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Heparin Binding Factors / Related Products
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ALX-201-173 Revised 18-May-06
Midkine (human) (recombinant) (His)
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SYNONYMS ARAP (human) (recombinant) (His)
Amphiregulin-associated Protein (human) (recombinant) (His)
Neurite Outgrowth-promoting Factor 2 (human) (recombinant) (His)
RIHB (human) (recombinant) (His)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-173-C100   100 µg 532.00 USD Add To Cart
Product Specification
MW: 14.6kDa (for the fusion protein)
SOURCE/HOST: Produced in E. coli. Human midkine is fused at the N-terminus to a His-tag.
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Sterile filtered.
FORMULATION: Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride..
RECONSTITUTION: Reconstitute with 200µl of PBS, pH 7.2.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 2 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Midkine is a retinoic acid inducible heparin binding protein. Promotes neuronal survival and neurite outgrowth and plays a role in carcinogenesis and tissue remodeling. Midkine expression is induced during remodeling after bone fractures.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-174 Revised 18-May-06
Osteoblast Specific Factor 1 (human) (recombinant)
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SYNONYMS OSF-1 (human) (recombinant)
Pleiotrophin (human) (recombinant)
HB-GAM (human) (recombinant)
HARP (human) (recombinant)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-174-C100   100 µg 532.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. Human OSF-1 (osteoblast specific factor 1) is fused at the N-terminus to a thrombin cleveage site and a His-tag.
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Purified by two-step procedure using Ni-NTA and size exclusion chromatography before and after refolding.
FORMULATION: Lyophilized from sterile filtered solution in 0.01M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 200µl PBS, pH 7.2.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 2 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
OSF-1 is an extracellular matrix-associated protein, present in matrices, which act as targets for the deposition of new bone. OSF-1 has the ability to promote adhesion, migration, expansion and differentation of human osteoprogenitor cells.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-175 Revised 29-Jan-08
Osteoblast Specific Factor 2 (human) (recombinant)
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SYNONYMS OSF-2 (human) (recombinant)
Periostin (human) (recombinant)
Fasciclin-I-like (human) (recombinant)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-175-C100   100 µg 532.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. Human OSF-2 (osteoblast specific factor 2) is fused at the N-terminus to a Xa cleavage site and a His-tag.
CONCENTRATION: 0.5mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
PURITY DETAIL: Three-step procedure using affinity Ni-NTA chromotography and size exclusion chromatography before and after refolding.
FORMULATION: Lyophilized from sterile filtered solution in 0.05M acetate buffer, pH 4.0.
RECONSTITUTION: Reconstitute with 200µl of 0.1M acetate buffer, pH 4.0. If a higher pH is required, dilute to a concentration of ~10µg/ml. Solubility is limited in higher concentrations.
APPLICATION: ELISA, Western Blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
OSF-2 functions as a cell adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-210-397 Revised 01-Apr-08
Polyclonal Antibody to Midkine (human)
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SYNONYMS anti-RIHB (human) PAb
anti-Neurite Outgrowth-promoting Factor 2 (human) PAb
anti-Amphiregulin-associated Protein (human) PAb
anti-ARAP (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-397-C050   50 µg 399.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Affinity purified.
FORMULATION: Lyophilized from sterile filtered solution in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human midkine.
SPECIFICITY: Recognizes human midkine.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Midkine is a retinoic acid inducible heparin binding protein. Midkine promotes neuronal survival and neurite outgrowth and plays a role in carcinogenesis and tissue remodeling. Midkine expression is induced during remodeling after bone fractures.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-398 Revised 01-Jun-06
Polyclonal Antibody to Osteoblast Specific Factor 1 (human)
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SYNONYMS anti-OSF-1 (human) PAb
anti-Pleiotrophin (human)  PAb
anti-HB-GAM (human) PAb
anti-HARP (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-398-C050   50 µg 430.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized from sterile filtered solution of affinity purified antibody in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OSF-1 (osteoblast specific factor 1).
SPECIFICITY: Recognizes human OSF-1.
APPLICATION: Immunohistochemistry
ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
OSF-1 is an extracellular matrix-associated protein, present in matrices, which act as targets for the deposition of new bone. OSF-1 has the ability to promote adhesion, migration, expansion and differentation of human osteoprogenitor cells.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-399 Revised 30-Sep-08
Polyclonal Antibody to Osteoblast Specific Factor 2
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SYNONYMS anti-OSF-2 PAb
anti-Periostin PAb
anti-Fasciclin-I-like PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Heparin Binding Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-399-C050   50 µg 430.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Affinity purified.
FORMULATION: Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride. Contains no preservatives.
RECONSTITUTION: Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OSF-2 (osteoblast specific factor 2).
SPECIFICITY: Recognizes human, mouse, rat and chicken OSF-2.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100-1:5'000))
Western Blot (0.1-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre: M.J. Blumer, et al.; J. Anat. 208, 695 (2006) Abstract
A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer: V. Castronovo, et al.; Mol. Cell. Proteomics 5, 2083 (2006) Abstract; Full Text
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data: A. Grigoriadis, et al.; Breast Cancer Res. 8, R56 (2006) Abstract; Full Text
Immunohistochemical localization of alpha-Smooth muscle actin during rat molar tooth development: A. Hosoya, et al.; J. Histochem. Cytochem. 54, 1371 (2006) Abstract
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma: X. Liang, et al.; J. Proteome Res. 5, 2632 (2006) Abstract
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells: P. Li, et al.; J. Appl. Physiol. 102, 390 (2007) Abstract
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity: M. Erkan, et al.; Gastroenterology 132, 1447 (2007) Abstract
General Information
OSF-2 functions as a cell-adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
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