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CD Antibodies
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ALX-805-051 Revised 15-Jul-05
Monoclonal Antibody to CD22 (human) (MEM-01)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-051-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: MEM-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Burkitt's lymphoma cell line Raji.
SPECIFICITY: Recognizes human and monkey CD22. Stains only the zone corresponding to 140kDa. Does not cross-block MAb to CD22 (human) (RFB4) (Prod. No. ANC-171).
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot (non-reducing)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
B Cell Receptor [BCR] & Co-Receptors / Related Products • Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-060 Revised 22-Jun-05
Monoclonal Antibody to CD25 (human) (MEM-181)
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SYNONYMS anti-IL-2Rα (human) MAb (MEM-181)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD25 [IL-2Ralpha] / Related Products
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ALX-805-060-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-181
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: PHA-activated peripheral blood leukocytes.
SPECIFICITY: Recognizes human CD25.
APPLICATION: Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-003 Revised 23-Nov-05
Monoclonal Antibody to CD31 (human) (Gi18)
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SYNONYMS anti-PECAM-1 (human) MAb (Gi18)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-003A-C100 Purified 100 µg 250.00 USD Add To Cart
ALX-805-003B-T100 Biotin 100 tests 308.00 USD Add To Cart
ALX-805-003F-T100 FITC 100 tests 308.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Gi18
ISOTYPE: Mouse IgG1
PURITY: >95% (SDS-PAGE)
FORMULATION: Gi18-Purified: Liquid. 1mg/ml in PBS. Contains no preservatives.
Gi18-FITC and Biotin: Liquid. 100 tests in 1ml of 50mM TRIS, pH 7.4, containing 100mM NaCl, 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Human platelets.
SPECIFICITY: Recognizes the Ig loops 1-2 of human CD31 (PECAM-1).
APPLICATION: Gi18-Purified:
Flow Cytometry (suitable as a primary antibody (2µg/ml))
Immunohisotchemistry (frozen sections, paraffin sections)
Western Blot
Gi18-Biotin:
Flow Cytometry (two-step procedure using the biotin-(strept-)avidin system)
Gi18-FITC:
Flow Cytometry (direct staining (1:20))
Optimal conditions must be determined individually for each
application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. Keep Biotin- and FITC-conjugated formats at +4°C. Protect from light.
Product Specific Literature References
S.F. Schlossman, et al,; Oxford University Press - Leucocyte Typing V 1261 (1995)
Further Categories Containing This Product:
Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products • Monoclonal Antibodies
 
 
ALX-805-029 Revised 12-Jan-05
Monoclonal Antibody to CD31 (human) (Gi34)
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SYNONYMS anti-PECAM-1 (human) Mab (Gi34)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-029-C100   100 µg 230.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Gi34
ISOTYPE: Mouse IgG1
PURITY: >95%.
FORMULATION: Liquid. 100µg of purified antibody in 200µl PBS containing 0.05% sodium azide.
IMMUNOGEN: Human platelets.
SPECIFICITY: Recognizes the Ig loops 2-3 of human CD31.
APPLICATION: Antigen Capture Assay
Immunoprecipitation
Western Blot (1:20)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
S.F. Schlossman, et al.,; Oxford University Press - Leucocyte Typing V 1261 (1995)
Further Categories Containing This Product:
Monoclonal Antibodies • Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products
 
 
ALX-805-039 Revised 19-May-05
Monoclonal Antibody to CD36 (63)
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PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-039-C100   100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE: 63
ISOTYPE: Mouse IgA
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein L purified antibody in PBS containing 20% glycerol.
IMMUNOGEN: Recombinant mouse CD36.
SPECIFICITY: Recognizes mouse and rat CD36.
APPLICATION: Flow Cytometry (1:1’000)
Immunocytochemistry (1:1’000)
Immunoprecipitation (1:1’000)
Functional Application (blocks uptake of oxidized LDL by mouse macrophages and prevents foam cell formation in vitro).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Obesity & Diabetes Other Products • Monoclonal Antibodies
 
 
ALX-802-029 Revised 27-Dec-06
Monoclonal Antibody to CD39L1 (mouse) (NOGU3-B28)
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SYNONYMS anti-Ectonucleoside Triphosphate Diphosphohydrolase 2 (mouse) MAb (NOGU3-B28)
anti-NTPDase 2 (mouse) MAb (NOGU3-B28)
anti-ENTPD2 (mouse) MAb (NOGU3-B28)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-802-029-L001   1 ml 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: NOGU3-B28
ISOTYPE: Rat IgG2b
FORMULATION: Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of mouse CD39L1.
SPECIFICITY: Recognizes mouse CD39L1.
APPLICATION: Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Literature References
Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system: N. Braun, et al.; Glia 45, 124 (2004) Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation: S.C. Robson, et al.; Semin. Thromb. Hemost. 31, 217 (2005), (Review) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-805-046 Revised 21-Feb-07
Monoclonal Antibody to CD40 (mouse) (FGK45)
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SYNONYMS anti-TNFRSF 5 (mouse) MAb (FGK45)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
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ALX-805-046B-C050 Biotin 50 µg 150.00 USD Add To Cart
ALX-805-046-C100   100 µg 165.00 USD Add To Cart
ALX-805-046-C500   500 µg 440.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: FGK45
ISOTYPE: Rat IgG2a
CONCENTRATION: FGK45: 1mg/ml
FGK45-Biotin: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In sterile PBS.
IMMUNOGEN: Recombinant mouse CD40 fusion protein.
SPECIFICITY: Recognizes mouse CD40.
APPLICATION: Flow Cytometry
Functional Application (activates B and NK cells in vivo and in vitro)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY:

For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep Biotin-conjugated formats at +4°C. Do not freeze. Protect from light.
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Product Description
Widely used stimulatory MAb to CD40 [1,2]. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects [3]. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes [4]. 
Product Specific Literature References
[1] The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996) Abstract
[2] Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998) Abstract
[3] Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001) Abstract
[4] Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000) Abstract
Click here for a complete literature overview:
[40] Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004) Abstract; Full Text
[41] CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004) Abstract; Full Text
[42] IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005) Abstract
[43] In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006) Abstract
[44] IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006) Abstract
[45] Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-037 Revised 13-Feb-07
Monoclonal Antibody to CD40L (human) (blocking) (MK13A4)
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SYNONYMS anti-CD154 (human) MAb (blocking) (MK13A4)
anti-gp39 (human) MAb (blocking) (MK13A4)
anti-TNFSF 5 (human) MAb (blocking) (MK13A4)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
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ALX-805-037-C100 Purified 100 µg 259.00 USD Add To Cart
ALX-805-037B-T100 Biotin 100 tests 308.00 USD Add To Cart
ALX-805-037F-T100 FITC 100 tests 308.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MK13A4
ISOTYPE: Mouse IgG1
QUANTITY: MK13A4: 100µl
MK13A4-Biotin: 1ml
MK13A4-FITC: 1ml
FORMULATION: MK13A4: Liquid. 1mg/ml in PBS.
MK13A4-Biotin and -FITC: Liquid. In 50mM TRIS, pH 7.4, containing 100mM sodium chloride, 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Recombinant human CD40L (CD154).
SPECIFICITY: Recognizes human CD40L.
APPLICATION: Flow Cytometry
Functional Application (blocks binding of CD40L to its receptor CD40)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-331 Revised 14-Mar-06
Monoclonal Antibody to CD40L (mouse) (MR1)
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SYNONYMS anti-CD154 (mouse) MAb (MR1)
anti-gp39 (mouse) MAb (MR1)
anti-TNFSF 5 (mouse) MAb (MR1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD40 & CD40L [CD154] / Related Products
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ALX-804-331-C100   100 µg 259.00 USD Add To Cart
ALX-804-331-C500   500 µg 490.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: MR1
ISOTYPE: Hamster IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Recombinant mouse CD40L (CD154).
SPECIFICITY: Recognizes mouse CD40L.
APPLICATION: Functional Application (blocks T cell co-stimulation in vivo, promoting allograft acceptance and donor-specific tolerance to secondary skin grafts).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway: C.P. Larsen, et al.; Transplantation 61, 4 (1996) Abstract
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Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-024 Revised 27-Jun-06
Monoclonal Antibody to CD41a (human) (Gi5)
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SYNONYMS anti-CD41/CD61 Complex (human) MAb (Gi5)
anti-GPIIb/GPIIIa Complex (human) MAb (Gi5)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-024-C100   100 µg 230.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Gi5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY: >95%.
FORMULATION: Liquid. Purified antibody in PBS containing 0.05% sodium azide.
IMMUNOGEN: Human platelets.
SPECIFICITY: Recognizes human CD41a (CD41/CD61 Complex).
APPLICATION: Antigen Capture Assay
Flow Cytometry
Immunocytochemistry
Immunoprecipitation
Functional Application (inhibits fibrinogen binding)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
A point mutation leads to an unparied cysteine residue and a molecular weight polymorphism of a functional platelet beta-3 integrin subunit: S. Santoso, et al.; J. Biol. Chem. 269, 8439 (1994) Abstract; Full Text
Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura: V. Kiefel, et al.; Br. J. Haematol. 79, 256 (1991) Abstract
Further Categories Containing This Product:
Integrins / Related Products • Monoclonal Antibodies
 
 
ALX-805-025 Revised 27-Jun-06
Monoclonal Antibody to CD41b (human) (Gi16)
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SYNONYMS anti-CD41 (human) MAb (Gi16)
anti-GPIIb (human) MAb (Gi16)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-025-C100   100 µg 230.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Gi16
ISOTYPE: Mouse IgG1
CONCENTRATION: