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Cytoskeleton
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ALX-201-246 Revised 24-Apr-08
Matriptase (human) (recombinant)
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SYNONYMS MT-SP1 (human) (recombinant)
Membrane-type Serine Protease 1 (human) (recombinant)
ST14 (human) (recombinant)
Suppression of Tumorigenicity Protein 14 (human) (recombinant)
TADG-15 (human) (recombinant)
Tumor-associated Differentially Expressed Gene 15 Protein (human) (recombinant)
SNC19 (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-246-U125   125 U 360.00 USD Add To Cart
Product Specification
MW: ~25kDa
SOURCE/HOST: Recombinant human matriptase (aa 596-855) fused at the N-terminus to a His-tag.
CONCENTRATION: 100nM
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 100mM TRIS, pH 9.0, containing 200mM sodium chloride, 1mM β-mercaptoethanol and 10% glycerol.
ACTIVITY: Trypsin-like serine protease.
SPECIFIC ACTIVITY: ~2.5U/µl. One unit is defined as the amount of enzyme that releases 1nmol of AMC per min. at 37°C in the presence of 50µM of Boc-Gln-Ala-Arg-AMC.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C. Do not store diluted solutions.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue: T. Takeuchi, et al.; PNAS 96, 11054 (1999) Abstract; Full Text
Inhibition of human matriptase by eglin c variants: A. Désilets, et al.; FEBS Lett. 580, 2227 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Recommended Assay Buffer:
100mM TRIS, pH 9.5, containing 5mg/ml BSA.
Further Categories Containing This Product:
Cancer Other Products • Cytoskeleton & Extracellular Matrix Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-260-121 Revised 08-Jul-05
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-121-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: 1680.0
PURITY: ≥97%
APPEARANCE: Yellow solid.
SOLUBILITY: DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry. Protect from light.
Product Description
Fluorogenic substrate for MMP-3 and MMP-9.
 
 
ALX-260-122 Revised 12-Jun-03
Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Substrates
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ALX-260-122-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C51H65N13O15
MW: 1100.2
PURITY: ≥97%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Fluorogenic substrate for MMP-13.
Product Specific Literature References
Biochemical characterization of human collagenase-3: V. Knäuper, et al.; J. Biol. Chem. 271, 1544 (1996) Abstract; Full Text
 
 
ALX-260-123 Revised 14-Dec-04
Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Substrates
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ALX-260-123-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: 1093.0
PURITY: ≥97%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry. Protect from light.
Product Description
Fluorogenic substrate for MMP-2.
 
 
ALX-260-125 Revised 12-Jun-03
Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Substrates
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ALX-260-125-M001   1 mg 190.00 USD Add To Cart
ALX-260-125-M005   5 mg 684.00 USD Add To Cart
Product Specification
FORMULA: C49H68N14O15
MW: 1093.2
PURITY: ≥97%
APPEARANCE: Yellow solid.
SOLUBILITY: DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry. Protect from light.
Product Description
Fluorogenic substrate for MMP-2 and MMP-7.
 
 
ALX-201-381 Revised 18-Mar-08
MFAP4 (human) (recombinant)
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SYNONYMS Microfibril-associated Glycoprotein 4 (human) (recombinant)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Adhesion Molecules & Receptors Other Products
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ALX-201-381-C010   10 µg 180.00 USD Add To Cart
ALX-201-381-C050   50 µg 480.00 USD Add To Cart
Product Specification
MW: ~36kDa
SOURCE/HOST: Produced in HEK 293 cells. Human MFAP4 [microfibril-associated glycoprotein 4] (aa 1-255) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
ANGPTL2, ANGPTL3, ANGPTL5 and ANGPTL7 have recently been shown to stimulate the ex vivo expansion of the hematopoietic stem cells. The same report showed that the microfibril-associated glycoprotein 4 (MFAP4), which exhibits sequence similarity to ANGPTLa, also posesses such ex vivo expansion activity [1].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P55083: MFAP4 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-173 Revised 18-May-06
Midkine (human) (recombinant) (His)
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SYNONYMS ARAP (human) (recombinant) (His)
Amphiregulin-associated Protein (human) (recombinant) (His)
Neurite Outgrowth-promoting Factor 2 (human) (recombinant) (His)
RIHB (human) (recombinant) (His)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
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ALX-201-173-C100   100 µg 532.00 USD Add To Cart
Product Specification
MW: 14.6kDa (for the fusion protein)
SOURCE/HOST: Produced in E. coli. Human midkine is fused at the N-terminus to a His-tag.
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Sterile filtered.
FORMULATION: Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride..
RECONSTITUTION: Reconstitute with 200µl of PBS, pH 7.2.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 2 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Midkine is a retinoic acid inducible heparin binding protein. Promotes neuronal survival and neurite outgrowth and plays a role in carcinogenesis and tissue remodeling. Midkine expression is induced during remodeling after bone fractures.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-083 Revised 05-Oct-06
Milrinone
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SYNONYMS 1,6-Dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-270-083-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C12H9N3O
MW: 211.2
CAS NUMBER: 78415-72-2
MERCK INDEX: 14: 6197
PURITY: ≥97%
APPEARANCE: Light red solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of phosphodiesterase 3 (PDE3).
Product Specific Literature References
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol. 29, 506 (1986) Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989) Abstract
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels: S.H. Lindgren, et al.; Acta Physiol. Scand. 140, 209 (1990) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor: D. Wilhelm, et al.; J. Cardiovasc. Pharmacol. 20, 705 (1992) Abstract
Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery: J.M. Bailey, et al.; Anesthesiology 81, 616 (1994) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
 
 
ALX-270-088 Revised 07-Apr-05
ML-7 . hydrochloride
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SYNONYMS 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-270-088-M005   5 mg 40.00 USD Add To Cart
ALX-270-088-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C15H17IN2O2S . HCl
MW: 416.0 . 36.5
CAS NUMBER: 110448-33-4
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (can be further diluted with water), 100% ethanol (warm) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibits smooth-muscle myosin light chain kinase, protein kinase C (PKC), and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987) Abstract; Full Text
Further Categories Containing This Product:
PKC Inhibitors • PKA Inhibitors • Myosin Light Chain Kinase Inhibitors
 
 
ALX-270-084 Revised 28-Jan-05
ML-9 . hydrochloride
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SYNONYMS 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-270-084-M010   10 mg 65.00 USD Add To Cart
ALX-270-084-M025   25 mg 125.00 USD Add To Cart
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Product Specification
FORMULA: C15H17ClN2O2S . HCl
MW: 324.8 . 36.5
CAS NUMBER: 105637-50-1
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of myosin light chain kinase, protein kinase C (PKC) and protein cAMP-dependent protein kinase (PKA). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Product Specific Literature References
The modulatory role of myosin light chain phosphorylation in human platelet activation [published erratum appears in Biochem Biophys Res Commun 1987 Jan 15;142(1):287]: M. Saitoh, et al.; BBRC 140, 280 (1986) Abstract
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; BBRC 143, 1045 (1987) Abstract
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987) Abstract; Full Text
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol. 195, 267 (1991) Abstract
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res. 18, 317 (1993) Abstract
Further Categories Containing This Product:
PKC Inhibitors • PKA Inhibitors • Myosin Light Chain Kinase Inhibitors
 
 
ALX-260-165 Revised 10-Nov-08
MMP-3 Inhibitor
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SYNONYMS Ac-RCGVPD-NH2
Stromelysin-1 Inhibitor
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Inhibitors
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ALX-260-165-M001   1 mg 45.00 USD Add To Cart
ALX-260-165-M005   5 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Arg-Cys-Gly-Val-Pro-Asp-NH2
FORMULA: C27H46N10O9S
MW: 686.8
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of matrix metalloproteinase 3 (MMP-3) (IC50=5µM).
Product Specific Literature References
Peptides based on the conserved predomain sequence of matrix metalloproteinases inhibit human stromelysin and collagenase: A.C. Hanglow, et al.; Agents Actions 39, C148 (1993) Abstract
Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases: N. Fotouhi, et al.; J. Biol. Chem. 269, 30227 (1994) Abstract