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Cancer
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ALX-480-029 Revised 26-Sep-08
8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
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SYNONYMS 8-Cl-cAMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
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ALX-480-029-M001   1 mg 27.00 USD Add To Cart
ALX-480-029-M005   5 mg 108.00 USD Add To Cart
Product Specification
FORMULA: C10H11ClN5O6P . Na
MW: 363.7 . 23.0
CAS NUMBER: 41941-56-4
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water and aqueous buffers. May produce hazy solutions.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Specific Literature References
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth: S. Ally, et al.; PNAS 85, 6319 (1988) Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-550-257 Revised 10-Feb-05
Amiloride, 5-(N-Methyl-N-isobutyl)-
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SYNONYMS 5-(N-Methyl-N-isobutyl)amiloride
MIA
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ Channels
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ALX-550-257-M005   5 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C11H18ClN7O
MW: 299.8
CAS NUMBER: 96861-65-3
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in dilute aqueous acid or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent inhibitor of the Na+/H+ antiporter. Possible antitumor agent.
Product Specific Literature References
Interactions of chloride and amiloride with the renal Na+/H/ antiporter: D.G. Warnock, et al.; J. Biol. Chem. 263, 7216 (1988) Abstract; Full Text
Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters: Z. Talor, et al.; Life Sci. 45, 517 (1989) Abstract
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy: R.P. Maidorn, et al.; Br. J. Cancer. 67, 297 (1993) Abstract
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC: I.Y. Novikova, et al.; Biochim. Biophys. Acta 1178, 267 (1993) Abstract
Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats: K.L. Lauro, et al.; Brain Res. 831, 64 (1999) Abstract
Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart: X.H. Xiao & D.G. Allen; Circ. Res. 85, 723 (1999) Abstract
Further Categories Containing This Product:
Imidazoline Binding Site Ligands • Ca2+ Channels (T-type) • Antitumor Reagents Other Products
 
 
ALX-550-409 Revised 18-May-06
Tranilast
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SYNONYMS N-(3’,4’-Dimethoxycinnamoyl)anthranilic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Anti-inflammatory Agents Other Products
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ALX-550-409-M010   10 mg 70.00 USD Add To Cart
ALX-550-409-M050   50 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C18H17NO5
MW: 327.3
CAS NUMBER: 53902-12-8
MERCK INDEX: 14: 9570
RTECS: DG8731000
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description

Anti-inflammatory and anti-angiogenic agent. Exerts its effects by inhibiting the expression of mediators such as MCP-1,  TGF-β, TNF-α induced vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin.
Product Specific Literature References
Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages: H. Suzawa, et al.; Jpn. J. Pharmacol. 60, 85 (1992) Abstract
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts: H. Yamada, et al.; J. Biochem. 116, 892 (1994) Abstract
Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells: A. Chikaraishi, et al.; Eur. J. Pharmacol. 427, 151 (2001) Abstract
Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells: M. Spiecker, et al.; Mol. Pharmacol. 62, 856 (2002) Abstract; Full Text
Tranilast: a novel weapon against insulin resistance: M.R. Namazi & J. Soma; Med. Hypotheses 64, 1135 (2005) Abstract
Further Categories Containing This Product:
Angiogenesis Modulators Other Products • Antitumor Reagents Other Products
 
 
ALX-430-063 Revised 10-Oct-07
Anthralin
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SYNONYMS Dithranol
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-430-063-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C14H10O3
MW: 226.2
CAS NUMBER: 1143-38-0
MERCK INDEX: 14: 684
RTECS: CB8927000
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. IRRITANT.

Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB4 ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils: J.M. Schröder; J. Invest. Dermatol. 87, 624 (1986) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Cancer Other Products
 
 
ALX-430-074 Revised 18-Jan-05
TJU103
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SYNONYMS N-(3-Indolylmethylene)-isonicotinic hydrazone
PRODUCT LINE Immunology
PRODUCT CATEGORY Immunomodulators Other Products
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ALX-430-074-M010   10 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C15H12N4O
MW: 264.3
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas.

Product Description
A non-peptidic, non-toxic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune response in animal models of autoimmune disease.
Product Specific Literature References
A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics: S. Li, et al.; PNAS 94, 73 (1997) Abstract; Full Text
Further Categories Containing This Product:
CD4 / Related Products • Cancer Other Products
 
 
ALX-270-270 Revised 17-Mar-08
Pifithrin-α . hydrobromide
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SYNONYMS 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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ALX-270-270-M005   5 mg 50.00 USD Add To Cart
ALX-270-270-M010   10 mg 85.00 USD Add To Cart
ALX-270-270-M025   25 mg 200.00 USD Add To Cart
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Product Specification
FORMULA: C16H18N2OS . HBr
MW: 286.4 . 80.9
CAS NUMBER: 63208-82-2
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.
IDENTITY: Determined by 1H-NMR.

Product Description
Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis.
Product Specific Literature References
Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999) Abstract
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999) Abstract
Suppression of p53: a new approach to overcome side effects of antitumor therapy: E.A. Komarova & A.V. Gudkov; Biochemistry (Mosc) 65, 41 (2000), (Review) Abstract; Full Text
Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes: A. Lakkaraju, et al.; J. Biol. Chem. 276, 32000 (2001) Abstract; Full Text
Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons: C. Alves da Costa, et al.; PNAS 99, 4043 (2002) Abstract
Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio: D. Javelaud & F. Besancon; J. Biol. Chem. 277, 37949 (2002) Abstract; Full Text
Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes: F.U. Muller, et al.; Cell Death Differ. 11, 485 (2004) Abstract
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J. Biol. Chem. 279, 30195 (2004) Abstract
 
 
ALX-270-287 Revised 26-Jun-08
Pifithrin-α (cyclic) . hydrobromide
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SYNONYMS 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole . HBr
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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ALX-270-287-M010   10 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C16H16N2S . HBr
MW: 268.4 . 80.9
CAS NUMBER: 60477-34-1
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (100mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Keep under inert gas.

Product Description
Stable analog of pifithrin-α (Prod. No. ALX-270-270), with biological properties similar to its parent compound, but with reduced cytotoxicity. Inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Potent STAT6 transcriptional inhibitor.
Product Specific Literature References
Cancer research. A new way to combat therapy side effects: D. Ferber; Science 285, 1651 (1999) Abstract
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy: P.G. Komarov, et al.; Science 285, 1733 (1999) Abstract
Suppression of p53: a new approach to overcome side effects of antitumor therapy: E.A. Komarova, et al.; Biochemistry 65, 41 (2000) Abstract; Full Text
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation: P.J. Murphy, et al.; J Biol Chem 279, 30195 (2004) Abstract
Related Products
 
 
ALX-270-310 Revised 10-Jul-08
PRIMA-1
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SYNONYMS 2,2-bis(Hydroxymethyl)-3-quinuclidinone
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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ALX-270-310-M001   1 mg 23.00 USD Add To Cart
ALX-270-310-M005   5 mg 101.00 USD Add To Cart
Product Specification
FORMULA: C9H15NO3
MW: 185.2
CAS NUMBER: 5608-24-2
PURITY: ≥95%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 2.5mg/ml soluble in PBS, pH 7.2 .
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Restores sequence-specific DNA binding and the active conformation to mutant p53 proteins in vitro and in vivo, thus triggering apoptosis of cancer cells.
Product Specific Literature References
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound: V.J. Bykov, et al.; Nat. Med. 8, 282 (2002) Abstract
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers)
 
 
ALX-270-437 Revised 07-Oct-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
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ALX-270-437-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H13ClN2O
MW: 248.7
CAS NUMBER: 49843-98-3
PURITY: ≥95%
APPEARANCE: White to beige powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38nM in vitro; compared to hSIRT2: IC50=19µM and hSIRT3: IC50=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC50>100µg). Inhibits the deacetylation of p53 (IC50=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1: A.D. Napper, et al.; J. Med. Chem. 48, 8045 (2005) Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes: J.C. Milne, et al.; Nature 450, 712 (2007) Abstract
Further Categories Containing This Product:
p53 Other Products
 
 
ALX-350-015 Revised 02-Dec-08
(S)-(+)-Camptothecin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Topoisomerase Inhibitors
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ALX-350-015-M050   50 mg 40.00 USD Add To Cart
ALX-350-015-M250   250 mg 150.00 USD Add To Cart
ALX-350-015-G001   1 g 295.00 USD Add To Cart
Product Specification
FORMULA: C20H16N2O4
MW: