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ALX-804-538
Revised 08-Dec-04
Monoclonal Antibody to Osteocalcin (undercarboxylated) (GluOC4-5)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-538-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Goat
Sheep
Pig
Others
CLONE:
GluOC4-5
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Obtained by fusing the mouse myeloma cells line P3U1 with splenocytes of BALB/c mouse immunized with KLH-conjugated peptide from human osteocalcin. Purified from ascites by ammonium sulfate precipitation and anion exchange chromatography.
FORMULATION:
Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Dissolve in 50µl distilled water to a final concentration of 2mg/ml.
Dilute with 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 14-30 human osteocalcin decarboxylated glutamic acid residues 21 and 24.
SPECIFICITY:
Recognizes human osteocalcin with decarboxylated glutamic acid residues 21 and 24. Cross-reacts with rat, goat, sheep, pig, bovine, rabbit and guinea pig osteocalcin. Does not cross-react with Gla-type osteocalcin.
APPLICATION:
ELISA:
5-10µg/ml. Colorimetric detection; use combination of clones GluOC4-5 (solid phase) and OCG3 (labelled) (Prod. No.
ALX-804-536
).
Immunohistochemistry (paraffin sections):
5-10µg/ml. Fixation by AMeX modified method.
Western Blot:
5-10µg/ml
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted solution can be stored at 4°C for 6 months and at -20°C for 1 year.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-536
Revised 10-Jul-08
Monoclonal Antibody to Osteocalcin (21-31) (OCG3)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-536-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Goat
Sheep
Pig
Others
CLONE:
OCG3
ISOTYPE:
Mouse IgG3
CONCENTRATION:
2mg/ml after reconstitution.
PURITY DETAIL:
Purified by ammonium sulfate precipitation and ion exchange chromatography.
FORMULATION:
Lyophilized from 20mM TBS, pH 7.5, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Reconstitute with 50µl distilled water. Dilute with 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Bovine osteocalcin
SPECIFICITY:
Recognizes aa 21-31 of human, rat, goat, sheep, pig, bovine, and rabbit osteocalcin. Does not cross-react with mouse osteocalcin.
APPLICATION:
Immunohistochemistry (frozen sections; weak on paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at +4°C. Reconstituted antibody is stable for 6 months when stored at +4°C and for 1 year when stored at -20°C. Diluted antibody should not be stored.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Literature References
Characterization of a gamma-carboxyglutamic acid-containing protein from bone
:
P.A. Price, et al.; PNAS
73
, 1447 (1976)
Abstract
Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function
:
P.A. Price; Vitam. Horm.
42
, 65 (1985)
Abstract
A one step sandwich enzyme immunoassay for gamma-carboxylated osteocalcin using monoclonal antibodies
:
N. Koyama, et al.; J. Immunol. Methods
139
, 17 (1991)
Abstract
Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study
:
P. Vergnaud, et al.; J. Clin. Endocrinol. Metab.
82
, 719 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-537
Revised 21-Aug-08
Monoclonal Antibody to Osteocalcin (4-9) (OCG4)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-537-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Goat
Sheep
Dog
Pig
Others
CLONE:
OCG4
ISOTYPE:
Mouse IgG1
CONCENTRATION:
2mg/ml after reconstitution.
PURITY DETAIL:
Purified by ammonium sulfate precipitation and ion exchange chromatography.
FORMULATION:
Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Reconstitute with 50µl distilled water. Dilute with 10mM PBS, pH 7.4, 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Bovine osteocalcin.
SPECIFICITY:
Recognizes aa 4-9 of human, goat, sheep, dog, pig, bovine, rabbit and chicken osteocalcin. Does not cross-react with mouse or rat osteocalcin.
APPLICATION:
Immunohistochemistry (frozen sections, paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted solution is stable for 6 months when stored at +4°C and for 1 year when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Characterization of a gamma-carboxyglutamic acid-containing protein from bone
:
P.A. Price, et al.; PNAS
73
, 1447 (1976)
Abstract
Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function
:
P.A. Price; Vitam. Horm.
42
, 65 (1985)
Abstract
A one step sandwich enzyme immunoassay for gamma-carboxylated osteocalcin using monoclonal antibodies
:
N. Koyama, et al.; J. Immunol. Methods
139
, 17 (1991)
Abstract
Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study
:
P. Vergnaud, et al.; J. Clin. Endocrinol. Metab.
82
, 719 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-535
Revised 02-Mar-07
Monoclonal Antibody to Osteocalcin (45-49) (OCG2)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-535-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
CLONE:
OCG2
ISOTYPE:
Mouse IgG1
CONCENTRATION:
2mg/ml after reconstitution.
FORMULATION:
Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Reconstitute with 50µl distilled water. Dilute with 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Bovine osteocalcin.
SPECIFICITY:
Recognizes aa 45-49 of human and bovine osteocalcin. Does not cross-react with mouse or rat osteocalcin.
APPLICATION:
Immunohistochemistry (frozen sections, paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted solution can be stored at 4°C for 6 months and at -20°C for 1 year.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Literature References
Characterization of a gamma-carboxyglutamic acid-containing protein from bone
:
P.A. Price, et al.; PNAS
73
, 1447 (1976)
Abstract
Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function
:
P.A. Price; Vitam. Horm.
42
, 65 (1985)
Abstract
A one step sandwich enzyme immunoassay for gamma-carboxylated osteocalcin using monoclonal antibodies
:
N. Koyama, et al.; J. Immunol. Methods
139
, 17 (1991)
Abstract
Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study
:
P. Vergnaud, et al.; J. Clin. Endocrinol. Metab.
82
, 719 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-534
Revised 20-Feb-07
Monoclonal Antibody to Osteocalcin (γ-carboxylated) (OC4-30)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-534-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Sheep
Dog
Pig
Others
CLONE:
OC4-30
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
2mg/ml after reconstitution.
PURITY DETAIL:
Ammonium sulfate precipitation and ion exchange chromatography.
FORMULATION:
Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Reconstitute in 50µl distilled water. Dilute in 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Bovine osteocalcin γ-carboxylated at aa 17.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, dog, pig, bovine, goat, rabbit and chicken γ-carboxylated (aa 17) osteocalcin. Does not cross-react with mouse γ-carboxylated (aa 17) osteocalcin or with the decarboxylated variant of the protein.
APPLICATION:
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
After reconstitution, stable for 6 months when stored at 4°C and for 1 year when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Literature References
Characterization of a gamma-carboxyglutamic acid-containing protein from bone
:
P.A. Price, et al.; PNAS
73
, 1447 (1976)
Abstract
Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function
:
P.A. Price; Vitam. Horm.
42
, 65 (1985)
Abstract
A one step sandwich enzyme immunoassay for gamma-carboxylated osteocalcin using monoclonal antibodies
:
N. Koyama, et al.; J. Immunol. Methods
139
, 17 (1991)
Abstract
Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study
:
P. Vergnaud, et al.; J. Clin. Endocrinol. Metab.
82
, 719 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-033
Revised 04-Nov-08
Monoclonal Antibody to PAF Receptor (11A4 (clone 21))
SYNONYMS
anti-Platelet Activating Factor Receptor MAb (11A4 (clone 21))
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-033-C100
100 µg
269.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Pig
Others
CLONE:
11A4 (clone 21)
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 260-269 (L
260
GFQDSKFHQ
269
) of human PAF receptor (platelet activating factor receptor).
SPECIFICITY:
Recognizes human, bovine and pig PAF receptor.
APPLICATION:
Immunocytochemistry (2.5 μg/ml)
For flow cytometry and Western blot, we recommend PAb to PAF Receptor (Prod. No.
ALX-210-715
).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
BLOCKING PEPTIDE:
yes
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-662
Revised 15-Apr-08
Monoclonal Antibody to Progerin (human) (13A4)
SYNONYMS
anti-Δ50 Lamin A (human) MAb (13A4)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Intermediate Filaments Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-662-R200
200 µl
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
13A4
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Purified supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic KLH-coupled peptide corresponding to aa 604-611 (G
604
AQSPQNC
611
) at the C-terminus of human progerin.
SPECIFICITY:
Recognizes human progerin. Does not cross-react with endogenous prelamin A.
APPLICATION:
Immunocytochemistry (1:10)
Immunoprecipitation (20µl/assay)
Western Blot (1:1000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q6UYC3:
human Progerin
Related Products
ALX-804-672
Monoclonal Antibody to Lamin A/C (4C11)
Further Categories Containing This Product:
Monoclonal Antibodies
•
Nuclear Envelope & Nuclear Transport
ALX-804-096
Revised 06-Jan-05
Monoclonal Antibody to β1 Spectrin (4C3)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cytoskeleton & Extracellular Matrix Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-096-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
4C3
ISOTYPE:
Mouse IgG1
FORMULATION:
Contains 0.05% sodium azide.
IMMUNOGEN:
Purified human erythrocyte β1 spectrin (β1 Sp).
SPECIFICITY:
Recognizes alternatively spliced forms of β1 spectrin (β1ε1 and β1ε2) in human, mouse and rat tissues. Does not cross-react with α2 Sp or fodrin.
APPLICATION:
Immunocytochemistry (1:25)
Western Blot (1:100)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-805-085
Revised 12-Jul-07
Monoclonal Antibody to Thy-1 (human) (BC9-G2)
SYNONYMS
anti-CD90 (human) MAb (BC9-G2)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-805-085-L002
2 ml
330.00 USD
Product Specification
CLONE:
BC9-G2
ISOTYPE:
Mouse IgG3.
FORMULATION:
Liquid. Culture supernatant.
IMMUNOGEN:
Human Thy-1 (CD90) transfected CHO cells.
SPECIFICITY:
Recognizes human Thy-1. Detects a band of ~25-35kDa by Western blot.
APPLICATION:
Flow Cytometry
Immunoprecipitation
Western Blot
Functional Application (Blocks Thy-1 mediated cell-cell adhesion)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium:
A. Saalbach, et al.; Oncogene
24
, 4710 (2005)
Abstract
[2]
Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90):
A. Wetzel, et al.; J. Invest. Dermatol.
126
, 441 (2006)
Abstract
[3]
Dermal fibroblasts induce maturation of dendritic cells:
A. Saalbach, et al.; J. Immunol.
178
, 4966 (2007)
Abstract
General Information
Human Thy-1 is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation.
General Literature References
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18):
A. Wetzel, et al.; J. Immunol.
172
, 3850 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Neurobiology & Neurodiseases Other Products
•
Monoclonal Antibodies
•
Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products
ALX-BC-3010-S
Revised 26-Jan-05
Monoclonal Antibody to Titin (F146.9B9)
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cytoskeleton & Extracellular Matrix Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-BC-3010-S-L001
1 ml
135.00 USD
ALX-BC-3010-S-L005
5 ml
460.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
CLONE:
F146.9B9
ISOTYPE:
Mouse IgG1
FORMULATION:
1ml/5ml of sterile filtered supernatant containing 0.1% sodium azide.
IMMUNOGEN:
Purified titin from human skeletal muscle.
SPECIFICITY:
Recognizes human, mouse and rabbit titin.
APPLICATION:
Immunohistochemistry (frozen sections), Western Blot (dilution 1:10).
