology 95, 1 (2007), (Review) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Antibiotics - Antifungal • Cell Cycle Blockers & Inhibitors / Related Products • EGFR Kinase Inhibitors • Bone Metabolism Other Products
 
 
ALX-380-217 Revised 08-Apr-08
Reveromycin B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-217-MC25   0.25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C36H52O11
MW: 660.8
CAS NUMBER: 144860-68-4
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5344.
PURITY: ≥90% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in acidic conditions.

Product Description
Antibiotic. Much less active analog of reveromycin A (Prod. No. ALX-380-216), which is a G1 phase cell cycle inhibitor and induces apoptosis in osteoclasts. Useful negative control in resolving the mode of action of this class.