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Items 8 of 8
ALX-158-011
Revised 12-Sep-05
Humanin (human)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Alzheimer Research Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-158-011-MC05
0.5 mg
210.00 USD
ALX-158-011-M001
1 mg
350.00 USD
Product Specification
SEQUENCE:
H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
FORMULA:
C
119
H
204
N
34
O
32
S
2
MW:
2687.3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein [1]. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function [1-3]. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin [4]. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release
in vitro
.
Product Specific Literature References
[1]
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta:
Y. Hashimoto, et al.; PNAS
98
, 6336 (2001)
Abstract
;
Full Text
[2]
Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults
:
Y. Hashimoto, et al.; J. Neurosci.
21
, 9235 (2001)
Abstract
;
Full Text
[3]
Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein
:
Y. Hashimoto, et al.; BBRC
283
, 460 (2001)
Abstract
[4]
Humanin peptide suppresses apoptosis by interfering with Bax activation
:
B. Guo, et al.; Nature
423
, 456 (2003)
Abstract
Further Categories Containing This Product:
Peptides
•
Bcl-2 Family Interacting Proteins / Related Products
ALX-803-323
Revised 27-May-08
Monoclonal Antibody to BAG-3 (AC-1)
SYNONYMS
anti-Bcl-2-binding Athanogene-3 MAb (AC-1)
anti-Docking Protein CAIR-1 MAb (AC-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-323-C100
100 µg
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
AC-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 18-33 (D
18
RDPLPPGWEIKIDPQ
33
) of N-terminal human BAG-3 (Bcl-2-binding athanogene 3).
SPECIFICITY:
Recognizes human, mouse and rat BAG-3.
APPLICATION:
ELISA
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Bag3 gene expression is regulated by heat shock factor 1:
S. Franceschelli, et al.; J. Cell Physiol.
215
, 575 (2008)
Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.
General Literature References
BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis:
M.F. Romano, et al.; Cell Death Differ.
10
, 383 (2003)
Abstract
;
Full Text
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein:
A. Rosati, et al.; Int. J. Biochem. Cell Biol.
39
, 1337 (2007)
Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Monoclonal Antibodies
ALX-804-367
Revised 04-Nov-08
Monoclonal Antibody to Bif-1 (human) (30A882.1.1)
SYNONYMS
anti-Bax Interacting Factor-1 (human) MAb (30A882.1.1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-367-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
30A882.1.1
ISOTYPE:
Mouse IgG
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Bif-1 (Bax interacting factor-1).
SPECIFICITY:
Recognizes human Bif-1.
APPLICATION:
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax:
S.M. Cuddeback, et al.; J. Biol. Chem.
276
, 20559 (2001)
Abstract
;
Full Text
Endophilin B1 is required for the maintenance of mitochondrial morphology:
M. Karbowski, et al.; J. Cell Biol.
166
, 1027 (2004)
Abstract
General Literature References
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis:
Y. Takahashi, et al.; Nat. Cell Biol.
9
, 1142 (2007)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
•
Autophagy Other Products
ALX-210-011
Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (Bur 1680)
SYNONYMS
anti-Bcl-2 Associated Athanogene-1 PAb (Bur 1680)
anti-BAG Family Molecular Chaperone Regulator 1 (Bur 1680) PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-011-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant mouse BAG-1 (Bcl-2 associated athanogene-1) (aa 8-219).
SPECIFICITY:
Recognizes mouse and rat BAG-1.
APPLICATION:
Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections (1:5'000))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Bag1 is a regulator and marker of neuronal differentiation:
P. Kermer, et al.; Cell Death Differ.
9
, 405 (2002)
Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions:
S. Alberti, et al.; Cell Stress Chaperones
8
, 225 (2003)
Abstract
;
Full Text
BAG-1: a multi-functional pro-survival molecule:
P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol.
37
, 251 (2005)
Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Chaperone-mediated Autophagy [CMA]
•
Polyclonal Antibodies
•
Ubiquitin Ligases [E3]
ALX-210-009
Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (mouse) (CT) (Bur 1702)
SYNONYMS
anti-Bcl-2 Associated Athanogene-1 (mouse) (CT) PAb (Bur 1702)
anti-BAG Family Molecular Chaperone Regulator 1 (mouse) (CT) (Bur 1702) PAb
anti-RAP46 (mouse) (CT) (Bur 1702) PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-009-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 204-219 (C
204
QETERLQSTNLALAE
219
) of mouse BAG-1 (Bcl-2 associated athanogene-1).
SPECIFICITY:
Recognizes mouse BAG-1.
APPLICATION:
Immunohistochemistry (paraffin sections (1:2'500))
Immunoprecipitation (transfected cells)
Western Blot (1:500-1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
:
S. Takayama, et al.; Cell
80
, 279 (1995)
Abstract
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain
:
M. Adachi, et al.; Blood
88
, 4118 (1996)
Abstract
;
Full Text
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
:
H.G. Wang, et al.; PNAS
93
, 7063 (1996)
Abstract
;
Full Text
Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2
:
C.V. Clevenger, et al.; Mol. Endocrinol.
11
, 608 (1997)
Abstract
;
Full Text
Bag1 is a regulator and marker of neuronal differentiation
:
P. Kermer, et al.; Cell Death Differ.
9
, 405 (2002)
Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions:
S. Alberti, et al.; Cell Stress Chaperones
8
, 225 (2003)
Abstract
;
Full Text
BAG-1: a multi-functional pro-survival molecule:
P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol.
37
, 251 (2005)
Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Chaperone-mediated Autophagy [CMA]
•
Polyclonal Antibodies
•
Ubiquitin Ligases [E3]
ALX-210-010
Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (NT) (Bur 1735)
SYNONYMS
anti-Bcl-2 Associated Athanogene-1 (NT) PAb (Bur 1735)
anti-BAG-family Molecular Chaperone Regulator 1 (NT) (Bur 1735) PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-010-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 26-46 (N
26
ERYDLLVTPQQGNSEPVVQD
46
) of mouse BAG-1 (Bcl-2 associated athanogene-1).
SPECIFICITY:
Recognizes mouse and rat BAG-1.
APPLICATION:
Immunocytochemistry (1:1'000)
Immunohistochemistry (paraffin sections (1:3'500))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Bag1 is a regulator and marker of neuronal differentiation
:
P. Kermer, et al.; Cell Death Differ.
9
, 405 (2002)
Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions:
S. Alberti, et al.; Cell Stress Chaperones
8
, 225 (2003)
Abstract
;
Full Text
BAG-1: a multi-functional pro-survival molecule:
P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol.
37
, 251 (2005)
Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Chaperone-mediated Autophagy [CMA]
•
Polyclonal Antibodies
•
Ubiquitin Ligases [E3]
ALX-210-538
Revised 22-Apr-08
Polyclonal Antibody to BAG-3 (TOS-2)
SYNONYMS
anti-Bcl-2-binding Athanogene-3 PAb (TOS-2)
anti-Docking Protein CAIR-1 PAb (TOS-2)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-538-R050
50 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human BAG-3 (Bcl-2-binding athanogene-3).
SPECIFICITY:
Recognizes human, mouse and rat BAG-3.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections; paraffin sections (1:100-1:200))
Immunoprecipitation
Western Blot (1:1’000-1:2’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Specific Literature References
The anti- apoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor- related apoptosis-inducing ligand (TRAIL):
G. Chiappetta, et al.; J. Clin. Endocrinol. Metab.
92
, 1159 (2007)
Abstract
;
Full Text
Evidence for BAG3 modulation of HIV-1 gene transcription:
A. Rosati, et al.; J. Cell. Physiol.
210
, 676 (2007)
Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.
General Literature References
BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis:
M.F. Romano, et al.; Cell Death Differ.
10
, 383 (2003)
Abstract
;
Full Text
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein:
A. Rosati, et al.; Int. J. Biochem. Cell Biol.
39
, 1337 (2007), (Review)
Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-016
Revised 02-Feb-07
Polyclonal Antibody to BAR (human) (AR-48)
SYNONYMS
anti-Bifunctional Apoptosis Regulator (human) PAb (AR-48)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-016-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains PBS and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human BAR (bifunctional apoptosis regulator) (aa 1-139).
SPECIFICITY:
Recognizes human BAR.
APPLICATION:
Immunocytochemistry (1:1'000)
Immunohistochemistry (paraffin sections (1:3'000))
Western Blot (1:3'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
:
H. Zhang, et al.; PNAS
97
, 2597 (2000)
Abstract
;
Full Text
Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways
:
W. Roth, et al.; Cell Death Differ.
10
, 1178 (2003)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
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