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ALX-350-342 Revised 02-Sep-08
Roquefortine C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-350-342-MC05   0.5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C22H23N5O2
MW: 389.5
CAS NUMBER: 58735-64-1
RTECS: UQ4730500
SOURCE/HOST: Isolated from MST-FP1764.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Potent neurotoxin produced by a diverse range of fungi, most notably Penicillium species. Inhibits growth of Gram-positive bacteria. Inhibits cytochrome p450.
Product Specific Literature References
Isolation of festuclavine and three new indole alkaloids, roquefortine A, B and C from the cultures of Penicillium roqueforti: S. Ohmomo, et al.; Agric. Biol. Chem. 39, 1333 (1975)
Antimicrobial action of roquefortine: B. Kopp-Holtwiesche and H.J. Rehm; J. Environ. Pathol. Toxicol. Oncol. 10, 41 (1990) Abstract
Molecular requirements for inhibition of cytochrome p450 activities by roquefortine: C. Aninat, et al.; Chem. Res. Toxicol. 14, 1259 (2001) Abstract
Inhibitory effects of roquefortine on hepatic cytochromes P450: C. Aninat and M. Delaforge; Adv. Exp. Med. Biol. 500, 331 (2001) Abstract
The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes: M. Keblys, et al.; Mycopathologia 158, 317 (2004) Abstract
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Alkaloids • Mycotoxins
 
 
ALX-350-343 Revised 14-Nov-07
Roquefortine E
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-343-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C27H31N5O2
MW: 457.6
CAS NUMBER: 871982-52-4
SOURCE/HOST: Isolated from Gymnoascus reesii MST-FP1700.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Analog of roquefortine C (Prod. No. ALX-350-342). Selective, albeit weakly active antitumor agent.
Product Specific Literature References
Roquefortine E, a diketopiperazine from an Australian isolate of Gymnoascus reessii: B. Clark, et al.; J. Nat. Prod. 68, 1661 (2005) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
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SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985) Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992) Abstract
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998) Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003) Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003) Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004) Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004) Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006) Abstract
Further Categories Containing This Product:
T Cell Regulation Other Products • Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Polyphenols Other Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents
 
 
ALX-350-360 Revised 28-May-08
Rotenone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-360-G001   1 g 45.00 USD Add To Cart
ALX-350-360-G005   5 g 125.00 USD Add To Cart
Product Specification
FORMULA: C23H22O6
MW: 394.4
CAS NUMBER: 83-79-4
MERCK INDEX: 14: 8271
RTECS: DJ2800000
SOURCE/HOST: Synthetic. Originally isolated from Lonchocarpus sp. or Derris sp.
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC50=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding.
Product Specific Literature References
Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967) Abstract
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996) Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005) Abstract; Full Text
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005) Abstract; Full Text
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006) Abstract
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007) Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007) Abstract
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008) Abstract; Full Text
Further Categories Containing This Product:
Apoptosome Other Products • Natural Products for Cytoskeletal Research • Respiratory Chain Other Products • Pesticides / Related Products
 
 
ALX-350-075 Revised 08-Apr-08
Rottlerin
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SYNONYMS Mallotoxin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-075-M010   10 mg 40.00 USD Add To Cart
ALX-350-075-M025   25 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C30H28O8
MW: 516.6
CAS NUMBER: 82-08-6
MERCK INDEX: 14: 8272
RTECS: AM6913800
SOURCE/HOST: Isolated from Mallotus philippinensis.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or 100% ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cδ (PKCδ). However, recent studies indicate that rottlerin has no direct effect on PKCδ and that it should not be used to determine the involvement of PKCδ in biological processes.
Product Specific Literature References
The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion: M. Gschwendt, et al.; Cancer Lett. 25, 177 (1984) Abstract
Rottlerin, a novel protein kinase inhibitor: M. Gschwendt, et al.; BBRC 199, 93 (1994) Abstract
Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine: M. Gschwendt, et al.; FEBS Lett. 338, 85 (1994) Abstract
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta: S.P. Soltoff; TIPS 28, 453 (2007) Abstract
Further Categories Containing This Product:
PKA Inhibitors • CAM Kinase Inhibitors • Casein Kinase Inhibitors • PKC Inhibitors
 
 
ALX-350-324 Revised 30-May-07
Rubellin D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Plant Research Reagents
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ALX-350-324-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C30H22O10
MW: 542.5
SOURCE/HOST: Isolated from fungus Ramularia collo-cygni.
PURITY: ≥98% (HPLC)
APPEARANCE: Red powder.
SOLUBILITY: Soluble in tetrahydrofuran, n-propanol, methanol, ethyl acetate, DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Phytotoxin. Triggers the light-dependent production of reactive oxygen species and α-linolenic acid peroxidation.
Product Specific Literature References
Secondary mould metabolites. XX. The structure of rubellins C and D, two novel anthraquinone metabolites from Mycosphae-rella rubella: A. Arnone et al.; Gazz. Chim. Ital. 119, 35 (1989)
Photodynamic oxygen activation by rubellin D, a phytotoxin produced by Ramularia collo-cygni (Sutton et Waller): I. Heiser et al.; Physiol. Mol. Plant Pathol. 62, 29 (2003)
The phytopathogenic fungus Ramularia collo-cygni produces biologically active rubellins on infected barley leaves: S. Miethbauer et al.; J. Phytopathol. 151, 665 (2003)
Fatty acid peroxidation by rubellin B, C, and D, phytotoxins produced by Ramularia collo-cygni (Sutton et Waller): I. Heiser et al.; Physiol. Mol. Plant Pathol. 64, 135 (2004)
Biosynthesis of photodynamically active rubellins and structure elucidation of new anthraquinone derivatives produced by Ramularia collo-cygni: S. Miethbauer, et al.; Phytochemistry 67, 1206 (2006) Abstract
Further Categories Containing This Product:
Other Toxins • Lipid Peroxidation • Lipid Peroxidation • Plant Research Reagents / Related Products
 
 
ALX-380-120 Revised 08-Apr-08
Rubiginone D2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-120-M001   1 mg 100.00 USD Add To Cart
ALX-380-120-M005   5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C20H16O6
MW: 352.3
SOURCE/HOST: Isolated from Streptomyces sp. (strain Gö N1/5).
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid with a green cast.
SOLUBILITY: Soluble in DMSO or acetone; slightly soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antibacterial and antitumor compound.
Product Specific Literature References
New biologically active rubiginones from Streptomyces sp.: C. Puder, et al.; J. Antibiot. (Tokyo) 53, 329 (2000) Abstract
 
 
ALX-380-067 Revised 08-Apr-08
β-Rubromycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral / Anti-HIV
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ALX-380-067-M001   1 mg 40.00 USD Add To Cart
ALX-380-067-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C27H20O12
MW: 536.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥99%
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of HIV-1 reverse transcriptase (RT). Inhibits human telomerase. Cytostatically active against different tumor cell lines.
Product Specific Literature References
The structure of rubromycin: H. Brockmann, et al.; THL 30, 3525 (1966), (Article in German) Abstract
Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102, 126 (1969) Abstract
Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 1709 (1970) Abstract
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990) Abstract
Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000) Abstract
Structural and Biosynthetic Investigations of the Rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000)
Further Categories Containing This Product:
Telomerase / Related Products • Antibiotics - Immunomodulators • Antitumor Antibiotics • HIV / AIDS / Related Products
 
 
ALX-380-300 Revised 04-Aug-08
Rufloxacin . hydrochloride
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SYNONYMS 6-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid . hydrochloride
MF-934 . hydrochloride
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ALX-380-300-M050   50 mg 50.00 USD Add To Cart
ALX-380-300-M250   250 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3S . HCl
MW: 363.4 . 36.5
CAS NUMBER: 106017-08-7
MERCK INDEX: 14: 8294
PURITY: ≥98% (Assay)
APPEARANCE: Off-white to light green crystalline solid.
SOLUBILITY: Sparingly soluble in water; very slightly soluble in methanol; almost insoluble in chloroform or acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by IR.

Product Description
Fluoroquinolone antibacterial agent. Structurally similar to ofloxacin (Prod. No. ALX-380-297). Specific inhibitor of bacterial DNA gyrase (topoisomerase). Inhibits B-cell differentiation. Shows photosensitizing effects.
Product Specific Literature References
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids: V. Cecchetti, et al.; J. Med. Chem. 30, 465 (1987) Abstract
The in-vitro activity of two new quinolones: rufloxacin and MF 961: R. Wise, et al.; J. Antimicrob. Chemother. 29, 649 (1992) Abstract
Effect of rufloxacin on in-vitro proliferation and differentiation of human mononuclear cells: S. Gollapudi, et al.; J. Antimicrob. Chemother. 29, 669 (1992) Abstract
Multiple-dose pharmacokinetics and safety of rufloxacin in normal volunteers: J.C. Kisicki, et al.; Antimicrob. Agents Chemother. 36, 1296 (1992) Abstract; Full Text
Double-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpatients with exacerbations of chronic bronchitis: W. Klietmann, et al.; Antimicrob. Agents Chemother. 37, 2298 (1993) Abstract; Full Text
Rufloxacin once daily versus ofloxacin twice daily for treatment of complicated cystitis and upper urinary tract infections. Italian Multicentre UTI Rufloxacin Group: R. Mattina, et al.; Infection 21, 106 (1993) Abstract
Comparison of the mechanism of action and resistance of two new fluoroquinolones, rufloxacin and MF961 with those of ofloxacin and fleroxacin in gram-negative and gram-positive bacteria: L.J. Piddock, et al.; J. Antimicrob. Chemother. 31, 855 (1993) Abstract
Molecular mechanisms of photosensitization induced by drugs. XII. Photochemistry and photosensitization of rufloxacin: an unusual photodegradation path for the antibacterials containing a fluoroquinolone-like chromophore: G. Condorelli, et al.; Photochem. Photobiol. 70, 280 (1999) Abstract
Penetration of rufloxacin into the cerebrospinal fluid in patients with inflamed and uninflamed meninges: M.V. Moretti, et al.; Antimicrob. Agents Chemother. 44, 73 (2000) Abstract; Full Text
Rufloxacin-induced photosensitization in yeast: A. Catalfo, et al.; Photochem. Photobiol. Sci. 6, 181 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
ALX-460-028 Revised 24-Oct-07
Rutin . trihydrate