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Peptides
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ALX-152-027 Revised 14-Jul-08
BimL (147-164) (human) (cell permeable)
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SYNONYMS BCL2L11 (147-164) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bim / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-027-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-WIAQELRRIGDEFNAYYA-amide
FORMULA: C161H261N61O41
MW: 3707.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Further Categories Containing This Product:
Peptides
 
 
ALX-152-029 Revised 14-Jul-08
Bok (66-83) (human) (cell permeable)
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SYNONYMS NBK (66-83) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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ALX-152-029-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-EVCTVLLRLGDELEQIRP-amide
FORMULA: C149H269N59O41S
MW: 3575.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Further Categories Containing This Product:
Peptides
 
 
ALX-152-018 Revised 20-Aug-02
Bombesin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-152-018-P001   1 mg* 40.00 USD Add To Cart
ALX-152-018-P005   5 mg* 160.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
FORMULA: C71H110N24O18S
MW: 1619.9
CAS NUMBER: 31362-50-2
MERCK INDEX: 14: 1329
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: While lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-152-022 Revised 04-Jul-03
BPDEtide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-022-M001   1 mg 60.00 USD Add To Cart
ALX-152-022-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
FORMULA: C68H115N23O20
MW: 1574.8
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to a peptide sequence surrounding the phosphorylation site of cGMP-binding cGMP-specific phosphodiesterase.
Product Specific Literature References
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase: J.D Corbin & S.O. Døskeland; J. Biol. Chem. 258, 11391 (1983) Abstract; Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases: J.L. Colbran, et al.; J. Biol. Chem. 267, 9589 (1992) Abstract; Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related ProductsPeptides
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
 
 
ALX-153-009 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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SYNONYMS CaM Kinase II (281-289)
CAMK2 (281-289)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-009-M001   1 mg 70.00 USD Add To Cart
ALX-153-009-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-OH
FORMULA: C43H71N15O16S2
MW: 1118.3
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Amino acid sequence defining the major Ca2+-dependent autophosphorylation site of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II: R.J. Colbran, et al.; J. Biol. Chem. 263, 18145 (1988) Abstract; Full Text
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro: M.N. Waxham & J. Aronowski; Biochemistry 32, 2923 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-018 Revised 16-Feb-05
[Ala288]-Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-153-018-M005   5 mg 60.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Ala-Cys-OH
FORMULA: C42H71N15O14S2
MW: 1074.3
PURITY: ≥97%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-010 Revised 16-Feb-05
[Ala286]-Ca2+/Calmodulin-dependent Protein Kinase II (281-302)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-153-010-MC01   0.1 mg 50.00 USD Add To Cart
ALX-153-010-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-OH
FORMULA: C111H191N39O29S2
MW: 2600.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of Ca2+/calmodulin-dependent protein kinase II catalytic fragment, competitive with ATP. The sequence for this product matches that of the original article describing this "CaM kinase II inhibitor" peptide.
Product Specific Literature References
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-006 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (290-309)
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SYNONYMS CaM Kinase II (290-309)
CAMK2 (290-309)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-006-MC01   0.1 mg 40.00 USD Add To Cart
ALX-153-006-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
FORMULA: C103H185N31O24S
MW: 2273.9
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains: M.E. Payne, et al.; J. Biol. Chem. 263, 7190 (1988) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-008 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase IV Substrate
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SYNONYMS CaM Kinase IV Substrate
CAMK4 Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-008-M001   1 mg 70.00 USD Add To Cart
ALX-153-008-M005   5 mg 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Ser-Asp-Gly-Gly-Val-Lys-Lys-Arg-Lys-Ser-Ser-Ser-Ser-OH
FORMULA: C58H107N21O22
MW: 1450.6
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective and potent substrate for a brain-specific Ca2+/calmodulin-dependent protein kinase IV over Ca2+/calmodulin-dependent protein kinase II. This peptide corresponds to aa 345-358 of Ca2+/calmodulin-dependent protein kinase II-δ.
Product Specific Literature References
Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum: O. Miyano, et al.; J. Biol. Chem. 267, 1198 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-021 Revised 26-Aug-02
Calcitonin (human)
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PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Calcitonin & Calcitonin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-021-MC05   0.5 mg 125.00 USD Add To Cart
ALX-153-021-M001   1 mg 220.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2
(Disulfide bond between Cys1-Cys7)
FORMULA: C151H226N40O45S3
MW: 3417.9
CAS NUMBER: 21215-62-3
MERCK INDEX: 14: 1643
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-001 Revised 26-Nov-04
Calcitonin (salmon)
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