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ALX-350-021 Revised 05-Apr-08
Esculin . hydrate
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SYNONYMS 6,7-Dihydroxycoumarin 6-glucoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-021-G005   5 g 25.00 USD Add To Cart
Product Specification
FORMULA: C15H16O9 . H2O
MW: 340.3 . 18.0
CAS NUMBER: 531-75-9
MERCK INDEX: 14: 3698
RTECS: DJ3085000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant used as a skin protectant. Shows vitamin P activity. Protects cells against DNA damage. Reduces ROS levels. Inhibits carcinogenesis.
Product Specific Literature References
HPLC Analysis of Esculin and Fraxin in Horse-Chestnut Bark (Aesculus hippocastanum L.): G. Stanic, et al.; Croatica Chemica Acta 72, 827 (1999) Full Text
Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin: T. Kaneko, et al.; Biol. Pharm. Bull. 26, 840 (2003) Abstract
Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves: S.H. Duncan, et al.; Br. J. Nutr. 91, 749 (2004) Abstract
Inhibitory effect of esculin on oxidative DNA damage and carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine in hamster pancreas: T. Kaneko, et al.; Biofactors 22, 83 (2004) Abstract
Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line: D.L. Zhao, et al.; Neuropharmacology 53, 724 (2007) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents
 
 
ALX-270-209 Revised 05-Apr-08
Etoposide
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SYNONYMS 4-Desmethylepipodophyllotoxin 9-(4,6-O-ethylidene)-β-D-glucopyranoside
VP-16-213
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Topoisomerase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-209-M025   25 mg 30.00 USD Add To Cart
ALX-270-209-M100   100 mg 65.00 USD Add To Cart
ALX-270-209-M500   500 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H32O13
MW: 588.6
CAS NUMBER: 33419-42-0
MERCK INDEX: 14: 3886
RTECS: KC0190000
SOURCE/HOST: Semisynthetic derivative of podophyllotoxin.
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, ethyl ether or chloroform:methanol (1:1); slightly soluble in methanol or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
HANDLING: Protect from light and moisture.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description
Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.
Product Specific Literature References
The podophyllotoxin derivatives VP16-213 and VM26: B.F. Issell; Cancer Chemother. Pharmacol. 7, 73 (1982) Abstract
Etoposide: four decades of development of a topoisomerase II inhibitor: K.R. Hande; Eur. J. Cancer 34, 1514 (1998) Abstract
Etoposide sensitivity of human prostatic cancer cell lines PC-3, DU 145 and LNCaP: M. Salido, et al.; Histol. Histopathol. 14, 125 (1999) Abstract
A systematic review of the role of etoposide and cisplatin in the chemotherapy of small cell lung cancer with methodology assessment and meta-analysis: C. Mascaux, et al.; Lung Cancer 30, 23 (2000) Abstract
Distinct pathways for stimulation of cytochrome c release by etoposide: J.D. Robertson, et al.; J. Biol. Chem. 275, 32438 (2000) Abstract; Full Text
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells: M. Sawada, et al.; Cell Death Differ. 7, 761 (2000) Abstract
Etoposide-induced apoptosis is not associated with the fas pathway in acute myeloblastic leukemia cells: T. Siitonen, et al.; Leuk. Res. 24, 281 (2000) Abstract
Early caspase activation in leukemic cells subject to etoposide-induced G2-M arrest: evidence of commitment to apoptosis rather than mitotic cell death: R.J. Sleiman & B.W. Stewart; Clin. Cancer Res. 6, 3756 (2000) Abstract; Full Text
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin- dependent enzymes: M. Aoyama, et al.; Biochem Pharmacol 61, 49 (2001) Abstract
Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis: C.A. Johnson, et al.; J. Biol. Chem. 276, 4539 (2001) Abstract; Full Text
In vitro topo II-DNA complex accumulation and cytotoxicity of etoposide in leukaemic cells from patients with acute myelogenous and chronic lymphocytic leukaemia: Y. Wang, et al.; Leuk. Res. 25, 133 (2001) Abstract
Etoposide: discovery and medicinal chemistry: P. Meresse, et al.; Curr. Med. Chem. 11, 2443 (2004), Review Abstract
Etoposide, topoisomerase II and cancer: E.L. Baldwin & N. Osheroff; Curr. Med. Chem. Anticancer Agents 5, 363 (2005), Review Abstract
Further Categories Containing This Product:
Other Toxins • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-350-123 Revised 25-Apr-08
Eugenol (high purity)
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SYNONYMS 2-Methoxy-4-(2-propenyl)phenol (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-123-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C10H12O2
MW: 164.2
CAS NUMBER: 97-53-0
MERCK INDEX: 14: 3898
RTECS: SJ4375000
SOURCE/HOST: Isolated from clove oil, nutmeg, cinnamon and bay leaf.
APPEARANCE: Colorless to pale yellow liquid.
SOLUBILITY: Soluble in 100% ethanol, ether, oils; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: PROTECT FROM AIR!
HAZARD: HARMFUL. MAY BE CARCINOGENIC.

Product Description
TRPV1 agonist. Analgesic. Has antifungal, antimicrobial and antioxidant properties.
Product Specific Literature References
Activation of vanilloid receptor 1 (VR1) by eugenol: B.H. Yang, et al.; J. Dent. Res. 82, 781 (2003) Abstract
Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo: N. Chami, et al.; Oral. Microbiol. Immunol. 20, 106 (2005) Abstract
A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions: T. Atsumi, et al.; Toxicol. In Vitro 19, 1025 (2005) Abstract
Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats: S.A. Guenette, et al.; J. Vet. Pharmacol. Ther. 29, 265 (2006) Abstract
In vitro activity of eugenol against Candida albicans biofilms: M. He, et al.; Mycopathologia 163, 137 (2007) Abstract
Antimicrobial efficacy of eugenol microemulsions in milk against Listeria monocytogenes and Escherichia coli O157:H7: S. Gaysinsky, et al.; J. Food Prot. 70, 2631 (2007) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Analgesic / Anti-nociceptive Agents / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products - Antifungal Agents
 
 
ALX-350-330 Revised 05-Apr-08
Evodiamine
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SYNONYMS 8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-330-M010   10 mg 20.00 USD Add To Cart
ALX-350-330-M050   50 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C19H17N3O
MW: 303.4
CAS NUMBER: 518-17-2
MERCK INDEX: 14: 3908
SOURCE/HOST: Synthetic. Originally isolated from Evodia rutaecarpa.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in DMSO (5mg/ml; warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
A cell permeable, non-pungent vanilloid receptor agonist that induces apoptosis. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells.
Product Specific Literature References
Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci. 75, 612 (1986) Abstract
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod. 60, 708 (1997) Abstract
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull. 24, 917 (2001) Abstract
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci. 94, 92 (2003) Abstract
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin. 25, 83 (2004) Abstract
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis 26, 968 (2005) Abstract
Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther. 5, 2398 (2006) Abstract
Further Categories Containing This Product:
MDR Inhibitors • TRPV1 Agonists and Antagonists / Related Products • Natural Products for Neurological Research • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-300 Revised 05-Apr-08
Fascaplysin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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ALX-270-300-M001   1 mg 60.00 USD Add To Cart
ALX-270-300-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H11N2OCl
MW: 306.8
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Brown powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light.
HAZARD: TOXIC.

Product Description
Originally isolated from a marine sponge. Selective CDK4/cyclin D1 (IC50=350nM) inhibitor (in an ATP competitive manner).
Product Specific Literature References
Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sponge: D.M. Roll, et al.; J. Org. Chem. 53, 3276 (1988)
A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta: G. Kirsch, et al.; J. Nat. Prod. 63, 825 (2000) Abstract
Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product: R. Soni, et al.; BBRC 275, 877 (2000) Abstract
DNA binding properties of the marine sponge pigment fascaplysin: A. Hormann, et al.; Bioorg. Med. Chem. 9, 917 (2001) Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Marine Natural Products • Alkaloids
 
 
ALX-350-137 Revised 05-Apr-08
Fasciculatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-137-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C25H34O4
MW: 398.5
CAS NUMBER: 37905-12-7
SOURCE/HOST: Isolated from Ircinia fasciculata.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL. CYTOTOXIC.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Secondary metabolite of marine sponges. Shows moderate cytotoxicity.
Product Specific Literature References
Fasciculatin, a novel sesterterpene from the sponge Ircinia fasciculate: L. Minale, et al.; Tetrahedron 28, 1579 (1975)
Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin: N.K. Narain, et al.; J. Chem. Soc. [Perkin. 1] 9, I018 (1977) Abstract
Cytotoxicity and inhibition of lymphocyte proliferation of fasciculatin, a linear furanosesterterpene isolated from Ircinia variabilis collected from the atlantic coast of Morocco: S. Rifai, et al.; Mar. Drugs 3, 15 (2005) Full Text
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
 
 
ALX-350-124 Revised 05-Apr-08
Ferulenol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-124-M001   1 mg 45.00 USD Add To Cart
ALX-350-124-M005   5 mg 135.00 USD Add To Cart
ALX-350-124-M010   10 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C24H30O3
MW: 366.5
CAS NUMBER: 6805-34-1
SOURCE/HOST: Isolated from Ferula communis.
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.
Product Specific Literature References
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Natural Products for Cell Cycle Research • Natural Products - Antitumor Reagents
 
 
ALX-350-098 Revised 05-Apr-08
Ferutinin (high purity)
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SYNONYMS Tefestrol (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-098-M001   1 mg 35.00 USD Add To Cart
ALX-350-098-M005   5 mg 100.00 USD Add To Cart
ALX-350-098-M010   10 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C22H30O4
MW: 358.5
SOURCE/HOST: Semisynthetic.
PURITY: ≥98%
SOLUBILITY: Soluble in acetone, dichloromethane, DMSO or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen (Prod. No. ALX-550-095) for both ERs. Electrogenic Ca2+ ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A (Prod. No. ALX-380-002), suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1-50µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca2+.
Product Specific Literature References
Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973)
Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997) Abstract
Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers: A.Y. Abramov, et al.; Biochim. Biophys. Acta 1512, 98 (2001) Abstract
Daucane phytoestrogens: a structure-activity study: G. Appendino, et al.; J. Nat. Prod. 65, 1612 (2002) Abstract
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002) Abstract
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003) Abstract
Further Categories Containing This Product:
Ionophores Other Products • MPTP [Mitochondrial Transition Pore] / Related Products • Estrogen & Estrogen Receptors / Related Products
 
 
ALX-380-008 Revised 05-Apr-08
FK506
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SYNONYMS Tacrolimus
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-008-M001   1 mg 30.00 USD Add To Cart
ALX-380-008-M005   5 mg 60.00 USD Add To Cart
ALX-380-008-M025   25 mg 180.00 USD