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Adhesion Molecules & Receptors / Related Products
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ALX-850-059 Revised 17-Apr-08
VE-cadherin, Soluble ELISA Kit
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Kits & Sets
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ALX-850-059-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.15ng/ml (range 0.16 to 10ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of soluble human VE-cadherin in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store standard and biotin-conjugate at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-238 Revised 17-Apr-08
CD162, Soluble (human) ELISA Kit
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SYNONYMS PSGL-1, Soluble (human) ELISA Kit
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Kits & Sets
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ALX-850-238-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.99U/ml (range 1.6 to 50U/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of soluble human CD162 (sPSGL-1) in cell culture supernatants, serum and other body fluids. No cross-reaction with circulating factors of the immune system.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Selectins / Related Products • ELISA & EIA Kits
 
 
ALX-522-109 Revised 14-Apr-08
DCC (Fibronectin Domain 5) (human) (recombinant)
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SYNONYMS Deleted in Colorectal Cancer Protein (Fibronectin Domain 5) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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ALX-522-109-C050   50 µg 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The fibronectin domain 5 (FBN5) of human DCC (aa 841-941) is fused to a N-terminal tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human netrin-1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer: J. Fitamant, et al.; PNAS 105, 4850 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q16218: Deleted in Colorectal Cancer Protein (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin: B.V. Geisbrecht, et al.; J. Biol. Chem. 278, 32561 (2003) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Fibronectin / Related Products
 
 
ALX-201-184 Revised 01-Mar-05
LAIR-1 (22-125) (human) (recombinant)
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SYNONYMS Leukocyte-associated Ig-like Receptor 1 (22-125) (human) (recombinant)
CD305 (22-125) (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY Killer Cell Immunoglobulin-like Receptors [KIRs] / Related Products
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ALX-201-184-C100   100 µg 325.00 USD Add To Cart
Product Specification
MW: ~11.7kDa.
SOURCE/HOST: Produced in E. coli. Extracellular domain of human LAIR-1 (aa 22-125).
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride and 1mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. It features of a leader sequence, extracellular domain, transmembrane domain and a cytoplasmic region.
General Literature References
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes: L. Meyaard, et al.; Immunity 7, 283 (1997) Abstract
LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells: L. Meyaard; Curr. Top. Microbiol. Immunol. 244, 151 (1999) Abstract
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells: L. Meyaard, et al.; J. Immunol. 162, 5800 (1999) Abstract; Full Text
Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells: J.G. Sathish, et al.; J. Immunol. 166, 1763 (2001) Abstract; Full Text
Further Categories Containing This Product:
Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-381 Revised 18-Mar-08
MFAP4 (human) (recombinant)
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SYNONYMS Microfibril-associated Glycoprotein 4 (human) (recombinant)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Adhesion Molecules & Receptors Other Products
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ALX-201-381-C010   10 µg 180.00 USD Add To Cart
ALX-201-381-C050   50 µg 480.00 USD Add To Cart
Product Specification
MW: ~36kDa
SOURCE/HOST: Produced in HEK 293 cells. Human MFAP4 [microfibril-associated glycoprotein 4] (aa 1-255) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
ANGPTL2, ANGPTL3, ANGPTL5 and ANGPTL7 have recently been shown to stimulate the ex vivo expansion of the hematopoietic stem cells. The same report showed that the microfibril-associated glycoprotein 4 (MFAP4), which exhibits sequence similarity to ANGPTLa, also posesses such ex vivo expansion activity [1].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P55083: MFAP4 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-804-393 Revised 31-Oct-06
Monoclonal Antibody to M-cadherin (mouse) (12G4)
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PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Antibodies
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ALX-804-393-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 12G4
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.1% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15min, RT).
IMMUNOGEN: Recombinant mouse M-cadherin extracellular domain.
SPECIFICITY: Recognizes mouse M-cadherin.
APPLICATION: Immunocytochemistry (5µg/ml)
Western Blot (1µg/ml for AP/BCIP/NBT (MTT) detection; 0.5µg/ml for HRPO/ECL detection)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
General Information
Cadherins are a family of transmembrane glycoproteins that play a key role in calcium dependent cell-cell adhesion. Several members of the cadherin family have been identified so far, including E- (epithelial), P- (placental), N- (neuronal) and M- (muscle) cadherin. M-Cadherin is expressed in myoblasts and might be involved in skeletal muscle cell differentiation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-202 Revised 23-Sep-08
Monoclonal Antibody to E-cadherin (ECCD-2)
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SYNONYMS anti-Uvomorulin MAb (ECCD-2)
anti-CD324 MAb (ECCD-2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Antibodies
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ALX-804-202-C100   100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
CLONE: ECCD-2
ISOTYPE: Rat IgG2a
SOURCE/HOST: Obtained by fusing the P3-X63-Ag8 myeloma cell line with splenocytes of Donryu rat immunized with mouse liver E-cadherin fragment.
CONCENTRATION: 2mg/ml after reconstitution.
PURITY DETAIL: Purified from serum-free culture supernatant by ammonium sulfate precipitation and anion exchange chromatography.
FORMULATION: Lyophilized from 20mM TBS, pH 7.5, containing 1% BSA. Contains no preservatives.
RECONSTITUTION: Reconstitute with 50µl distilled water. Dilute with 20mM TBS, pH 7.4, 10mM CaCl2, 1.0% BSA. Reconstituted solution should contain 0.1% sodium azide as a preservative when stored at +4°C.
IMMUNOGEN: Mouse liver E-cadherin fragment.
SPECIFICITY: Recognizes human, mouse and dog E-cadherin. Does not cross-react with bovine or chicken E-cadherin.
APPLICATION: Immunohistochemistry (frozen sections (10µg/ml), not recommended for paraffin sections)
Western Blot (10µg/ml)
Functional Application Does not inhibit E-cadherin dependent cell-cell contact and can be used to analyze the mechanism.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin: Y. Shirayoshi, et al.; Cell Struct. Funct. 11, 245 (1986) Abstract
Transformation of cell adhesion properties by exogenously introduced E- cadherin cDNA: A. Nagafuchi, et al.; Nature 329, 341 (1987) Abstract
The cadherins: cell-cell adhesion molecules controlling animal morphogenesis: M. Takeichi; Development 102, 639 (1988) Abstract
Cadherin cell adhesion receptors as a morphogenetic regulator: M. Takeichi; Science 251, 1451 (1991) Abstract
Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7): P.I. Karecla, et al.; Eur. J. Immunol. 25, 852 (1995) Abstract
Role of IQGAP1, a target of the small GTPase Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion: S. Kuroda, et al.; Science 281, 832 (1998) Abstract
The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells: S. Wallis, et al.; Mol. Biol. Cell. 11, 1077 (2000) Abstract
Recruitment and activation of Rac1 by the formation of E-cadherin- mediated cell-cell adhesion sites: M. Nakagawa, et al.; J. Cell. Sci. 114, 1829 (2001) Abstract
Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit: O. Vagin, et al.; J. Biol. Chem. 283, 2192 (2008) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Buffers should contain Ca2+ to stabilize cadherin antigen. In case of immunohistochemical staining of acetone fixed frozen sections, Ca2+ is not necessary.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-201 Revised 23-Jun-08
Monoclonal Antibody to E-cadherin (HECD-1)
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SYNONYMS anti-Uvomorulin MAb (HECD-1)
anti-CD324 MAb (HECD-1)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Antibodies
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ALX-804-201-C100   100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
CLONE: HECD-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Obtained by fusing the P3-X63-Ag8-U1 myeloma cell line with splenocytes of BALB/c mouse immunized with human breast tumor cell line MCF-7.
CONCENTRATION: 2mg/ml after reconstitution.
PURITY DETAIL: Ammonium sulfate precipitation and ion exchange chromatography.
FORMULATION: Lyophilized from 10mM PBS, pH 7.4 , containing 1% BSA. Contains no preservatives.
RECONSTITUTION: Reconstitute with 50µl distilled water. Dilute with 20mM TBS, pH 7.4, 10mM CaCl2, 1.0% BSA. Reconstituted solution should contain 0.1% sodium azide as a preservative when stored at +4°C.
IMMUNOGEN: Human breast tumor cell line MCF-7.
SPECIFICITY: Recognizes human and guinea pig E-cadherin. Does not cross-react with rat, dog, bovine or chicken E-cadherin.
APPLICATION: ELISA (2-10µg/ml)
Flow Cytometry (1µg/ml)
Immunohistochemistry (frozen sections (2-10µg/ml), paraffin sections (2-10µg/ml))
Western Blot (2-10µg/ml)
Functional Application (100µg/ml for inhibition of E-cadherin dependent cell-cell contact)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas: Y. Shimoyama, et al.; Cancer Res. 49, 2128 (1989) Abstract
Expression of immunoreactive E-cadherin adhesion molecules in human cancers: H. Shiozaki, et al.; Am. J. Pathol. 139, 17 (1991) Abstract
Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections: S.R. Shi, et al.; J. Histochem. Cytochem. 39, 741 (1991) Abstract
Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma: Y. Shimoyama & S. Hirohashi; Cancer Lett. 57, 131 (1991) Abstract
Expression of E- and P-cadherin in gastric carcinomas: Y. Shimoyama & S. Hirohashi; Cancer Res. 51, 2185 (1991) Abstract
Cadherin cell adhesion receptors as a morphogenetic regulator: M. Takeichi; Science 251, 1451 (1991) Abstract
Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas: Y. Tohma, et al.; Cancer Res. 52, 1981 (1992) Abstract
J.A. Jankowski, et al.; Int. J. Oncol. 4, 441 (1994)
CD123bright plasmacytoid predendritic cells: progenitors undergoing cell fate conversion?: M.R. Comeau, et al.; J. Immunol. 169, 75 (2002) Abstract; Full Text
Changing etiology of tubal pregnancy following IVF: A. Revel, et al.; Hum. Reprod. 6, 1372 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Ca2+ should be contained in all buffers to stabilize cadherin antigen.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-203 Revised 06-Mar-08
Monoclonal Antibody to E-cadherin (human) (SHE78-7)
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SYNONYMS anti-Uvomorulin (human) MAb (SHE78-7)
anti-CD324 (human) MAb (SHE78-7)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Cadherin Antibodies
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ALX-804-203-C100   100 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: SHE78-7
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Obtained by fusing the P3-X63-Ag8-U1 myeloma cell line with splenocytes of BALB/c mouse immunized with soluble E-cadherin from human placenta.
CONCENTRATION: 2mg/ml after reconstitution.
PURITY DETAIL: Purified from ascites by ammonium sulfate precipitation and anion exchange chromatography.
FORMULATION: Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA. Contains no preservatives.
RECONSTITUTION: Reconstitute with 50µl distilled water. Dilute with 20mM TBS, pH 7.4, 10mM CaCl2, 1% BSA. Reconstituted solution should contain 0.1% sodium azide as a preservative when stored at +4°C.
Note: TBS should be used for dilution, as PBS causes precipitation.
IMMUNOGEN: Soluble E-cadherin from human placenta.
SPECIFICITY: Recognizes human E-cadherin. Does not cross-react with rat E-cadherin.
APPLICATION: ELISA (2µg/ml)
Flow Cytometry (1µg/ml)
Immunohistochemistry (frozen sections (2µg/ml), paraffin sections (2µg/ml); good results were obtained by incubating with the primary antibody at 4°C overnight);
Western Blot (2µg/ml; reducing and non-reducing conditions);
Functional Application (1µg/ml for inhibition of E-cadherin-dependent cell-cell contact)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Soluble E-cadherin fragments increased in circulation of cancer patients: M. Katayama, et al.; Br. J. Cancer 69, 580 (1994) Abstract
Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line: M. Watabe, et al.; J. Cell. Biol. 127, 247 (1994) Abstract; Full Text
Soluble fragment of E-cadherin cell adhesion molecule increase in urinary excretion of cancer patients, potentially indicating its shedding from epithelial tumour cells: M. Katayama, et al.; Int. J. Oncol. 5, 1049 (1994)
General Information
BACKGROUND/TECHNICAL INFORMATION Ca2+ should be contained in the buffers to stabilize cadherin antigen. In case of immunohistochemical staining of paraffin embedded tissues and acetone fixed frozen sections, Ca2+ is not necessary.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-805-061 Revised 15-Apr-08
Monoclonal Antibody to CD11a (human) (MEM-25)
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SYNONYMS anti-αL Integrin (human) MAb (MEM-25)
anti-LFA-1 (human) MAb (MEM-25)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products
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ALX-805-061-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-25
ISOTYPE: